Maged Alnawaiseh1, André Rosentreter1,2, Verena Prokosch1, Maria Eveslage3, Nicole Eter1, Lars Zumhagen1,4. 1. a Department of Ophthalmology , University of Muenster Medical Center , Muenster , Germany. 2. b Department of Ophthalmology , University of Würzburg , Würzburg , Germany. 3. c Institute of Biostatistics and Clinical Research, University of Muenster , Muenster , Germany. 4. d Eye Hospital Castrop-Rauxel , Castrop-Rauxel , Germany.
Abstract
PURPOSE: The aim of the study was to quantify corneal densitometry in patients with Fuchs endothelial dystrophy (FED) after endothelial keratoplasty. MATERIALS AND METHODS: We retrospectively reviewed the charts and anterior segment data of patients with FED before and after endothelial keratoplasty. Patients were examined using the Scheimpflug-based Oculus Pentacam corneal densitometry module. Densitometry parameters in different corneal layers and in different annuli were extracted and analyzed. RESULTS: 27 eyes of 27 patients after endothelial keratoplasty (11 DSAEK, 16 DMEK) were included. After endothelial keratoplasty the total corneal light backscatter at total corneal thickness in the central cornea (0-2 mm annulus) was significantly lower than before (DSAEK: p = 0.026, DMEK: p = 0.001). In the entire group the total corneal light backscatter at total corneal thickness and at total diameter before surgery correlated with the postoperative values (Pearson correlation = 0.49, p = 0.01). The strongest correlation was found in the central layer in the DMEK group (Pearson correlation = 0.79, p < 0.001). CONCLUSIONS: Corneal densitometry is a useful, objective method for quantification of the outcome of posterior lamellar keratoplasty irrespective of visual acuity. There is a significant correlation between preoperative and postoperative corneal light backscatter values after endothelial keratoplasty, especially in the case of the DMEK procedure.
PURPOSE: The aim of the study was to quantify corneal densitometry in patients with Fuchs endothelial dystrophy (FED) after endothelial keratoplasty. MATERIALS AND METHODS: We retrospectively reviewed the charts and anterior segment data of patients with FED before and after endothelial keratoplasty. Patients were examined using the Scheimpflug-based Oculus Pentacam corneal densitometry module. Densitometry parameters in different corneal layers and in different annuli were extracted and analyzed. RESULTS: 27 eyes of 27 patients after endothelial keratoplasty (11 DSAEK, 16 DMEK) were included. After endothelial keratoplasty the total corneal light backscatter at total corneal thickness in the central cornea (0-2 mm annulus) was significantly lower than before (DSAEK: p = 0.026, DMEK: p = 0.001). In the entire group the total corneal light backscatter at total corneal thickness and at total diameter before surgery correlated with the postoperative values (Pearson correlation = 0.49, p = 0.01). The strongest correlation was found in the central layer in the DMEK group (Pearson correlation = 0.79, p < 0.001). CONCLUSIONS: Corneal densitometry is a useful, objective method for quantification of the outcome of posterior lamellar keratoplasty irrespective of visual acuity. There is a significant correlation between preoperative and postoperative corneal light backscatter values after endothelial keratoplasty, especially in the case of the DMEK procedure.
Authors: F Poyales; N Garzón; J Mendicute; I Illarramendi; P Caro; O Jáñez; F Argüeso; A López Journal: Eye (Lond) Date: 2017-06-16 Impact factor: 3.775
Authors: Kristin E Hirabayashi; Winston Chamberlain; Jennifer Rose-Nussbaumer; Ariana Austin; Laurel Stell; Charles C Lin Journal: Cornea Date: 2020-06 Impact factor: 2.651