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Literature DB >> 27259145

Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine.

Abstract

Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and regulatory process that plays direct roles in human health and disease. In this Minireview, we discuss how understanding the molecular events that trigger NMD can facilitate strategic targeting of genes via CRISPR/Cas9 technologies and also inform disease diagnostics and treatments.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
RNA, Messenger

Year: 2016 PMID： 27259145 PMCID： PMC4924582 DOI： 10.1016/j.cell.2016.05.053

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

21 in total

Review 1. Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis.

Authors: Lawrence B Gardner
Journal: Mol Cancer Res Date: 2010-02-23 Impact factor: 5.852

Review 2. A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance.

Authors: E Nagy; L E Maquat
Journal: Trends Biochem Sci Date: 1998-06 Impact factor: 13.807

3. Caspases shutdown nonsense-mediated mRNA decay during apoptosis.

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Journal: Cell Death Differ Date: 2015-03-06 Impact factor: 15.828

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Authors: Ophir Shalem; Neville E Sanjana; Feng Zhang
Journal: Nat Rev Genet Date: 2015-04-09 Impact factor: 53.242

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Journal: Hum Mutat Date: 2008-08 Impact factor: 4.878

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Authors: Kalodiah G Toma; Indrani Rebbapragada; Sébastien Durand; Jens Lykke-Andersen
Journal: RNA Date: 2015-03-24 Impact factor: 4.942

7. Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity.

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Journal: Nucleic Acids Res Date: 2015-06-11 Impact factor: 16.971

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Authors: Maximilian W Popp; Lynne E Maquat
Journal: Nat Commun Date: 2015-03-26 Impact factor: 14.919

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Authors: Ya Zhao; Jimin Lin; Beiying Xu; Sida Hu; Xue Zhang; Ligang Wu
Journal: Elife Date: 2014-08-08 Impact factor: 8.140

10. Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway.

Authors: Zhiyun Ge; Bao Lin Quek; Karen L Beemon; J Robert Hogg
Journal: Elife Date: 2016-01-08 Impact factor: 8.140

102 in total

1. hnRNP L-dependent protection of normal mRNAs from NMD subverts quality control in B cell lymphoma.

Authors: Aparna Kishor; Zhiyun Ge; J Robert Hogg
Journal: EMBO J Date: 2018-12-07 Impact factor: 11.598

2. The dual role of the centrosome in organizing the microtubule network in interphase.

Authors: Maria P Gavilan; Pablo Gandolfo; Fernando R Balestra; Francisco Arias; Michel Bornens; Rosa M Rios
Journal: EMBO Rep Date: 2018-09-17 Impact factor: 8.807

3. Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish.

Authors: Kazuyuki Hoshijima; Michael J Jurynec; Dana Klatt Shaw; Ashley M Jacobi; Mark A Behlke; David Jonah Grunwald
Journal: Dev Cell Date: 2019-11-07 Impact factor: 12.270

Review 4. Technical considerations for the use of CRISPR/Cas9 in hematology research.

Authors: Michael C Gundry; Daniel P Dever; David Yudovich; Daniel E Bauer; Simon Haas; Adam C Wilkinson; Sofie Singbrant
Journal: Exp Hematol Date: 2017-07-27 Impact factor: 3.084

Review 5. Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.

Authors: Ali J Marian; Eugene Braunwald
Journal: Circ Res Date: 2017-09-15 Impact factor: 17.367

6. Creation of the 5-hydroxytryptamine receptor 7 knockout rat as a tool for cardiovascular research.

Authors: Elena Y Demireva; Huirong Xie; Emma D Flood; Janice M Thompson; Bridget M Seitz; Stephanie W Watts
Journal: Physiol Genomics Date: 2019-05-24 Impact factor: 3.107

7. CXorf56, a dendritic neuronal protein, identified as a new candidate gene for X-linked intellectual disability.

Authors: Annemieke J M H Verkerk; Shimriet Zeidler; Guido Breedveld; Lydia Overbeek; Daphne Huigh; Linda Koster; Herma van der Linde; Celine de Esch; Lies-Anne Severijnen; Bert B A de Vries; Sigrid M A Swagemakers; Rob Willemsen; A Jeannette M Hoogeboom; Peter J van der Spek; Ben A Oostra
Journal: Eur J Hum Genet Date: 2018-01-26 Impact factor: 4.246

8. In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia.

Authors: Xiaolu Pan; Leonne Philippen; Satadru K Lahiri; Ciaran Lee; So Hyun Park; Tarah A Word; Na Li; Kelsey E Jarrett; Rajat Gupta; Julia O Reynolds; Jean Lin; Gang Bao; William R Lagor; Xander H T Wehrens
Journal: Circ Res Date: 2018-09-28 Impact factor: 17.367

9. Mutations in RARS cause a hypomyelination disorder akin to Pelizaeus-Merzbacher disease.

Authors: Michael Nafisinia; Nara Sobreira; Lisa Riley; Wendy Gold; Birgit Uhlenberg; Claudia Weiß; Corinne Boehm; Kristina Prelog; Robert Ouvrier; John Christodoulou
Journal: Eur J Hum Genet Date: 2017-07-26 Impact factor: 4.246

10. BRCA1 loses the ring but lords over resistance.

Authors: Simon N Powell
Journal: J Clin Invest Date: 2016-07-25 Impact factor: 14.808