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Literature DB >> 27256476

Targeting adipose tissue in the treatment of obesity-associated diabetes.

Christine M Kusminski¹, Perry E Bickel², Philipp E Scherer¹.

Abstract

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. In this Review, we provide an overview of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic strategies targeting adipose tissue, including adipokine-based strategies, promotion of white adipose tissue beiging as well as reduction of inflammation and fibrosis.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2016 PMID： 27256476 DOI： 10.1038/nrd.2016.75

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

300 in total

1. Tracking adipogenesis during white adipose tissue development, expansion and regeneration.

Authors: Qiong A Wang; Caroline Tao; Rana K Gupta; Philipp E Scherer
Journal: Nat Med Date: 2013-09-01 Impact factor: 53.440

2. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans.

Authors: Saverio Cinti; Grant Mitchell; Giorgio Barbatelli; Incoronata Murano; Enzo Ceresi; Emanuela Faloia; Shupei Wang; Melanie Fortier; Andrew S Greenberg; Martin S Obin
Journal: J Lipid Res Date: 2005-09-08 Impact factor: 5.922

3. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

Authors: Yifu Qiu; Khoa D Nguyen; Justin I Odegaard; Xiaojin Cui; Xiaoyu Tian; Richard M Locksley; Richard D Palmiter; Ajay Chawla
Journal: Cell Date: 2014-06-05 Impact factor: 41.582

4. Brown adipose tissue activity controls triglyceride clearance.

Authors: Alexander Bartelt; Oliver T Bruns; Rudolph Reimer; Heinz Hohenberg; Harald Ittrich; Kersten Peldschus; Michael G Kaul; Ulrich I Tromsdorf; Horst Weller; Christian Waurisch; Alexander Eychmüller; Philip L S M Gordts; Franz Rinninger; Karoline Bruegelmann; Barbara Freund; Peter Nielsen; Martin Merkel; Joerg Heeren
Journal: Nat Med Date: 2011-01-23 Impact factor: 53.440

5. Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study.

Authors: Marieke B Snijder; Jacqueline M Dekker; Marjolein Visser; Lex M Bouter; Coen D A Stehouwer; Piet J Kostense; John S Yudkin; Robert J Heine; Giel Nijpels; Jacob C Seidell
Journal: Am J Clin Nutr Date: 2003-05 Impact factor: 7.045

Review 6. Hypoxia and adipocyte physiology: implications for adipose tissue dysfunction in obesity.

Authors: Paul Trayhurn
Journal: Annu Rev Nutr Date: 2014-05-01 Impact factor: 11.848

7. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals.

Authors: David Patsouris; Ping-Ping Li; Divya Thapar; Justin Chapman; Jerrold M Olefsky; Jaap G Neels
Journal: Cell Metab Date: 2008-10 Impact factor: 27.287

8. Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity.

Authors: Eran Elinav; Leonora Niv-Spector; Meirav Katz; Tulin O Price; Mohammed Ali; Michal Yacobovitz; Gili Solomon; Shay Reicher; Jessica L Lynch; Zamir Halpern; William A Banks; Arieh Gertler
Journal: Endocrinology Date: 2009-04-02 Impact factor: 4.736

9. Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.

Authors: John R Ussher; Timothy R Koves; Virgilio J J Cadete; Liyan Zhang; Jagdip S Jaswal; Suzanne J Swyrd; David G Lopaschuk; Spencer D Proctor; Wendy Keung; Deborah M Muoio; Gary D Lopaschuk
Journal: Diabetes Date: 2010-06-03 Impact factor: 9.461

10. A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis.

Authors: Kristin I Stanford; Roeland J W Middelbeek; Kristy L Townsend; Min-Young Lee; Hirokazu Takahashi; Kawai So; Kristen M Hitchcox; Kathleen R Markan; Katharina Hellbach; Michael F Hirshman; Yu-Hua Tseng; Laurie J Goodyear
Journal: Diabetes Date: 2015-01-20 Impact factor: 9.461

204 in total

1. Discovery of Modulators of Adipocyte Physiology Using Fully Functionalized Fragments.

Authors: Andrea Galmozzi; Christopher G Parker; Bernard P Kok; Benjamin F Cravatt; Enrique Saez
Journal: Methods Mol Biol Date: 2018

Review 2. The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.

Authors: Clair Crewe; Yu Aaron An; Philipp E Scherer
Journal: J Clin Invest Date: 2017-01-03 Impact factor: 14.808

Review 3. Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics.

Authors: Alexander Yang; Emilio P Mottillo
Journal: Biochem J Date: 2020-03-13 Impact factor: 3.857

4. [Tribbles pseudokinase 3 inhibits the adipogenic differentiation of human adipose-derived mesenchymal stem cells].

Authors: X S Bai; L W Lv; Y S Zhou
Journal: Beijing Da Xue Xue Bao Yi Xue Ban Date: 2020-02-18

5. Developmental and functional heterogeneity of white adipocytes within a single fat depot.

Authors: Kevin Y Lee; Quyen Luong; Rita Sharma; Jonathan M Dreyfuss; Siegfried Ussar; C Ronald Kahn
Journal: EMBO J Date: 2018-12-10 Impact factor: 11.598

Review 6. The Bioenergetics of Exercise.

Authors: P Darrell Neufer
Journal: Cold Spring Harb Perspect Med Date: 2018-05-01 Impact factor: 6.915

10. Mechanisms of Artemisia scoparia's Anti-Inflammatory Activity in Cultured Adipocytes, Macrophages, and Pancreatic β-Cells.

Authors: Anik Boudreau; Susan J Burke; J Jason Collier; Allison J Richard; David M Ribnicky; Jacqueline M Stephens
Journal: Obesity (Silver Spring) Date: 2020-08-02 Impact factor: 5.002