Lars W Andersen1, Katherine M Berg2, Maureen Chase3, Michael N Cocchi4, Joseph Massaro5, Michael W Donnino6. 1. Department of Medicine, Regional Hospital Holstebro, Aarhus University, Holstebro, Denmark; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark. 2. Department of Medicine, Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. 3. Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. 4. Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Anesthesia Critical Care, Division of Critical Care, Beth Israel Deaconess Medical Center, MA, USA. 5. Harvard Clinical Research Institute, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. 6. Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: mdonnino@bidmc.harvard.edu.
Abstract
AIM: To estimate the United States' incidence and in-hospital mortality of acute respiratory events on inpatient wards and to identify factors associated with mortality. METHODS: This is an analysis of prospectively collected data from the Get With the Guidelines(®) - Resuscitation registry. We included adult patients with index acute respiratory events on inpatient wards from January 2005 to December 2013. A negative binomial regression model was used to estimate the 2012 United States incidence and a multivariable logistic regression model was used to examine time trends and characteristics associated with in-hospital mortality. RESULTS: There were 13,086 index events from 320 hospitals included in the analysis. Using 2012 data, the estimated number of events in the United States was 44,551 (95%CI: 25,170-95,371). The in-hospital mortality for the entire cohort was 39.4% (95%CI: 38.5, 40.2) and rose to 82.6% (95%CI: 79.9, 85.2) for events leading to cardiac arrest. There was a decrease in in-hospital mortality over time (48.3% in 2005 to 34.5% in 2013, p<0.001). Characteristics associated with mortality included agonal breathing, hypotension and septicemia. CONCLUSIONS: Acute respiratory events on inpatient wards in the US is common with an associated in-hospital mortality of approximately 40% that has been decreasing over the past decade. Multiple factors were associated with in-hospital mortality.
AIM: To estimate the United States' incidence and in-hospital mortality of acute respiratory events on inpatient wards and to identify factors associated with mortality. METHODS: This is an analysis of prospectively collected data from the Get With the Guidelines(®) - Resuscitation registry. We included adult patients with index acute respiratory events on inpatient wards from January 2005 to December 2013. A negative binomial regression model was used to estimate the 2012 United States incidence and a multivariable logistic regression model was used to examine time trends and characteristics associated with in-hospital mortality. RESULTS: There were 13,086 index events from 320 hospitals included in the analysis. Using 2012 data, the estimated number of events in the United States was 44,551 (95%CI: 25,170-95,371). The in-hospital mortality for the entire cohort was 39.4% (95%CI: 38.5, 40.2) and rose to 82.6% (95%CI: 79.9, 85.2) for events leading to cardiac arrest. There was a decrease in in-hospital mortality over time (48.3% in 2005 to 34.5% in 2013, p<0.001). Characteristics associated with mortality included agonal breathing, hypotension and septicemia. CONCLUSIONS: Acute respiratory events on inpatient wards in the US is common with an associated in-hospital mortality of approximately 40% that has been decreasing over the past decade. Multiple factors were associated with in-hospital mortality.
Authors: Ari Moskowitz; Lars W Andersen; Mathias Karlsson; Anne V Grossestreuer; Maureen Chase; Michael N Cocchi; Katherine Berg; Michael W Donnino Journal: Resuscitation Date: 2017-03-04 Impact factor: 5.262
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Authors: Carl Mathias Karlsson; Michael W Donnino; Hans Kirkegaard; Michael N Cocchi; Maureen Chase; Lars W Andersen Journal: J Emerg Med Date: 2017-01-17 Impact factor: 1.484
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Authors: Ashish K Khanna; Sergio D Bergese; Carla R Jungquist; Hiroshi Morimatsu; Shoichi Uezono; Simon Lee; Lian Kah Ti; Richard D Urman; Robert McIntyre; Carlos Tornero; Albert Dahan; Leif Saager; Toby N Weingarten; Maria Wittmann; Dennis Auckley; Luca Brazzi; Morgan Le Guen; Roy Soto; Frank Schramm; Sabry Ayad; Roop Kaw; Paola Di Stefano; Daniel I Sessler; Alberto Uribe; Vanessa Moll; Susan J Dempsey; Wolfgang Buhre; Frank J Overdyk Journal: Anesth Analg Date: 2020-10 Impact factor: 6.627