Literature DB >> 27247245

Phenotypic Screens in Antimalarial Drug Discovery.

Marisa L Hovlid1, Elizabeth A Winzeler2.   

Abstract

Phenotypic high-throughput screens are a valuable tool for identifying new chemical compounds with antimalarial activity. Traditionally, these screens have focused solely on the symptomatic asexual blood stage of the parasite life cycle; however, to discover new medicines for malaria treatment and prevention, robust screening technologies against other parasite life-cycle stages are required. This review highlights recent advances and progress toward phenotypic screening methodologies over the past several years, with a focus on exoerythrocytic stage screens.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  drug discovery; high-throughput screening; malaria; phenotypic screens

Mesh：

Substances：

Year:  2016        PMID： 27247245      PMCID： PMC5007148          DOI： 10.1016/j.pt.2016.04.014

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  69 in total

Review 1.  Cell-based screening using high-throughput flow cytometry.

Authors:  Christopher B Black; Thomas D Duensing; Linda S Trinkle; R Terry Dunlay
Journal:  Assay Drug Dev Technol       Date:  2010-11-04       Impact factor: 1.738

2.  Evaluation of the standard membrane feeding assay (SMFA) for the determination of malaria transmission-reducing activity using empirical data.

Authors:  M van der Kolk; S J De Vlas; A Saul; M van de Vegte-Bolmer; W M Eling; R W Sauerwein; W Sauerwein
Journal:  Parasitology       Date:  2005-01       Impact factor: 3.234

3.  Thousands of chemical starting points for antimalarial lead identification.

Authors:  Francisco-Javier Gamo; Laura M Sanz; Jaume Vidal; Cristina de Cozar; Emilio Alvarez; Jose-Luis Lavandera; Dana E Vanderwall; Darren V S Green; Vinod Kumar; Samiul Hasan; James R Brown; Catherine E Peishoff; Lon R Cardon; Jose F Garcia-Bustos
Journal:  Nature       Date:  2010-05-20       Impact factor: 49.962

4.  New approach for high-throughput screening of drug activity on Plasmodium liver stages.

Authors:  Audrey Gego; Olivier Silvie; Jean-François Franetich; Khemaïs Farhati; Laurent Hannoun; Adrian J F Luty; Robert W Sauerwein; Claude Boucheix; Eric Rubinstein; Dominique Mazier
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

5.  Regional differences in the response of Plasmodium vivax malaria to primaquine as anti-relapse therapy.

Authors:  Jane L Goller; Damien Jolley; Pascal Ringwald; Beverley-Ann Biggs
Journal:  Am J Trop Med Hyg       Date:  2007-02       Impact factor: 2.345

Review 6.  The economic and social burden of malaria.

Authors:  Jeffrey Sachs; Pia Malaney
Journal:  Nature       Date:  2002-02-07       Impact factor: 49.962

7.  Chemical genetics of Plasmodium falciparum.

Authors:  W Armand Guiguemde; Anang A Shelat; David Bouck; Sandra Duffy; Gregory J Crowther; Paul H Davis; David C Smithson; Michele Connelly; Julie Clark; Fangyi Zhu; María B Jiménez-Díaz; María S Martinez; Emily B Wilson; Abhai K Tripathi; Jiri Gut; Elizabeth R Sharlow; Ian Bathurst; Farah El Mazouni; Joseph W Fowble; Isaac Forquer; Paula L McGinley; Steve Castro; Iñigo Angulo-Barturen; Santiago Ferrer; Philip J Rosenthal; Joseph L Derisi; David J Sullivan; John S Lazo; David S Roos; Michael K Riscoe; Margaret A Phillips; Pradipsinh K Rathod; Wesley C Van Voorhis; Vicky M Avery; R Kiplin Guy
Journal:  Nature       Date:  2010-05-20       Impact factor: 49.962

8.  In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

Authors:  David Plouffe; Achim Brinker; Case McNamara; Kerstin Henson; Nobutaka Kato; Kelli Kuhen; Advait Nagle; Francisco Adrián; Jason T Matzen; Paul Anderson; Tae-Gyu Nam; Nathanael S Gray; Arnab Chatterjee; Jeff Janes; S Frank Yan; Richard Trager; Jeremy S Caldwell; Peter G Schultz; Yingyao Zhou; Elizabeth A Winzeler
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-25       Impact factor: 11.205

Review 9.  Cultivation of plasmodium spp.

Authors:  Frederick L Schuster
Journal:  Clin Microbiol Rev       Date:  2002-07       Impact factor: 26.132

Review 10.  A research agenda to underpin malaria eradication.

Authors:  Pedro L Alonso; Graham Brown; Myriam Arevalo-Herrera; Fred Binka; Chetan Chitnis; Frank Collins; Ogobara K Doumbo; Brian Greenwood; B Fenton Hall; Myron M Levine; Kamini Mendis; Robert D Newman; Christopher V Plowe; Mario Henry Rodríguez; Robert Sinden; Laurence Slutsker; Marcel Tanner
Journal:  PLoS Med       Date:  2011-01-25       Impact factor: 11.069
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  14 in total

1.  Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum.

Authors:  Aloysus Lawong; Suraksha Gahalawat; John Okombo; Josefine Striepen; Tomas Yeo; Sachel Mok; Ioanna Deni; Jessica L Bridgford; Hanspeter Niederstrasser; Anwu Zhou; Bruce Posner; Sergio Wittlin; Francisco Javier Gamo; Benigno Crespo; Alisje Churchyard; Jake Baum; Nimisha Mittal; Elizabeth Winzeler; Benoît Laleu; Michael J Palmer; Susan A Charman; David A Fidock; Joseph M Ready; Margaret A Phillips
Journal:  J Med Chem       Date:  2021-02-23       Impact factor: 7.446

Review 2.  High-content approaches to anthelmintic drug screening.

Authors:  Mostafa Zamanian; John D Chan
Journal:  Trends Parasitol       Date:  2021-06-03

Review 3.  Chemoproteomics for Plasmodium Parasite Drug Target Discovery.

Authors:  Kuan-Yi Lu; Christopher R Mansfield; Michael C Fitzgerald; Emily R Derbyshire
Journal:  Chembiochem       Date:  2021-06-10       Impact factor: 3.461

Review 4.  New developments in anti-malarial target candidate and product profiles.

Authors:  Jeremy N Burrows; Stephan Duparc; Winston E Gutteridge; Rob Hooft van Huijsduijnen; Wiweka Kaszubska; Fiona Macintyre; Sébastien Mazzuri; Jörg J Möhrle; Timothy N C Wells
Journal:  Malar J       Date:  2017-01-13       Impact factor: 2.979

5.  Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.

Authors:  Gregory M LaMonte; Jehad Almaliti; Betsaida Bibo-Verdugo; Lena Keller; Bing Yu Zou; Jennifer Yang; Yevgeniya Antonova-Koch; Pamela Orjuela-Sanchez; Colleen A Boyle; Edgar Vigil; Lawrence Wang; Gregory M Goldgof; Lena Gerwick; Anthony J O'Donoghue; Elizabeth A Winzeler; William H Gerwick; Sabine Ottilie
Journal:  J Med Chem       Date:  2017-07-25       Impact factor: 7.446

Review 6.  Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation.

Authors:  Edgar Deu
Journal:  FEBS J       Date:  2017-07-03       Impact factor: 5.542

7.  The need to compare: assessing the level of agreement of three high-throughput assays against Plasmodium falciparum mature gametocytes.

Authors:  Leonardo Lucantoni; Sasdekumar Loganathan; Vicky M Avery
Journal:  Sci Rep       Date:  2017-04-05       Impact factor: 4.379

8.  Screening for potential prophylactics targeting sporozoite motility through the skin.

Authors:  Ross G Douglas; Miriam Reinig; Matthew Neale; Friedrich Frischknecht
Journal:  Malar J       Date:  2018-08-31       Impact factor: 2.979

Review 9.  malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication.

Authors: 
Journal:  PLoS Med       Date:  2017-11-30       Impact factor: 11.069

Review 10.  Challenges and recent progress in drug discovery for tropical diseases.

Authors:  Manu De Rycker; Beatriz Baragaña; Suzanne L Duce; Ian H Gilbert
Journal:  Nature       Date:  2018-07-25       Impact factor: 49.962
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