Niels Herluf Paulsen1, Bjarke Bønløkke Carlsen1, Jordi Sanchez Dahl1, Rasmus Carter-Storch1, Nicolaj Lyhne Christensen1, Lida Khurrami1, Jacob Eifer Møller2, Jes Sandal Lindholt3, Axel Cosmus Pyndt Diederichsen4. 1. Department of Cardiology, Odense University Hospital, Denmark. 2. Department of Cardiology, Odense University Hospital, Denmark; Cardiovascular Centre of Excellence (CAVAC), Denmark. 3. Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Denmark; Cardiovascular Centre of Excellence (CAVAC), Denmark; Elitary Research Centre of Individualised Medicine in Arterial Disease (CIMA), Denmark. 4. Department of Cardiology, Odense University Hospital, Denmark; Cardiovascular Centre of Excellence (CAVAC), Denmark; Elitary Research Centre of Individualised Medicine in Arterial Disease (CIMA), Denmark. Electronic address: axel.diederichsen@rsyd.dk.
Abstract
BACKGROUND: Aortic valve calcification (AVC) measured on non-contrast computed tomography (CT) has shown correlation to severity of aortic valve stenosis (AS) and mortality in patients with known AS. The aim of this study was to determine the association of CT verified AVC and subclinical AS in a general population undergoing CT. METHODS: CT scans from 566 randomly selected male participants (age 65-74) in the Danish cardiovascular screening study (DANCAVAS) were analyzed for AVC. All participants with a moderately or severely increased AVC score (≥300 arbitrary units (AU)) and a matched control group were invited for a supplementary echocardiography. AS was graded by indexed aortic valve area (AVAi) on echocardiography as moderate 0.6-0.85 cm(2)/m(2) and severe < 0.6 cm(2)/m(2), respectively. ROC- and regression analyses were performed. RESULTS: Due to prior valve surgery, and artifacts from ICD leads 16 individuals were excluded from the AVC scoring. Moderate or severe increased AVC was observed in 10.7% (95% CI: 8.4-13.7). Echocardiography was performed in 101 individuals; 32.7% (95% CI: 21.8 to 46.0) with moderate or high AVC score had moderate or severe AS, while none with no or low AVC. A ROC analysis defined an AVC score ≥588 AU to be suggestive of moderate or severe AS (AUC 0.89 ± 0.04, sensitivity 83% and specificity 87%). In the univariate analyses, AVC was the only variable significantly associated with AS. CONCLUSIONS: This study indicates an association between CT verified AVC and subclinical AS.
BACKGROUND:Aortic valve calcification (AVC) measured on non-contrast computed tomography (CT) has shown correlation to severity of aortic valve stenosis (AS) and mortality in patients with known AS. The aim of this study was to determine the association of CT verified AVC and subclinical AS in a general population undergoing CT. METHODS: CT scans from 566 randomly selected male participants (age 65-74) in the Danish cardiovascular screening study (DANCAVAS) were analyzed for AVC. All participants with a moderately or severely increased AVC score (≥300 arbitrary units (AU)) and a matched control group were invited for a supplementary echocardiography. AS was graded by indexed aortic valve area (AVAi) on echocardiography as moderate 0.6-0.85 cm(2)/m(2) and severe < 0.6 cm(2)/m(2), respectively. ROC- and regression analyses were performed. RESULTS: Due to prior valve surgery, and artifacts from ICD leads 16 individuals were excluded from the AVC scoring. Moderate or severe increased AVC was observed in 10.7% (95% CI: 8.4-13.7). Echocardiography was performed in 101 individuals; 32.7% (95% CI: 21.8 to 46.0) with moderate or high AVC score had moderate or severe AS, while none with no or low AVC. A ROC analysis defined an AVC score ≥588 AU to be suggestive of moderate or severe AS (AUC 0.89 ± 0.04, sensitivity 83% and specificity 87%). In the univariate analyses, AVC was the only variable significantly associated with AS. CONCLUSIONS: This study indicates an association between CT verified AVC and subclinical AS.
Authors: Kojo Amoakwa; Oluwaseun E Fashanu; Martin Tibuakuu; Di Zhao; Eliseo Guallar; Seamus P Whelton; Wesley T O'Neal; Wendy S Post; Matthew J Budoff; Erin D Michos Journal: Atherosclerosis Date: 2018-04-06 Impact factor: 5.162