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Literature DB >> 2724415

Genetic and biochemical characterization of the thymidine kinase gene from herpesvirus of turkeys.

S L Martin¹, D I Aparisio, P K Bandyopadhyay.

Abstract

The thymidine kinase gene encoded by herpesvirus of turkeys has been identified and characterized. A viral mutant (ATR0) resistant to 1-beta-D-arabinofuranosylthymine was isolated. This mutant was also resistant to 1-(2-fluoro-2-deoxy-beta-D-arabinofuronosyl)-5-methyluracil and was unable to incorporate [125I]deoxycytidine into DNA. The mutant phenotype was rescued by a cloned region of the turkey herpesvirus genome whose DNA sequence was found to contain an open reading frame similar to that for known thymidine kinases from other viruses. When expressed in Escherichia coli, this open reading frame complemented a thymidine kinase-deficient strain and resulted in thymidine kinase activity in extracts assayed in vitro.

Entities: Chemical Species

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Year: 1989 PMID： 2724415 PMCID： PMC250796

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

33 in total

1. Possible peptide chain termination mutants in thymide kinase gene of a mammalian virus, herpes simplex virus.

Authors: W P Summers; M Wagner; W C Summers
Journal: Proc Natl Acad Sci U S A Date: 1975-10 Impact factor: 11.205

2. A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.

Authors: J G Jacobson; S L Martin; D M Coen
Journal: J Virol Date: 1989-04 Impact factor: 5.103

2. Construction of a pigeonpox virus recombinant: expression of the Newcastle disease virus (NDV) fusion glycoprotein and protection of chickens against NDV challenge.

Authors: C Letellier; A Burny; G Meulemans
Journal: Arch Virol Date: 1991 Impact factor: 2.574

3. Cosmid cloning and restriction endonuclease mapping of the herpesvirus of turkeys (HVT) genome.

Authors: W Lindenmaier; H J Bauer
Journal: Arch Virol Date: 1994 Impact factor: 2.574

4. Role of the TK+ phenotype in the stability of pigeonpox virus recombinant.

Authors: C Letellier
Journal: Arch Virol Date: 1993 Impact factor: 2.574

4 in total

Genetic and biochemical characterization of the thymidine kinase gene from herpesvirus of turkeys.

1. Possible peptide chain termination mutants in thymide kinase gene of a mammalian virus, herpes simplex virus.

2. A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.

3. Phosphorylation of 5-bromodeoxycytidine in cells infected with herpes simplex virus.

4. Induction of both thymidine and deoxycytidine kinase activity by herpes viruses.

5. Responses of cell cultures from various avian species to Marek's disease virus and herpesvirus of turkeys.

6. A deoxythymidine kinase deficient mutant of Escherichia coli. II. Mapping and transduction studies with phage phi 80.

7. A new technique for the assay of infectivity of human adenovirus 5 DNA.

8. In vitro methods for assay of turkey herpesvirus.

9. Susceptibility of mammalian and avian cell cultures to infection with cell-free turkey herpes virus.

10. [125I]deoxycytidine used in a rapid, sensitive, and specific assay for herpes simplex virus type 1 thymidine kinase.

1. The genome of turkey herpesvirus.

2. Construction of a pigeonpox virus recombinant: expression of the Newcastle disease virus (NDV) fusion glycoprotein and protection of chickens against NDV challenge.

3. Cosmid cloning and restriction endonuclease mapping of the herpesvirus of turkeys (HVT) genome.

4. Role of the TK+ phenotype in the stability of pigeonpox virus recombinant.