Literature DB >> 27239942

The oxadiazole antibacterials.

Jeshina Janardhanan1, Mayland Chang2, Shahriar Mobashery3.   

Abstract

The oxadiazoles are a class of antibacterials discovered by in silico docking and scoring of compounds against the X-ray structure of a penicillin-binding protein. These antibacterials exhibit activity against Gram-positive bacteria, including against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). They show in vivo efficacy in murine models of peritonitis/sepsis and neutropenic thigh MRSA infection. They are bactericidal and orally bioavailable. The oxadiazoles show promise in treatment of MRSA infection.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27239942      PMCID： PMC5069118          DOI： 10.1016/j.mib.2016.05.009

Source DB:  PubMed          Journal:  Curr Opin Microbiol        ISSN： 1369-5274            Impact factor:   7.934


  26 in total

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Review 5.  Penicillin-binding proteins and bacterial resistance to beta-lactams.

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6.  Mutations in mmpL and in the cell wall stress stimulon contribute to resistance to oxadiazole antibiotics in methicillin-resistant Staphylococcus aureus.

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Review 4.  Ligands and Receptors with Broad Binding Capabilities Have Common Structural Characteristics: An Antibiotic Design Perspective.

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5.  Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract.

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  5 in total

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