Literature DB >> 27238638

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans.

Maria Chondronikola1, Elena Volpi2, Elisabet Børsheim3, Craig Porter3, Manish K Saraf3, Palam Annamalai4, Christina Yfanti5, Tony Chao6, Daniel Wong7, Kosaku Shinoda7, Sebastien M Labbė8, Nicholas M Hurren3, Fernardo Cesani9, Shingo Kajimura7, Labros S Sidossis10.   

Abstract

Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. We studied 16 overweight/obese men during prolonged, non-shivering cold and thermoneutral conditions using stable isotopic tracer methodologies in conjunction with hyperinsulinemic-euglycemic clamps and BAT and white adipose tissue (WAT) biopsies. BAT volume was significantly associated with increased whole-body lipolysis, triglyceride-free fatty acid (FFA) cycling, FFA oxidation, and adipose tissue insulin sensitivity. Functional analysis of BAT and WAT demonstrated the greater thermogenic capacity of BAT compared to WAT, while molecular analysis revealed a cold-induced upregulation of genes involved in lipid metabolism only in BAT. The accelerated mobilization and oxidation of lipids upon BAT activation supports a putative role for BAT in the regulation of lipid metabolism in humans.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27238638      PMCID： PMC4967557          DOI： 10.1016/j.cmet.2016.04.029

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  30 in total

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2.  Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans.

Authors:  Véronique Ouellet; Sébastien M Labbé; Denis P Blondin; Serge Phoenix; Brigitte Guérin; François Haman; Eric E Turcotte; Denis Richard; André C Carpentier
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3.  Brown adipose tissue activity controls triglyceride clearance.

Authors:  Alexander Bartelt; Oliver T Bruns; Rudolph Reimer; Heinz Hohenberg; Harald Ittrich; Kersten Peldschus; Michael G Kaul; Ulrich I Tromsdorf; Horst Weller; Christian Waurisch; Alexander Eychmüller; Philip L S M Gordts; Franz Rinninger; Karoline Bruegelmann; Barbara Freund; Peter Nielsen; Martin Merkel; Joerg Heeren
Journal:  Nat Med       Date:  2011-01-23       Impact factor: 53.440

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Authors:  C R Kahn
Journal:  Metabolism       Date:  1978-12       Impact factor: 8.694

5.  High-intensity interval aerobic training reduces hepatic very low-density lipoprotein-triglyceride secretion rate in men.

Authors:  Yiannis E Tsekouras; Faidon Magkos; Yiannis Kellas; Konstantinos N Basioukas; Stavros A Kavouras; Labros S Sidossis
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6.  Cold-activated brown adipose tissue in healthy men.

Authors:  Wouter D van Marken Lichtenbelt; Joost W Vanhommerig; Nanda M Smulders; Jamie M A F L Drossaerts; Gerrit J Kemerink; Nicole D Bouvy; Patrick Schrauwen; G J Jaap Teule
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8.  Multiorgan insulin sensitivity in lean and obese subjects.

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10.  High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity.

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Journal:  Diabetes       Date:  2009-04-28       Impact factor: 9.461
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2.  Developmental and functional heterogeneity of white adipocytes within a single fat depot.

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Review 3.  The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment.

Authors:  Chelsea Hepler; Rana K Gupta
Journal:  Mol Cell Endocrinol       Date:  2016-10-12       Impact factor: 4.102

Review 4.  Brown adipocyte glucose metabolism: a heated subject.

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5.  Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice.

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6.  Sepsis Increases Muscle Proteolysis in Severely Burned Adults, but Does not Impact Whole-Body Lipid or Carbohydrate Kinetics.

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Review 9.  Epigenetic Regulation of the Thermogenic Adipose Program.

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Review 10.  Non-invasive methods for the assessment of brown adipose tissue in humans.

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