Christopher Gundlach1, Matthias M Müller2, Till Nierhaus3, Arno Villringer4, Bernhard Sehm5. 1. Department for Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Institute of Psychology, University of Leipzig, 04109 Leipzig, Germany. Electronic address: christopher.gundlach@uni-leipzig.de. 2. Institute of Psychology, University of Leipzig, 04109 Leipzig, Germany. 3. Department for Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Center for Cognitive Neuroscience Berlin, Freie Universität, 14195 Berlin, Germany. 4. Department for Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Mind-Brain Institute and Berlin School of Mind and Brain, Charité Universitätsmedizin Berlin and Humboldt-University, 10099 Berlin, Germany; Berlin Neuroimaging Center and Department of Neurology, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany; Clinic for Cognitive Neurology, University of Leipzig, 04103 Leipzig, Germany. 5. Department for Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Clinic for Cognitive Neurology, University of Leipzig, 04103 Leipzig, Germany.
Abstract
BACKGROUND: Why are weak sensory stimuli sometimes perceived and other times not? Experimental paradigms using near-threshold stimuli suggest that spontaneous brain network dynamics are involved in separating relevant from irrelevant information. Recent findings in human visual perception provide evidence that the immediate spontaneous brain state, i.e. the phase of alpha oscillations, predicts whether a coinciding stimulus is further processed or not. OBJECTIVES: Here, we investigated whether this concept of a "pulsed inhibition" involved in sensory gating represents a general mechanism of conscious human perception and can be modulated with non-invasive brain stimulation. METHODS: Hence, we used transcranial alternating current stimulation (tACS) at the individualized mu-alpha frequency to entrain somatosensory mu-alpha oscillations, and investigated the effect on somatosensory detection in healthy humans. tACS (or sham, respectively) was applied over primary somatosensory cortices (mu-tACS) while participants performed a detection task of somatosensory near-threshold stimuli. RESULTS: We found that mean perception thresholds during mu-tACS did not change as compared to sham stimulation. However, during mu-tACS, somatosensory detection thresholds varied as a function of the applied tACS phase. This effect was not found when tACS was applied over occipital areas at participant's individual visual alpha frequency. CONCLUSION: Our data indicate that tACS applied at an endogenous frequency is capable of modulating human somatosensory perception by inducing phase-dependent periods of excitation and inhibition, i.e. entraining ongoing mu-alpha oscillations. These findings support the idea that the "pulsed inhibition" framework for sensory gating applies to somatosensory mu-alpha oscillations and might therefore represent a general, but sensory-specific mechanism of conscious human perception.
BACKGROUND: Why are weak sensory stimuli sometimes perceived and other times not? Experimental paradigms using near-threshold stimuli suggest that spontaneous brain network dynamics are involved in separating relevant from irrelevant information. Recent findings in human visual perception provide evidence that the immediate spontaneous brain state, i.e. the phase of alpha oscillations, predicts whether a coinciding stimulus is further processed or not. OBJECTIVES: Here, we investigated whether this concept of a "pulsed inhibition" involved in sensory gating represents a general mechanism of conscious human perception and can be modulated with non-invasive brain stimulation. METHODS: Hence, we used transcranial alternating current stimulation (tACS) at the individualized mu-alpha frequency to entrain somatosensory mu-alpha oscillations, and investigated the effect on somatosensory detection in healthy humans. tACS (or sham, respectively) was applied over primary somatosensory cortices (mu-tACS) while participants performed a detection task of somatosensory near-threshold stimuli. RESULTS: We found that mean perception thresholds during mu-tACS did not change as compared to sham stimulation. However, during mu-tACS, somatosensory detection thresholds varied as a function of the applied tACS phase. This effect was not found when tACS was applied over occipital areas at participant's individual visual alpha frequency. CONCLUSION: Our data indicate that tACS applied at an endogenous frequency is capable of modulating human somatosensory perception by inducing phase-dependent periods of excitation and inhibition, i.e. entraining ongoing mu-alpha oscillations. These findings support the idea that the "pulsed inhibition" framework for sensory gating applies to somatosensory mu-alpha oscillations and might therefore represent a general, but sensory-specific mechanism of conscious human perception.
Authors: Danielle D Sliva; Christopher J Black; Paul Bowary; Uday Agrawal; Juan F Santoyo; Noah S Philip; Benjamin D Greenberg; Christopher I Moore; Stephanie R Jones Journal: Front Psychol Date: 2018-11-20
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Authors: Christopher Gundlach; Matthias M Müller; Till Nierhaus; Arno Villringer; Bernhard Sehm Journal: Front Hum Neurosci Date: 2017-08-25 Impact factor: 3.169