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Literature DB >> 27235676

Why Argonaute is needed to make microRNA target search fast and reliable.

Misha Klein¹, Stanley D Chandradoss¹, Martin Depken², Chirlmin Joo³.

Abstract

MicroRNA (miRNA) interferes with the translation of cognate messenger RNA (mRNA) by finding, preferentially binding, and marking it for degradation. To facilitate the search process, Argonaute (Ago) proteins come together with miRNA, forming a dynamic search complex. In this review we use the language of free-energy landscapes to discuss recent single-molecule and high-resolution structural data in the light of theoretical work appropriated from the study of transcription-factor search. We suggest that experimentally observed internal states of the Ago-miRNA search complex may have the explicit biological function of speeding up search while maintaining specificity.

Keywords: Argonaute; FRET; Free-energy landscape; Lateral diffusion; MicroRNA target prediction; RNA silencing; Search stability paradox; Single molecule; Target Search; Theoretical model; miRNA

Mesh：

Substances：

Year: 2016 PMID： 27235676 DOI： 10.1016/j.semcdb.2016.05.017

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

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Cited

17 in total

Why Argonaute is needed to make microRNA target search fast and reliable.

1. Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing.

Review 2. Facilitated diffusion of Argonaute-mediated target search.

Review 3. Structural Foundations of RNA Silencing by Argonaute.

4. DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute.

5. piRNAs of Caenorhabditis elegans broadly silence nonself sequences through functionally random targeting.

6. Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition.

7. TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments.

Review 8. The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease.

9. A systematic approach to RNA-associated motif discovery.

10. Expression Status of PIWIL1 as a Prognostic Marker of Colorectal Cancer.