Literature DB >> 27230528

PGC1α drives a metabolic block on prostate cancer progression.

Martina Wallace1, Christian M Metallo1,2.   

Abstract

Metabolic rewiring is essential for cancer cell survival. PGC1α, a transcriptional co-activator that is downregulated in prostate cancer, is now shown to control prostate cancer metabolism by activating an oxidative metabolic program that prevents tumour growth and metastatic dissemination.

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Year:  2016        PMID： 27230528     DOI： 10.1038/ncb3365

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

Review 1.  Metabolic control through the PGC-1 family of transcription coactivators.

Authors:  Jiandie Lin; Christoph Handschin; Bruce M Spiegelman
Journal:  Cell Metab       Date:  2005-06       Impact factor: 27.287

2.  PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.

Authors:  Francisca Vazquez; Ji-Hong Lim; Helen Chim; Kavita Bhalla; Geoff Girnun; Kerry Pierce; Clary B Clish; Scott R Granter; Hans R Widlund; Bruce M Spiegelman; Pere Puigserver
Journal:  Cancer Cell       Date:  2013-02-14       Impact factor: 31.743

3.  Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma.

Authors:  Edward L LaGory; Colleen Wu; Cullen M Taniguchi; Chien-Kuang Cornelia Ding; Jen-Tsan Chi; Rie von Eyben; David A Scott; Adam D Richardson; Amato J Giaccia
Journal:  Cell Rep       Date:  2015-06-25       Impact factor: 9.423

4.  Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes.

Authors:  C J Lynch; H L Fox; T C Vary; L S Jefferson; S R Kimball
Journal:  J Cell Biochem       Date:  2000-03       Impact factor: 4.429

5.  Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment.

Authors:  Zachary T Schafer; Alexandra R Grassian; Loling Song; Zhenyang Jiang; Zachary Gerhart-Hines; Hanna Y Irie; Sizhen Gao; Pere Puigserver; Joan S Brugge
Journal:  Nature       Date:  2009-08-19       Impact factor: 49.962

6.  MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.

Authors:  Patricia Sancho; Emma Burgos-Ramos; Alejandra Tavera; Tony Bou Kheir; Petra Jagust; Matthieu Schoenhals; David Barneda; Katherine Sellers; Ramon Campos-Olivas; Osvaldo Graña; Catarina R Viera; Mariia Yuneva; Bruno Sainz; Christopher Heeschen
Journal:  Cell Metab       Date:  2015-09-10       Impact factor: 27.287

7.  Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues.

Authors:  Keshav K Singh; Mohamed M Desouki; Renty B Franklin; Leslie C Costello
Journal:  Mol Cancer       Date:  2006-04-04       Impact factor: 27.401

8.  PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.

Authors:  Valerie S LeBleu; Joyce T O'Connell; Karina N Gonzalez Herrera; Harriet Wikman; Klaus Pantel; Marcia C Haigis; Fernanda Machado de Carvalho; Aline Damascena; Ludmilla Thome Domingos Chinen; Rafael M Rocha; John M Asara; Raghu Kalluri
Journal:  Nat Cell Biol       Date:  2014-09-21       Impact factor: 28.824

9.  Reductive carboxylation supports redox homeostasis during anchorage-independent growth.

Authors:  Lei Jiang; Alexander A Shestov; Pamela Swain; Chendong Yang; Seth J Parker; Qiong A Wang; Lance S Terada; Nicholas D Adams; Michael T McCabe; Beth Pietrak; Stan Schmidt; Christian M Metallo; Brian P Dranka; Benjamin Schwartz; Ralph J DeBerardinis
Journal:  Nature       Date:  2016-04-06       Impact factor: 49.962

10.  Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis.

Authors:  Courtney R Green; Martina Wallace; Ajit S Divakaruni; Susan A Phillips; Anne N Murphy; Theodore P Ciaraldi; Christian M Metallo
Journal:  Nat Chem Biol       Date:  2015-11-16       Impact factor: 15.040
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  5 in total

1.  CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition.

Authors:  Adele M Musicant; Kshitij Parag-Sharma; Weida Gong; Monideepa Sengupta; Arindam Chatterjee; Erin C Henry; Yi-Hsuan Tsai; Michele C Hayward; Siddharth Sheth; Renee Betancourt; Trevor G Hackman; Ricardo J Padilla; Joel S Parker; Jimena Giudice; Colin A Flaveny; David N Hayes; Antonio L Amelio
Journal:  Cell Rep       Date:  2021-02-23       Impact factor: 9.423

Review 2.  ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway.

Authors:  Yang Zhao; Xingbin Hu; Yajing Liu; Shumin Dong; Zhaowei Wen; Wanming He; Shuyi Zhang; Qiong Huang; Min Shi
Journal:  Mol Cancer       Date:  2017-04-13       Impact factor: 27.401

3.  Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function.

Authors:  Humberto De Vitto; Joohyun Ryu; Ali Calderon-Aparicio; Josh Monts; Raja Dey; Abhijit Chakraborty; Mee-Hyun Lee; Ann M Bode; Zigang Dong
Journal:  Cancer Metab       Date:  2020-12-10

4.  Predicting biochemical-recurrence-free survival using a three-metabolic-gene risk score model in prostate cancer patients.

Authors:  Yiqiao Zhao; Zijia Tao; Lei Li; Jianyi Zheng; Xiaonan Chen
Journal:  BMC Cancer       Date:  2022-03-04       Impact factor: 4.430

5.  Lipid reprogramming induced by the TFEB-ERRα axis enhanced membrane fluidity to promote EC progression.

Authors:  Xiaodan Mao; Huifang Lei; Tianjin Yi; Pingping Su; Shuting Tang; Yao Tong; Binhua Dong; Guanyu Ruan; Alexander Mustea; Jalid Sehouli; Pengming Sun
Journal:  J Exp Clin Cancer Res       Date:  2022-01-19
  5 in total

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