Literature DB >> 27223254

Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro.

Andrew I Share1, Khushali Patel, Cristina Nativi, Eun J Cho, Oscar Francesconi, Nathalie Busschaert, Philip A Gale, Stefano Roelens, Jonathan L Sessler.   

Abstract

A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl(-) transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus in vitro.

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Year:  2016        PMID： 27223254      PMCID： PMC4911636          DOI： 10.1039/c6cc03645g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  16 in total

Review 1.  Recent advances in the transmembrane transport of anions.

Authors:  Jeffery T Davis; Oluyomi Okunola; Roberto Quesada
Journal:  Chem Soc Rev       Date:  2010-08-31       Impact factor: 54.564

Review 2.  Methicillin-resistant Staphylococcus aureus: an evolving pathogen.

Authors:  Martin E Stryjewski; G Ralph Corey
Journal:  Clin Infect Dis       Date:  2014-01       Impact factor: 9.079

3.  Ion-pair binding: is binding both binding better?

Authors:  Stefano Roelens; Alberto Vacca; Oscar Francesconi; Chiara Venturi
Journal:  Chemistry       Date:  2009-08-17       Impact factor: 5.236

Review 4.  Small-molecule lipid-bilayer anion transporters for biological applications.

Authors:  Nathalie Busschaert; Philip A Gale
Journal:  Angew Chem Int Ed Engl       Date:  2013-01-02       Impact factor: 15.336

5.  Aminopyrrolic synthetic receptors for monosaccharides: a class of carbohydrate-binding agents endowed with antibiotic activity versus pathogenic yeasts.

Authors:  Cristina Nativi; Oscar Francesconi; Gabriele Gabrielli; Irene De Simone; Benedetta Turchetti; Tommaso Mello; Lorenzo Di Cesare Mannelli; Carla Ghelardini; Pietro Buzzini; Stefano Roelens
Journal:  Chemistry       Date:  2012-03-05       Impact factor: 5.236

6.  Synthetic ion transporters that work with anion-π interactions, halogen bonds, and anion-macrodipole interactions.

Authors:  Andreas Vargas Jentzsch; Andreas Hennig; Jiri Mareda; Stefan Matile
Journal:  Acc Chem Res       Date:  2013-04-02       Impact factor: 22.384

7.  Binding of ionic species: a general approach to measuring binding constants and assessing affinities.

Authors:  Stefano Roelens; Alberto Vacca; Chiara Venturi
Journal:  Chemistry       Date:  2009-03-02       Impact factor: 5.236

8.  Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites.

Authors:  Dion A Kevin Ii; Damaris Af Meujo; Mark T Hamann
Journal:  Expert Opin Drug Discov       Date:  2009-02       Impact factor: 6.098

Review 9.  Synthetic ion channels: from pores to biological applications.

Authors:  George W Gokel; Saeedeh Negin
Journal:  Acc Chem Res       Date:  2013-06-05       Impact factor: 22.384

10.  Structure-activity relationships in tripodal transmembrane anion transporters: the effect of fluorination.

Authors:  Nathalie Busschaert; Marco Wenzel; Mark E Light; Paulina Iglesias-Hernández; Ricardo Pérez-Tomás; Philip A Gale
Journal:  J Am Chem Soc       Date:  2011-08-16       Impact factor: 15.419
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  3 in total

1.  A Class of Potent Inhibitors of the HIV-1 Nucleocapsid Protein Based on Aminopyrrolic Scaffolds.

Authors:  Stefano Ciaco; Nicolas Humbert; Eléonore Real; Christian Boudier; Oscar Francesconi; Stefano Roelens; Cristina Nativi; Carole Seguin-Devaux; Mattia Mori; Yves Mély
Journal:  ACS Med Chem Lett       Date:  2020-01-27       Impact factor: 4.345

2.  Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs.

Authors:  Hongyu Li; Hennie Valkenier; Abigail G Thorne; Christopher M Dias; James A Cooper; Marion Kieffer; Nathalie Busschaert; Philip A Gale; David N Sheppard; Anthony P Davis
Journal:  Chem Sci       Date:  2019-10-02       Impact factor: 9.825

Review 3.  Recent Advances in Bioactive Artificial Ionophores.

Authors:  Arundhati Roy; Pinaki Talukdar
Journal:  Chembiochem       Date:  2021-06-23       Impact factor: 3.164
  3 in total

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