Literature DB >> 27222636

Erratum to: Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth.

Huanan Wang1, Lei Wang2, Yingjie Zhang2, Ji Wang2, Yibin Deng2, Degui Lin3.   

Abstract

[This corrects the article DOI: 10.1186/s12935-016-0280-y.].

Entities:  

Year:  2016        PMID: 27222636      PMCID: PMC4878060          DOI: 10.1186/s12935-016-0313-6

Source DB:  PubMed          Journal:  Cancer Cell Int        ISSN: 1475-2867            Impact factor:   5.722


Erratum to: Cancer Cell Int (2016) 16:9 DOI 10.1186/s12935-016-0280-y

Following the publication of the original article [1] it was brought to our attention that there are a number of major errors within the text which were not picked up upon by the authors until after publication. The authors accidentally copied the same pictures in Fig. 1d and Fig. 2d, Fig. 1g and Fig. 2g. The following are the correct pictures for Fig. 1d and g.
Fig. 1

shRNA-mediated knockdown of oncogenic Kras reduces HK2 expression and suppresses growth in NSCLC cell lines. a, b Protein level of Kras and HK2 was detected in KP2 and H23 cells expressing shRNAs for Kras. c, d Clonogenic survival assays were performed to assess cell growth. Colonies were stained by crystal violet after 7 days of cell growth. e, f Xenograft tumor growth. 1 × 106 cells expressing scramble shRNA (CON) or shRNA for Kras were subcutaneously injected to the lower flank of NSG mice. Representative images of tumors at 4 weeks after injection are shown (e). Quantification of tumors weight (P < 0.01) (f). g IHC staining of cell proliferation marker Ki67 from control or Kras-knockdown KP2 cells. h Quantification of Ki67 expression from representative images shown in g (P < 0.01)

shRNA-mediated knockdown of oncogenic Kras reduces HK2 expression and suppresses growth in NSCLC cell lines. a, b Protein level of Kras and HK2 was detected in KP2 and H23 cells expressing shRNAs for Kras. c, d Clonogenic survival assays were performed to assess cell growth. Colonies were stained by crystal violet after 7 days of cell growth. e, f Xenograft tumor growth. 1 × 106 cells expressing scramble shRNA (CON) or shRNA for Kras were subcutaneously injected to the lower flank of NSG mice. Representative images of tumors at 4 weeks after injection are shown (e). Quantification of tumors weight (P < 0.01) (f). g IHC staining of cell proliferation marker Ki67 from control or Kras-knockdown KP2 cells. h Quantification of Ki67 expression from representative images shown in g (P < 0.01) These changes won’t affect any of the figure legends and conclusions.
  1 in total

1.  Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth.

Authors:  Huanan Wang; Lei Wang; Yingjie Zhang; Ji Wang; Yibin Deng; Degui Lin
Journal:  Cancer Cell Int       Date:  2016-02-16       Impact factor: 5.722

  1 in total
  2 in total

Review 1.  Dysregulation of metabolic enzymes in tumor and stromal cells: Role in oncogenesis and therapeutic opportunities.

Authors:  Mohammad Aslam Khan; Haseeb Zubair; Shashi Anand; Sanjeev Kumar Srivastava; Seema Singh; Ajay Pratap Singh
Journal:  Cancer Lett       Date:  2020-01-07       Impact factor: 8.679

2.  Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis.

Authors:  Wan-Chun Li; Chien-Hsiang Huang; Yi-Ta Hsieh; Tsai-Ying Chen; Li-Hao Cheng; Chang-Yi Chen; Chung-Ji Liu; Hsin-Ming Chen; Chien-Ling Huang; Jen-Fang Lo; Kuo-Wei Chang
Journal:  Front Oncol       Date:  2020-03-03       Impact factor: 6.244

  2 in total

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