Prasanna L Ponugoti1, Douglas K Rex1. 1. Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Abstract
BACKGROUND AND AIMS: Current guidelines recommend screening colonoscopy at 10-year intervals in average-risk individuals who had baseline screening colonoscopy (no polyps or only hyperplastic polyps ≤5 mm in the recto-sigmoid colon), but the yield of repeat screening at 10 years is unknown. Our aim was to describe the yield of second screening colonoscopy in average-risk individuals performed at least 8 years after a first screening colonoscopy had shown no polyps or only distal hyperplastic polyps ≤5 mm in size. METHODS: This was a review of a database for colonoscopies performed at Indiana University Hospital between January 1999 and November 2015. RESULTS: A total of 4463 individuals underwent screening colonoscopy between January 1999 and July 2007, of which 1566 individuals had no polyps, and 334 individuals had only distal hyperplastic polyps ≤5 mm; 378 individuals (58.4% female) had follow-up screening at least 8 years after the baseline screening examination, with a mean (± standard deviation [SD]) interval of 9.74 years (± 1.2 years; range 8-15 years). Mean (± SD) age at baseline screening examination was 56.7 years (± 5.5 years) and at follow-up screening examination was 66.4 years (± 5.6 years). At the second screening, there were 224 patients (59.3%) with at least 1 polyp, including 144 (38.1%) with at least 1 conventional adenoma. The adenoma detection rate at the second screening examination was 36.1% and 56.8% in the groups with no polyp at baseline and with only distal hyperplastic polyps, respectively. There were 15 advanced neoplasms in 13 individuals (3.4%), of which 12 lesions were proximal to the sigmoid colon. There were no cancers at follow-up. CONCLUSIONS: Among individuals aged ≥50 years, with normal baseline screening colonoscopy results, the incidence of advanced lesions at a second screening colonoscopy at least 8 years later was comparable to that in baseline screening studies. Our findings support current recommendations for screening at 10-year intervals in average-risk individuals.
BACKGROUND AND AIMS: Current guidelines recommend screening colonoscopy at 10-year intervals in average-risk individuals who had baseline screening colonoscopy (no polyps or only hyperplastic polyps ≤5 mm in the recto-sigmoid colon), but the yield of repeat screening at 10 years is unknown. Our aim was to describe the yield of second screening colonoscopy in average-risk individuals performed at least 8 years after a first screening colonoscopy had shown no polyps or only distal hyperplastic polyps ≤5 mm in size. METHODS: This was a review of a database for colonoscopies performed at Indiana University Hospital between January 1999 and November 2015. RESULTS: A total of 4463 individuals underwent screening colonoscopy between January 1999 and July 2007, of which 1566 individuals had no polyps, and 334 individuals had only distal hyperplastic polyps ≤5 mm; 378 individuals (58.4% female) had follow-up screening at least 8 years after the baseline screening examination, with a mean (± standard deviation [SD]) interval of 9.74 years (± 1.2 years; range 8-15 years). Mean (± SD) age at baseline screening examination was 56.7 years (± 5.5 years) and at follow-up screening examination was 66.4 years (± 5.6 years). At the second screening, there were 224 patients (59.3%) with at least 1 polyp, including 144 (38.1%) with at least 1 conventional adenoma. The adenoma detection rate at the second screening examination was 36.1% and 56.8% in the groups with no polyp at baseline and with only distal hyperplastic polyps, respectively. There were 15 advanced neoplasms in 13 individuals (3.4%), of which 12 lesions were proximal to the sigmoid colon. There were no cancers at follow-up. CONCLUSIONS: Among individuals aged ≥50 years, with normal baseline screening colonoscopy results, the incidence of advanced lesions at a second screening colonoscopy at least 8 years later was comparable to that in baseline screening studies. Our findings support current recommendations for screening at 10-year intervals in average-risk individuals.
Authors: Lisanne S Rigter; Manon C W Spaander; Berthe M P Aleman; Tanya M Bisseling; Leon M Moons; Annemieke Cats; Pieternella J Lugtenburg; Cecile P M Janus; Eefke J Petersen; Judith M Roesink; Richard W M van der Maazen; Petur Snaebjornsson; Ernst J Kuipers; Marco J Bruno; Evelien Dekker; Gerrit A Meijer; Jan Paul de Boer; Flora E van Leeuwen; Monique E van Leerdam Journal: Cancer Date: 2018-12-18 Impact factor: 6.860
Authors: Berbel L M Ykema; Tanya M Bisseling; Manon C W Spaander; Leon M G Moons; Dorien van der Biessen-van Beek; Lisette Saveur; Martijn Kerst; Sasja F Mulder; Ronald de Wit; Danielle Zweers; Gerrit A Meijer; Jos H Beijnen; Iris Lansdorp-Vogelaar; Flora E van Leeuwen; Petur Snaebjornsson; Monique E van Leerdam Journal: BMC Gastroenterol Date: 2021-02-12 Impact factor: 3.067