OBJECTIVE: : We performed 123I-meta-iodobenzylguanidine (123I-MIBG) myocardial scintigraphy for the diagnosis of Lewy body disease (LBD) and assessed whether the early heart-to-mediastinum (H/M) ratio was diagnostic and whether visual image analysis was useful. METHODS: : Our study included 453 patients with clinically suspected LBD who had undergone 123I-MIBG myocardial scintigraphy. We evaluated semi-quantitative values (early and delayed H/M ratio, washout rate) and performed visual image analysis. The sensitivity, specificity, accuracy, positive-predictive value (PPV) and negative-predictive value (NPV) of both analyses were calculated. RESULTS: : The early H/M ratio exhibited the best diagnostic ability. Its overall sensitivity, specificity, accuracy, PPV and NPV were 72.2%, 93.1%, 84.3%, 88.5% and 82.2%, respectively (cut-off value 2.2 or less). However, there was no significant difference from the delayed H/M ratio or the results of visual assessment. CONCLUSION: : 123I-MIBG myocardial scintigraphy accurately differentiates between patients with and without LBD and a correct diagnosis can be established based on the early H/M ratio. We also document that visual evaluation of scintigrams is useful. Therefore, patients may benefit from the single performance of the procedure because a correct diagnosis can be obtained early in the disease process and their prognosis and appropriate treatment can be determined. ADVANCES IN KNOWLEDGE:: 123I-MIBG myocardial scintigraphy on the early H/M ratio makes it possible to differentiate between patients with LBD and patients without LBD.
OBJECTIVE: : We performed 123I-meta-iodobenzylguanidine (123I-MIBG) myocardial scintigraphy for the diagnosis of Lewy body disease (LBD) and assessed whether the early heart-to-mediastinum (H/M) ratio was diagnostic and whether visual image analysis was useful. METHODS: : Our study included 453 patients with clinically suspected LBD who had undergone 123I-MIBG myocardial scintigraphy. We evaluated semi-quantitative values (early and delayed H/M ratio, washout rate) and performed visual image analysis. The sensitivity, specificity, accuracy, positive-predictive value (PPV) and negative-predictive value (NPV) of both analyses were calculated. RESULTS: : The early H/M ratio exhibited the best diagnostic ability. Its overall sensitivity, specificity, accuracy, PPV and NPV were 72.2%, 93.1%, 84.3%, 88.5% and 82.2%, respectively (cut-off value 2.2 or less). However, there was no significant difference from the delayed H/M ratio or the results of visual assessment. CONCLUSION: : 123I-MIBG myocardial scintigraphy accurately differentiates between patients with and without LBD and a correct diagnosis can be established based on the early H/M ratio. We also document that visual evaluation of scintigrams is useful. Therefore, patients may benefit from the single performance of the procedure because a correct diagnosis can be obtained early in the disease process and their prognosis and appropriate treatment can be determined. ADVANCES IN KNOWLEDGE:: 123I-MIBG myocardial scintigraphy on the early H/M ratio makes it possible to differentiate between patients with LBD and patients without LBD.
Authors: M S Stanton; M M Tuli; N L Radtke; J J Heger; W M Miles; B H Mock; R W Burt; H N Wellman; D P Zipes Journal: J Am Coll Cardiol Date: 1989-11-15 Impact factor: 24.094
Authors: Martin Köllensperger; Klaus Seppi; Claudia Liener; Sylvia Boesch; Dirk Heute; Katherina J Mair; Joerg Mueller; Martin Sawires; Christoph Scherfler; Michael F Schocke; Eveline Donnemilier; Irene Virgolini; Gregor K Wenning; Werner Poewe Journal: Mov Disord Date: 2007-09-15 Impact factor: 10.338
Authors: Gemma Roberts; Joseph P M Kane; Jim Lloyd; Michael Firbank; Paul Christopher Donaghy; George S Petrides; John-Paul Taylor; John O'Brien; Alan J Thomas Journal: Nucl Med Commun Date: 2022-05-20 Impact factor: 1.698
Authors: G Roberts; J J Lloyd; J P M Kane; R Durcan; S Lawley; K Howe; G S Petrides; J T O'Brien; A J Thomas Journal: J Nucl Cardiol Date: 2019-09-16 Impact factor: 5.952