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Literature DB >> 27220646

Fishing for Function in the Human Gene Pool.

Iros Barozzi¹, Axel Visel², Diane E Dickel³.

Abstract

Identification and characterization of causal non-coding variants in human genomes is challenging and requires substantial experimental resources. A new study by Tehranchi et al. describes a cost-effective approach for accurate mapping of molecular quantitative trait loci (QTLs) from pooled samples, a powerful way to link disease-associated changes to molecular functions.

Entities: Disease Gene Species

Keywords: GWAS; QTL; cis-regulation; non-coding DNA

Mesh：

Year: 2016 PMID： 27220646 PMCID： PMC4912909 DOI： 10.1016/j.tig.2016.05.002

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

Keyword Cloud
References

10 in total

1. Population Variation and Genetic Control of Modular Chromatin Architecture in Humans.

Authors: Sebastian M Waszak; Olivier Delaneau; Andreas R Gschwind; Helena Kilpinen; Sunil K Raghav; Robert M Witwicki; Andrea Orioli; Michael Wiederkehr; Nikolaos I Panousis; Alisa Yurovsky; Luciana Romano-Palumbo; Alexandra Planchon; Deborah Bielser; Ismael Padioleau; Gilles Udin; Sarah Thurnheer; David Hacker; Nouria Hernandez; Alexandre Reymond; Bart Deplancke; Emmanouil T Dermitzakis
Journal: Cell Date: 2015-08-20 Impact factor: 41.582

2. Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk.

Authors: Ashley K Tehranchi; Marsha Myrthil; Trevor Martin; Brian L Hie; David Golan; Hunter B Fraser
Journal: Cell Date: 2016-04-14 Impact factor: 41.582

3. A map of human genome variation from population-scale sequencing.

Authors: Gonçalo R Abecasis; David Altshuler; Adam Auton; Lisa D Brooks; Richard M Durbin; Richard A Gibbs; Matt E Hurles; Gil A McVean
Journal: Nature Date: 2010-10-28 Impact factor: 49.962

4. Genetic Control of Chromatin States in Humans Involves Local and Distal Chromosomal Interactions.

Authors: Fabian Grubert; Judith B Zaugg; Maya Kasowski; Oana Ursu; Damek V Spacek; Alicia R Martin; Peyton Greenside; Rohith Srivas; Doug H Phanstiel; Aleksandra Pekowska; Nastaran Heidari; Ghia Euskirchen; Wolfgang Huber; Jonathan K Pritchard; Carlos D Bustamante; Lars M Steinmetz; Anshul Kundaje; Michael Snyder
Journal: Cell Date: 2015-08-20 Impact factor: 41.582

5. Chromatin marks identify critical cell types for fine mapping complex trait variants.

Authors: Gosia Trynka; Cynthia Sandor; Buhm Han; Han Xu; Barbara E Stranger; X Shirley Liu; Soumya Raychaudhuri
Journal: Nat Genet Date: 2012-12-23 Impact factor: 38.330

6. Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.

Authors: Helena Kilpinen; Sebastian M Waszak; Andreas R Gschwind; Sunil K Raghav; Robert M Witwicki; Andrea Orioli; Eugenia Migliavacca; Michaël Wiederkehr; Maria Gutierrez-Arcelus; Nikolaos I Panousis; Alisa Yurovsky; Tuuli Lappalainen; Luciana Romano-Palumbo; Alexandra Planchon; Deborah Bielser; Julien Bryois; Ismael Padioleau; Gilles Udin; Sarah Thurnheer; David Hacker; Leighton J Core; John T Lis; Nouria Hernandez; Alexandre Reymond; Bart Deplancke; Emmanouil T Dermitzakis
Journal: Science Date: 2013-10-17 Impact factor: 47.728

Fishing for Function in the Human Gene Pool.

1. Population Variation and Genetic Control of Modular Chromatin Architecture in Humans.

2. Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk.

3. A map of human genome variation from population-scale sequencing.

4. Genetic Control of Chromatin States in Humans Involves Local and Distal Chromosomal Interactions.

5. Chromatin marks identify critical cell types for fine mapping complex trait variants.

6. Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.

7. A pooling-based approach to mapping genetic variants associated with DNA methylation.

8. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations.

9. Identification of genetic variants that affect histone modifications in human cells.

10. An integrated encyclopedia of DNA elements in the human genome.