Literature DB >> 27217912

Point-of-care lactate and creatinine analysis for sick obstetric patients at Queen Elizabeth Central Hospital in Blantyre, Malawi: A feasibility study.

S A Glasmacher1, P Bonongwe2, W Stones3.   

Abstract

BACKGROUND: To achieve good outcomes in critically ill obstetric patients, it is necessary to identify organ dysfunction rapidly so that life-saving interventions can be appropriately commenced. However, timely access to clinical chemistry results is problematic, even in referral institutions, in the sub-Saharan African region. Reliable point-of-care tests licensed for clinical use are now available for lactate and creatinine. AIM: We aimed to assess whether implementation of point-of-care testing for lactate and creatinine is feasible in the obstetric unit at the Queen Elizabeth Central Hospital (QECH) in Blantyre, Malawi, by obtaining the opinions of clinical staff on the use of these tests in practice.
METHODS: During a two-month evaluation period nurse-midwives, medical interns, clinical officers, registrars, and consultants were given the opportunity to use StatStrip® and StatSensor® (Nova Biomedical, Waltham, USA) devices, for lactate and creatinine estimation, as part of their routine clinical practice in the obstetric unit. They were subsequently asked to complete a short questionnaire.
RESULTS: Thirty-seven questionnaires were returned by participants: 22 from nurse-midwives and the remainder from clinicians. The mean satisfaction score for the devices was 7.6/10 amongst clinicians and 8.0/10 amongst nurse-midwives. The majority of participants stated that the obstetric high dependency unit (HDU) was the most suitable location for the devices. For lactate, 31 participants strongly agreed that testing should be continued and 24 strongly agreed that it would influence patient management. For creatinine, 29 strongly agreed that testing should be continued and 28 strongly agreed that it would influence their patient management. Twenty participants strongly agreed that they trust point-of-care devices.
CONCLUSIONS: Point-of-care clinical chemistry testing was feasible, practical, and well received by staff, and was considered to have a useful role to play in the clinical care of sick obstetric patients at this referral centre.

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Year:  2016        PMID: 27217912      PMCID: PMC4864387          DOI: 10.4314/mmj.v28i1.4

Source DB:  PubMed          Journal:  Malawi Med J        ISSN: 1995-7262            Impact factor:   0.875


  18 in total

Review 1.  Point of care testing.

Authors:  C P Price
Journal:  BMJ       Date:  2001-05-26

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Authors:  Mark J Acierno; Meghan E Johnson; Lee Ann Eddleman; Mark A Mitchell
Journal:  J Feline Med Surg       Date:  2007-10-01       Impact factor: 2.015

3.  Determinants of post-partum maternal mortality at Queen Elizabeth Central Hospital, Blantyre, Malawi: a case-control study 2001-2002.

Authors:  C Kanyighe; A Channon; E Tadesse; N Madise; J Changole; E Bakuwa; E Malunga; R W Stones
Journal:  Afr J Reprod Health       Date:  2008-12

4.  ED bedside point-of-care lactate in patients with suspected sepsis is associated with reduced time to iv fluids and mortality.

Authors:  Adam J Singer; Maria Taylor; Debra LeBlanc; Justin Williams; Henry C Thode
Journal:  Am J Emerg Med       Date:  2014-07-01       Impact factor: 2.469

5.  Point-of-care measurement of blood lactate in children admitted with febrile illness to an African District Hospital.

Authors:  George Mtove; Behzad Nadjm; Ilse C E Hendriksen; Ben Amos; Florida Muro; Jim Todd; Hugh Reyburn
Journal:  Clin Infect Dis       Date:  2011-09       Impact factor: 9.079

6.  Evaluation of the analytical performance of the nova StatSensor creatinine meter for blood testing.

Authors:  Chayanit Srihong; Kavinyanee Pangsapa; Kanyaorn Chuaboonmee; Yongyuth Kotipan; Navapun Charuruks
Journal:  J Med Assoc Thai       Date:  2012-09

7.  Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial.

Authors:  Tim C Jansen; Jasper van Bommel; F Jeanette Schoonderbeek; Steven J Sleeswijk Visser; Johan M van der Klooster; Alex P Lima; Sten P Willemsen; Jan Bakker
Journal:  Am J Respir Crit Care Med       Date:  2010-05-12       Impact factor: 21.405

8.  Point-of-care lactate testing predicts mortality of severe sepsis in a predominantly HIV type 1-infected patient population in Uganda.

Authors:  Christopher C Moore; Shevin T Jacob; Relana Pinkerton; David B Meya; Harriet Mayanja-Kizza; Steven J Reynolds; W Michael Scheld
Journal:  Clin Infect Dis       Date:  2008-01-15       Impact factor: 9.079

9.  Increased aerobic glycolysis through beta2 stimulation is a common mechanism involved in lactate formation during shock states.

Authors:  Bruno Levy; Olivier Desebbe; Chantal Montemont; Sebastien Gibot
Journal:  Shock       Date:  2008-10       Impact factor: 3.454

Review 10.  Blood lactate as a predictor for in-hospital mortality in patients admitted acutely to hospital: a systematic review.

Authors:  Ole Kruse; Niels Grunnet; Charlotte Barfod
Journal:  Scand J Trauma Resusc Emerg Med       Date:  2011-12-28       Impact factor: 2.953

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  5 in total

1.  Biochemical derangements prior to emergency laparotomy at Queen Elizabeth Central Hospital, Blantyre, Malawi: A cross-sectional pilot study.

Authors:  Mark G Williams
Journal:  Malawi Med J       Date:  2017-03       Impact factor: 0.875

2.  mSep: investigating physiological and immune-metabolic biomarkers in septic and healthy pregnant women to predict feto-maternal immune health - a prospective observational cohort study protocol.

Authors:  Simran Sharma; Summia Zaher; Patrícia R S Rodrigues; Luke C Davies; Sarah Edkins; Angela Strang; Mallinath Chakraborty; W John Watkins; Robert Andrews; Edward Parkinson; Nicos Angelopoulos; Linda Moet; Freya Shepherd; Kate Megan Megan Davies; Daniel White; Shaun Oram; Kate Siddall; Vikki Keeping; Kathryn Simpson; Federica Faggian; Maryanne Bray; Claire Bertorelli; Sarah Bell; Rachel E Collis; James E McLaren; Mario Labeta; Valerie B O'Donnell; Peter Ghazal
Journal:  BMJ Open       Date:  2022-09-17       Impact factor: 3.006

Review 3.  A systematic review and diagnostic test accuracy meta-analysis of the validity of anion gap as a screening tool for hyperlactatemia.

Authors:  Stella Andrea Glasmacher; William Stones
Journal:  BMC Res Notes       Date:  2017-11-03

4.  Point-of-care umbilical arterial lactate and newborn outcomes in a low resource setting: cohort study.

Authors:  George Kassim Chilinda; Luis Aaron Gadama; William Stones
Journal:  BMC Res Notes       Date:  2018-07-16

5.  The utility of point of care serum lactate in predicting serious adverse outcomes among critically ill adult patients at urban emergency departments of tertiary hospitals in Tanzania.

Authors:  Uwezo Edward; Hendry R Sawe; Juma A Mfinanga; Theresia A Ottaru; Michael Kiremeji; Deus N Kitapondya; Dereck A Kaale; Asha Iyullu; Nicks Bret; Ellen J Weber
Journal:  Trop Med Health       Date:  2019-12-27
  5 in total

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