H G Ren1, H N Luu2, H Cai3, Y B Xiang4, M Steinwandel5, Y T Gao4, M Hargreaves6, W Zheng3, W J Blot7, J R Long3, X O Shu8. 1. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA Institution of Hematology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 2. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, USA. 3. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA. 4. Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong, University School of Medicine, Shanghai, China. 5. International Epidemiology Institute, Rockville. 6. Department of Internal Medicine, Meharry Medical College, Nashville, USA. 7. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA International Epidemiology Institute, Rockville. 8. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA xiao-ou.shu@vanderbilt.edu.
Abstract
BACKGROUND: While studies have shown that poor oral health status may increase the risk of cancer, evidence of a specific association with the risk of colorectal cancer (CRC) is inconclusive. We evaluated the association between oral health and CRC risk using data from three large cohorts: the Shanghai Men's Health Study (SMHS), the Shanghai Women's Health Study (SWHS), and the Southern Community Cohort Study (SCCS), and carried out a meta-analysis of results from other relevant published studies. PATIENTS AND METHODS: This study applied a nested case-control study design and included 825 cases/3298 controls from the SMHS/SWHS and 238 cases/2258 controls from the SCCS. The association between oral health status (i.e. tooth loss/tooth decay) and CRC risk was assessed using conditional logistic regression models. A meta-analysis was carried out based on results from the present study and three published studies. RESULTS: We found that tooth loss was not associated with increased risk of CRC. ORs and respective 95% CIs associated with loss of 1-5, 6-10, and >10 teeth compared with those with full teeth are 0.87 (0.69-1.10), 0.93 (0.70-1.24), and 0.85 (0.66-1.11) among SMHS/SWHS participants; and 1.13 (0.72-1.79), 0.87 (0.52-1.43), and 1.00 (0.63-1.58) for those with loss of 1-4, 5-10, and >10 teeth among SCCS participants. Data regarding tooth decay were available in the SCCS, but were not associated with CRC risk. Meta-analysis confirmed the null association between tooth loss/periodontal disease and CRC risk (OR 1.05, 95% CI 0.86-1.29). CONCLUSION: In this analysis of three cohorts and a meta-analysis, we found no evidence supporting an association between oral health and CRC risk.
BACKGROUND: While studies have shown that poor oral health status may increase the risk of cancer, evidence of a specific association with the risk of colorectal cancer (CRC) is inconclusive. We evaluated the association between oral health and CRC risk using data from three large cohorts: the Shanghai Men's Health Study (SMHS), the Shanghai Women's Health Study (SWHS), and the Southern Community Cohort Study (SCCS), and carried out a meta-analysis of results from other relevant published studies. PATIENTS AND METHODS: This study applied a nested case-control study design and included 825 cases/3298 controls from the SMHS/SWHS and 238 cases/2258 controls from the SCCS. The association between oral health status (i.e. tooth loss/tooth decay) and CRC risk was assessed using conditional logistic regression models. A meta-analysis was carried out based on results from the present study and three published studies. RESULTS: We found that tooth loss was not associated with increased risk of CRC. ORs and respective 95% CIs associated with loss of 1-5, 6-10, and >10 teeth compared with those with full teeth are 0.87 (0.69-1.10), 0.93 (0.70-1.24), and 0.85 (0.66-1.11) among SMHS/SWHS participants; and 1.13 (0.72-1.79), 0.87 (0.52-1.43), and 1.00 (0.63-1.58) for those with loss of 1-4, 5-10, and >10 teeth among SCCS participants. Data regarding tooth decay were available in the SCCS, but were not associated with CRC risk. Meta-analysis confirmed the null association between tooth loss/periodontal disease and CRC risk (OR 1.05, 95% CI 0.86-1.29). CONCLUSION: In this analysis of three cohorts and a meta-analysis, we found no evidence supporting an association between oral health and CRC risk.
Authors: Aleksandar D Kostic; Eunyoung Chun; Lauren Robertson; Jonathan N Glickman; Carey Ann Gallini; Monia Michaud; Thomas E Clancy; Daniel C Chung; Paul Lochhead; Georgina L Hold; Emad M El-Omar; Dean Brenner; Charles S Fuchs; Matthew Meyerson; Wendy S Garrett Journal: Cell Host Microbe Date: 2013-08-14 Impact factor: 21.023
Authors: Haydée Wt Jordão; Gerry McKenna; Úna C McMenamin; Andrew T Kunzmann; Liam J Murray; Helen G Coleman Journal: United European Gastroenterol J Date: 2019-06-08 Impact factor: 4.623
Authors: Chun-Han Lo; Long H Nguyen; Kana Wu; Shuji Ogino; Andrew T Chan; Edward L Giovannucci; Mingyang Song Journal: Cancer Prev Res (Phila) Date: 2020-08
Authors: Yaohua Yang; Qiuyin Cai; Xiao-Ou Shu; Mark D Steinwandel; William J Blot; Wei Zheng; Jirong Long Journal: Int J Cancer Date: 2018-12-11 Impact factor: 7.396
Authors: Laura Corlin; Mengyuan Ruan; Konstantinos K Tsilidis; Emmanouil Bouras; Yau-Hua Yu; Rachael Stolzenberg-Solomon; Alison P Klein; Harvey A Risch; Christopher I Amos; Lori C Sakoda; Pavel Vodička; Pai K Rish; James Beck; Elizabeth A Platz; Dominique S Michaud Journal: JNCI Cancer Spectr Date: 2021-04-19