Literature DB >> 2721636

VLDL substrate properties and efficiency of their metabolic transformation by LPL.

A D Dergunov1, V V Shuvaev, N V Perova.   

Abstract

A study was made of the regulation of the triglyceride hydrolysis catalysed by LPL from bovine milk, by the apoproteins from human plasma VLDL. Both isolated apolipoproteins, and those found on the surface of plasma VLDL particles, were investigated. A concentration-dependent activating action of apo C-II on the hydrolysis of emulsified triolein, and uncompetitive inhibition of VLDL triglyceride hydrolysis by apo C-III were found. It is suggested that VLDL lipolysis might be controlled in vivo through the variation of the relative surface content of these enzymatic activity modulators.

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Year:  1989        PMID: 2721636     DOI: 10.1007/BF01952030

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  11 in total

1.  The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.

Authors:  R J HAVEL; H A EDER; J H BRAGDON
Journal:  J Clin Invest       Date:  1955-09       Impact factor: 14.808

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Purification of bovine milk lipoprotein lipase with the aid of detergent.

Authors:  P K Kinnunen
Journal:  Med Biol       Date:  1977-06

4.  [Protein-lipid interaction in very low density lipoproteins from human plasma].

Authors:  A D Dergunov; V V Shuvaev; N V Perova
Journal:  Dokl Akad Nauk SSSR       Date:  1988

Review 5.  Apoprotein C metabolism in man.

Authors:  P J Nestel; N H Fidge
Journal:  Adv Lipid Res       Date:  1982

6.  [Kinetics of triolein hydrolysis by lipoprotein lipase in the presence of apoprotein C-II].

Authors:  A D Dergunov; V V Shuvaev; A A Sokol'nikov; V A Metel'skaia; N V Perova
Journal:  Dokl Akad Nauk SSSR       Date:  1985 Mar-Apr

7.  Action of lipoprotein lipase on phospholipid monolayers. Activation by apolipoprotein C-II.

Authors:  P Vainio; J A Virtanen; P K Kinnunen; J C Voyta; L C Smith; A M Gotto; J T Sparrow; F Pattus; R Verger
Journal:  Biochemistry       Date:  1983-04-26       Impact factor: 3.162

8.  Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III.

Authors:  C S Wang; W J McConathy; H U Kloer; P Alaupovic
Journal:  J Clin Invest       Date:  1985-02       Impact factor: 14.808

9.  Kinetics of bovine milk lipoprotein lipase and the mechanism of enzyme activation by apolipoprotein C-II.

Authors:  I Posner; C S Wang; W J McConathy
Journal:  Biochemistry       Date:  1983-08-16       Impact factor: 3.162

10.  Preparation and properties of immobilized lipoprotein lipase.

Authors:  N Matsuoka; K Shirai; R L Jackson
Journal:  Biochim Biophys Acta       Date:  1980-11-07
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