Literature DB >> 27216066

Binding of Daptomycin to Anionic Lipid Vesicles Is Reduced in the Presence of Lysyl-Phosphatidylglycerol.

Tala O Khatib1, Heather Stevenson1, Michael R Yeaman2, Arnold S Bayer3, Antje Pokorny4.   

Abstract

The cytoplasmic membrane of Staphylococcus aureus contains ∼20 mol% of the net cationic lipid lysyl-phosphatidylglycerol (LPG). Elevated fractions of LPG are associated with increased resistance to cationic antibiotics, including the lipopeptide daptomycin (DAP). Although the surface charge of the bacterial cytoplasmic membrane is altered by LPG, surface binding of DAP was found to be only moderately affected in anionic vesicles containing 20 mol% LPG. These results suggest that charge repulsion cannot fully explain LPG-mediated resistance to cationic peptides.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27216066      PMCID： PMC4958220          DOI： 10.1128/AAC.00744-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

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Authors:  Paulo F Almeida; Antje Pokorny
Journal:  Methods Mol Biol       Date:  2010

2.  DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model.

Authors:  Christopher Weidenmaier; Andreas Peschel; Volkhard A J Kempf; Natalie Lucindo; Michael R Yeaman; Arnold S Bayer
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

3.  The MprF protein is required for lysinylation of phospholipids in listerial membranes and confers resistance to cationic antimicrobial peptides (CAMPs) on Listeria monocytogenes.

Authors:  Kathrin Thedieck; Torsten Hain; Walid Mohamed; Brian J Tindall; Manfred Nimtz; Trinad Chakraborty; Jürgen Wehland; Lothar Jänsch
Journal:  Mol Microbiol       Date:  2006-10-17       Impact factor: 3.501

4.  Lysylated phospholipids stabilize models of bacterial lipid bilayers and protect against antimicrobial peptides.

Authors:  Elizabeth Cox; Austen Michalak; Sarah Pagentine; Pamela Seaton; Antje Pokorny
Journal:  Biochim Biophys Acta       Date:  2014-04-26

5.  Reduced content of lysyl-phosphatidylglycerol in the cytoplasmic membrane affects susceptibility to moenomycin, as well as vancomycin, gentamicin, and antimicrobial peptides, in Staphylococcus aureus.

Authors:  Hiromi Nishi; Hitoshi Komatsuzawa; Tamaki Fujiwara; Nadine McCallum; Motoyuki Sugai
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

Review 6.  Natural products to drugs: daptomycin and related lipopeptide antibiotics.

Authors:  Richard H Baltz; Vivian Miao; Stephen K Wrigley
Journal:  Nat Prod Rep       Date:  2005-11-04       Impact factor: 13.423

7.  Lysyl-phosphatidylglycerol attenuates membrane perturbation rather than surface association of the cationic antimicrobial peptide 6W-RP-1 in a model membrane system: implications for daptomycin resistance.

Authors:  Erin Kilelee; Antje Pokorny; Michael R Yeaman; Arnold S Bayer
Journal:  Antimicrob Agents Chemother       Date:  2010-07-26       Impact factor: 5.191

8.  MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance.

Authors:  Petra Staubitz; Heinz Neumann; Tanja Schneider; Imke Wiedemann; Andreas Peschel
Journal:  FEMS Microbiol Lett       Date:  2004-02-09       Impact factor: 2.742

9.  Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus.

Authors:  Nagendra N Mishra; Soo-Jin Yang; Ayumi Sawa; Aileen Rubio; Cynthia C Nast; Michael R Yeaman; Arnold S Bayer
Journal:  Antimicrob Agents Chemother       Date:  2009-03-30       Impact factor: 5.191

10.  Increased cell wall teichoic acid production and D-alanylation are common phenotypes among daptomycin-resistant methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates.

Authors:  Ute Bertsche; Soo-Jin Yang; Daniel Kuehner; Stefanie Wanner; Nagendra N Mishra; Tobias Roth; Mulugeta Nega; Alexander Schneider; Christoph Mayer; Timo Grau; Arnold S Bayer; Christopher Weidenmaier
Journal:  PLoS One       Date:  2013-06-13       Impact factor: 3.240
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  6 in total

1.  Daptomycin Resistance and Tolerance Due to Loss of Function in Staphylococcus aureus dsp1 and asp23.

Authors:  Elaine M Barros; Melissa J Martin; Elizabeth M Selleck; François Lebreton; Jorge Luiz M Sampaio; Michael S Gilmore
Journal:  Antimicrob Agents Chemother       Date:  2018-12-21       Impact factor: 5.191

2.  Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains.

Authors:  Anna Müller; Michaela Wenzel; Henrik Strahl; Fabian Grein; Terrens N V Saaki; Bastian Kohl; Tjalling Siersma; Julia E Bandow; Hans-Georg Sahl; Tanja Schneider; Leendert W Hamoen
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-24       Impact factor: 11.205

3.  Environment Shapes the Accessible Daptomycin Resistance Mechanisms in Enterococcus faecium.

Authors:  Amy G Prater; Heer H Mehta; Abigael J Kosgei; William R Miller; Truc T Tran; Cesar A Arias; Yousif Shamoo
Journal:  Antimicrob Agents Chemother       Date:  2019-09-23       Impact factor: 5.191

4.  Cationic Amphipathic Antimicrobial Peptides Perturb the Inner Membrane of Germinated Spores Thus Inhibiting Their Outgrowth.

Authors:  Soraya Omardien; Jan Wouter Drijfhout; Sebastian A Zaat; Stanley Brul
Journal:  Front Microbiol       Date:  2018-09-26       Impact factor: 5.640

5.  Flowering Poration-A Synergistic Multi-Mode Antibacterial Mechanism by a Bacteriocin Fold.

Authors:  Katharine Hammond; Helen Lewis; Samantha Halliwell; Florie Desriac; Brunello Nardone; Jascindra Ravi; Bart W Hoogenboom; Mathew Upton; Jeremy P Derrick; Maxim G Ryadnov
Journal:  iScience       Date:  2020-07-30

6.  Induction of Daptomycin Tolerance in Enterococcus faecalis by Fatty Acid Combinations.

Authors:  William Brewer; Johnathan Harrison; Holly E Saito; Elizabeth M Fozo
Journal:  Appl Environ Microbiol       Date:  2020-10-01       Impact factor: 4.792
  6 in total

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