Literature DB >> 20660664

Lysyl-phosphatidylglycerol attenuates membrane perturbation rather than surface association of the cationic antimicrobial peptide 6W-RP-1 in a model membrane system: implications for daptomycin resistance.

Erin Kilelee1, Antje Pokorny, Michael R Yeaman, Arnold S Bayer.   

Abstract

The presence of the cationic phospholipid lysyl-phosphatidylglycerol (lysyl-PG) in staphylococcal cytoplasmic membranes has been linked to increased resistance to cationic compounds, including antibiotics such as daptomycin as well as host defense antimicrobial peptides. We investigated the effects of lysyl-PG on binding of 6W-RP-1, a synthetic antimicrobial peptide, to lipid vesicles and on peptide-induced membrane permeabilization. Unexpectedly, physiological lysyl-PG concentrations only minimally reduced membrane binding of 6W-RP-1. In contrast, 6W-RP-1-induced dye leakage was severely inhibited by lysyl-PG, suggesting that lysyl-PG primarily impacts membrane defect formation.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20660664      PMCID： PMC2944598          DOI： 10.1128/AAC.00191-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Identification of a bacterial phospholipid as an O-ornithine ester of phosphatidyl glycerol.

Authors:  U M HOUTSMULLER; L van DEENEN
Journal:  Biochim Biophys Acta       Date:  1963-04-23

2.  A quantitative model for the all-or-none permeabilization of phospholipid vesicles by the antimicrobial peptide cecropin A.

Authors:  Sonia M Gregory; Allison Cavenaugh; Velvet Journigan; Antje Pokorny; Paulo F F Almeida
Journal:  Biophys J       Date:  2007-10-05       Impact factor: 4.033

3.  DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model.

Authors:  Christopher Weidenmaier; Andreas Peschel; Volkhard A J Kempf; Natalie Lucindo; Michael R Yeaman; Arnold S Bayer
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

4.  The MprF protein is required for lysinylation of phospholipids in listerial membranes and confers resistance to cationic antimicrobial peptides (CAMPs) on Listeria monocytogenes.

Authors:  Kathrin Thedieck; Torsten Hain; Walid Mohamed; Brian J Tindall; Manfred Nimtz; Trinad Chakraborty; Jürgen Wehland; Lothar Jänsch
Journal:  Mol Microbiol       Date:  2006-10-17       Impact factor: 3.501

5.  Reduced content of lysyl-phosphatidylglycerol in the cytoplasmic membrane affects susceptibility to moenomycin, as well as vancomycin, gentamicin, and antimicrobial peptides, in Staphylococcus aureus.

Authors:  Hiromi Nishi; Hitoshi Komatsuzawa; Tamaki Fujiwara; Nadine McCallum; Motoyuki Sugai
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

6.  Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding.

Authors:  Tiffanny Jones; Michael R Yeaman; George Sakoulas; Soo-Jin Yang; Richard A Proctor; Hans-Georg Sahl; Jacques Schrenzel; Yan Q Xiong; Arnold S Bayer
Journal:  Antimicrob Agents Chemother       Date:  2007-10-22       Impact factor: 5.191

7.  MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance.

Authors:  Petra Staubitz; Heinz Neumann; Tanja Schneider; Imke Wiedemann; Andreas Peschel
Journal:  FEMS Microbiol Lett       Date:  2004-02-09       Impact factor: 2.742

8.  Metabolism of phosphatidylglycerol, lysylphosphatidylglycerol, and cardiolipin of Staphylococcus aureus.

Authors:  S A Short; D C White
Journal:  J Bacteriol       Date:  1971-10       Impact factor: 3.490

9.  Functional interrelationships between cell membrane and cell wall in antimicrobial peptide-mediated killing of Staphylococcus aureus.

Authors:  Yan Q Xiong; Kasturi Mukhopadhyay; Michael R Yeaman; Jill Adler-Moore; Arnold S Bayer
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

10.  Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine.

Authors:  A Peschel; R W Jack; M Otto; L V Collins; P Staubitz; G Nicholson; H Kalbacher; W F Nieuwenhuizen; G Jung; A Tarkowski; K P van Kessel; J A van Strijp
Journal:  J Exp Med       Date:  2001-05-07       Impact factor: 14.307
View more
  39 in total

1.  A liaR deletion restores susceptibility to daptomycin and antimicrobial peptides in multidrug-resistant Enterococcus faecalis.

Authors:  Jinnethe Reyes; Diana Panesso; Truc T Tran; Nagendra N Mishra; Melissa R Cruz; Jose M Munita; Kavindra V Singh; Michael R Yeaman; Barbara E Murray; Yousif Shamoo; Danielle Garsin; Arnold S Bayer; Cesar A Arias
Journal:  J Infect Dis       Date:  2014-10-31       Impact factor: 5.226

2.  Unsaturation Elements and Other Modifications of Phospholipids in Bacteria: New Insight from Ultraviolet Photodissociation Mass Spectrometry.

Authors:  Molly S Blevins; Virginia K James; Carmen M Herrera; Alexandria B Purcell; M Stephen Trent; Jennifer S Brodbelt
Journal:  Anal Chem       Date:  2020-06-16       Impact factor: 6.986

3.  In vitro cross-resistance to daptomycin and host defense cationic antimicrobial peptides in clinical methicillin-resistant Staphylococcus aureus isolates.

Authors:  Nagendra N Mishra; James McKinnell; Michael R Yeaman; Aileen Rubio; Cynthia C Nast; Liang Chen; Barry N Kreiswirth; Arnold S Bayer
Journal:  Antimicrob Agents Chemother       Date:  2011-06-27       Impact factor: 5.191

4.  Reduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis.

Authors:  Anna-Barbara Hachmann; Elif Sevim; Ahmed Gaballa; David L Popham; Haike Antelmann; John D Helmann
Journal:  Antimicrob Agents Chemother       Date:  2011-06-27       Impact factor: 5.191

5.  The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides.

Authors:  Soo-Jin Yang; Arnold S Bayer; Nagendra N Mishra; Michael Meehl; Nagender Ledala; Michael R Yeaman; Yan Q Xiong; Ambrose L Cheung
Journal:  Infect Immun       Date:  2011-10-10       Impact factor: 3.441

6.  Reversible daptomycin tolerance of adherent staphylococci in an implant infection model.

Authors:  Anne-K John; Mathias Schmaler; Nina Khanna; Regine Landmann
Journal:  Antimicrob Agents Chemother       Date:  2011-05-16       Impact factor: 5.191

Review 7.  Mechanism of Action and Resistance to Daptomycin in Staphylococcus aureus and Enterococci.

Authors:  William R Miller; Arnold S Bayer; Cesar A Arias
Journal:  Cold Spring Harb Perspect Med       Date:  2016-11-01       Impact factor: 6.915

Review 8.  A current perspective on daptomycin for the clinical microbiologist.

Authors:  Romney M Humphries; Simon Pollett; George Sakoulas
Journal:  Clin Microbiol Rev       Date:  2013-10       Impact factor: 26.132

9.  Correlation of cell membrane lipid profiles with daptomycin resistance in methicillin-resistant Staphylococcus aureus.

Authors:  Nagendra N Mishra; Arnold S Bayer
Journal:  Antimicrob Agents Chemother       Date:  2012-12-17       Impact factor: 5.191

10.  Evaluation of the novel combination of high-dose daptomycin plus trimethoprim-sulfamethoxazole against daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus using an in vitro pharmacokinetic/pharmacodynamic model of simulated endocardial vegetations.

Authors:  Molly E Steed; Brian J Werth; Cortney E Ireland; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2012-08-20       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.