Literature DB >> 27207430

Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance.

Karin M Hoffmeister1, Hervé Falet2.   

Abstract

The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review will focus on the mechanisms of platelet senescence with specific emphasis on the role of post-translational modifications in platelet life-span and thrombopoietin production downstream of the hepatic Ashwell-Morrell receptor.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Ashwell Morell Receptor; JAK2; STAT3; glycans; platelet clearance; thrombopoietin

Mesh:

Substances:

Year:  2016        PMID: 27207430      PMCID: PMC5399515          DOI: 10.1016/S0049-3848(16)30370-X

Source DB:  PubMed          Journal:  Thromb Res        ISSN: 0049-3848            Impact factor:   3.944


  62 in total

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