Tekin Guney1, İlyas Ferit Kanat2, Afra Alkan3, Murat Alisik4, Sema Akinci5, Kamile Silay6, Salim Neselioglu7, Imdat Dilek8, Ozcan Erel7. 1. a Department of Hematology , Turkiye Yuksek Ihtisas Training and Research Hospital , Ankara , Turkey. 2. b Department of Internal Medicine , Ataturk Training and Research Hospital , Ankara , Turkey. 3. c Department of Biostatistics and Medical Informatics , Ankara Yildirim Beyazit University. 4. d Department of Medical Biochemistry , Ataturk Training and Research Hospital , Ankara , Turkey. 5. e Department of Hematology , Ataturk Training and Research Hospital , Ankara , Turkey. 6. f Department of Geriatrics , Yildirim Beyazıt University , Ankara , Turkey. 7. g Department of Medical Biochemistry , Yildirim Beyazıt University , Ankara , Turkey. 8. h Department of Hematology , Yildirim Beyazıt University , Ankara , Turkey.
Abstract
OBJECTIVES: The etiology of multiple myeloma (MM) is not exactly known. This study investigated the role of thiol/disulfide homeostasis in the etiopathogenesis of MM. METHODS: Some 50 patients with MM (aged 39-84 years) and 50 sex-matched healthy volunteer controls (aged 50-91 years) participated in this study. Venous blood samples were collected, and levels of native thiols, total thiols, and disulfide were measured. RESULTS: Native and total thiol levels in the control group were determined to be higher than in the study and patient groups (P<0.001). Disulfide levels were found to be higher in the control group than in the study group and higher in newly diagnosed patients than in outpatients who were undergoing treatment (P=0.002). The ratios of thiol levels were found to be similar in both the study and control groups (P>0.05). DISCUSSION: The results of the study show that although there was a decrease in the levels of disulfide, native thiol, and total thiol, the balance of thiol/disulfide was maintained. This is the first study to research the homeostasis of dynamic thiol/disulfide from the perspective of the new method that was used. We hope that this study will encourage and facilitate further studies in this area.
OBJECTIVES: The etiology of multiple myeloma (MM) is not exactly known. This study investigated the role of thiol/disulfide homeostasis in the etiopathogenesis of MM. METHODS: Some 50 patients with MM (aged 39-84 years) and 50 sex-matched healthy volunteer controls (aged 50-91 years) participated in this study. Venous blood samples were collected, and levels of native thiols, total thiols, and disulfide were measured. RESULTS: Native and total thiol levels in the control group were determined to be higher than in the study and patient groups (P<0.001). Disulfide levels were found to be higher in the control group than in the study group and higher in newly diagnosed patients than in outpatients who were undergoing treatment (P=0.002). The ratios of thiol levels were found to be similar in both the study and control groups (P>0.05). DISCUSSION: The results of the study show that although there was a decrease in the levels of disulfide, native thiol, and total thiol, the balance of thiol/disulfide was maintained. This is the first study to research the homeostasis of dynamic thiol/disulfide from the perspective of the new method that was used. We hope that this study will encourage and facilitate further studies in this area.
Authors: M Leimkühler; A R Bourgonje; H van Goor; M J E Campmans-Kuijpers; G H de Bock; B L van Leeuwen Journal: Ann Surg Oncol Date: 2022-02-17 Impact factor: 4.339
Authors: Mehmet G Sönmez; Betül Kozanhan; Çigˇdem D Deniz; Yunus E Gögˇer; Muzaffer T Kilinç; Salim Neşeliogˇlu; Özcan Ere Journal: Cent Eur J Immunol Date: 2018-06-30 Impact factor: 2.085