Richard L Weinberg1,2, Rachelle Morgenstern3, Albert DeLuca3, Jennifer Chen3, Sabahat Bokhari3. 1. Nuclear Cardiology Laboratory, Columbia University College of Physicians and Surgeons, 622 W 168th Street, PH 10-203, New York, NY, 10032, USA. rlweinbe@med.umich.edu. 2. Division of Cardiovascular Medicine, University of Michigan Health System, Cardiovascular Center Room 2713, 1500 E Medical Center Dr SPC 5853, Ann Arbor, MI, 48109-5853, USA. rlweinbe@med.umich.edu. 3. Nuclear Cardiology Laboratory, Columbia University College of Physicians and Surgeons, 622 W 168th Street, PH 10-203, New York, NY, 10032, USA.
Abstract
BACKGROUND: Sarcoidosis is an inflammatory disorder of unknown etiology that can involve the heart. While effective in imaging cardiac sarcoidosis, F-18 fluorodeoxyglucose (FDG) PET/CT often shows non-specific myocardial uptake. F-18 sodium fluoride (NaF) has been used to image inflammation in coronary artery plaques and has low background myocardial uptake. Here, we evaluated whether F-18 NaF can image myocardial inflammation due to clinically suspected cardiac sarcoidosis. PATIENTS AND METHODS: We performed a single institution pilot study testing if F-18 NaF PET/CT can detect myocardial inflammation in patients with suspected cardiac sarcoidosis. Patients underwent cardiac PET/CT with F-18 FDG as part of their routine care and subsequently received an F-18 NaF PET/CT scan. RESULTS: Three patients underwent F-18 FDG and F-18 NaF imaging. In all patients, there was F-18 FDG uptake consistent with cardiac sarcoidosis. The F-18 NaF PET/CT scans showed no myocardial uptake. CONCLUSIONS: In this small preliminary study, PET/CT scan using F-18 NaF does not appear to detect myocardial inflammation caused by suspected cardiac sarcoidosis.
BACKGROUND:Sarcoidosis is an inflammatory disorder of unknown etiology that can involve the heart. While effective in imaging cardiac sarcoidosis, F-18 fluorodeoxyglucose (FDG) PET/CT often shows non-specific myocardial uptake. F-18sodium fluoride (NaF) has been used to image inflammation in coronary artery plaques and has low background myocardial uptake. Here, we evaluated whether F-18NaF can image myocardial inflammation due to clinically suspected cardiac sarcoidosis. PATIENTS AND METHODS: We performed a single institution pilot study testing if F-18NaF PET/CT can detect myocardial inflammation in patients with suspected cardiac sarcoidosis. Patients underwent cardiac PET/CT with F-18FDG as part of their routine care and subsequently received an F-18NaF PET/CT scan. RESULTS: Three patients underwent F-18FDG and F-18NaF imaging. In all patients, there was F-18FDG uptake consistent with cardiac sarcoidosis. The F-18NaF PET/CT scans showed no myocardial uptake. CONCLUSIONS: In this small preliminary study, PET/CT scan using F-18NaF does not appear to detect myocardial inflammation caused by suspected cardiac sarcoidosis.
Authors: Marc R Dweck; Marcus W L Chow; Nikhil V Joshi; Michelle C Williams; Charlotte Jones; Alison M Fletcher; Hamish Richardson; Audrey White; Graham McKillop; Edwin J R van Beek; Nicholas A Boon; James H F Rudd; David E Newby Journal: J Am Coll Cardiol Date: 2012-04-24 Impact factor: 24.094
Authors: Nikhil V Joshi; Alex T Vesey; Michelle C Williams; Anoop S V Shah; Patrick A Calvert; Felicity H M Craighead; Su Ern Yeoh; William Wallace; Donald Salter; Alison M Fletcher; Edwin J R van Beek; Andrew D Flapan; Neal G Uren; Miles W H Behan; Nicholas L M Cruden; Nicholas L Mills; Keith A A Fox; James H F Rudd; Marc R Dweck; David E Newby Journal: Lancet Date: 2013-11-11 Impact factor: 79.321