Literature DB >> 27197248

Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences.

Lawrence A Loeb1.   

Abstract

The mutator phenotype hypothesis was postulated more than 40 years ago. It was based on the multiple enzymatic steps required to precisely replicate the 6 billion bases in the human genome each time a normal cell divides. A reduction in this accuracy during tumor progression could be responsible for the striking heterogeneity of malignant cells within a tumor and for the rapidity by which cancers become resistant to therapy. Cancer Res; 76(8); 2057-9. ©2016 AACRSee related article by Loeb et al. Cancer Res. 1974;34:2311-21. ©2016 American Association for Cancer Research.

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Year:  2016        PMID： 27197248      PMCID： PMC5004728          DOI： 10.1158/0008-5472.CAN-16-0794

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  19 in total

Review 1.  Quality control by DNA repair.

Authors:  T Lindahl; R D Wood
Journal:  Science       Date:  1999-12-03       Impact factor: 47.728

2.  Random mutations, selected mutations: A PIN opens the door to new genetic landscapes.

Authors:  Christoph A Klein
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-20       Impact factor: 11.205

3.  Defective repair replication of DNA in xeroderma pigmentosum.

Authors:  J E Cleaver
Journal:  Nature       Date:  1968-05-18       Impact factor: 49.962

4.  DNA replication error-induced extinction of diploid yeast.

Authors:  Alan J Herr; Scott R Kennedy; Gary M Knowels; Eric M Schultz; Bradley D Preston
Journal:  Genetics       Date:  2014-01-03       Impact factor: 4.562

5.  Impact of genetic dynamics and single-cell heterogeneity on development of nonstandard personalized medicine strategies for cancer.

Authors:  Robert A Beckman; Gunter S Schemmann; Chen-Hsiang Yeang
Journal:  Proc Natl Acad Sci U S A       Date:  2012-08-13       Impact factor: 11.205

6.  Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions.

Authors:  Cristian Tomasetti; Bert Vogelstein
Journal:  Science       Date:  2015-01-02       Impact factor: 47.728

7.  Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Authors:  Adam Shlien; Brittany B Campbell; Richard de Borja; Ludmil B Alexandrov; Daniele Merico; David Wedge; Peter Van Loo; Patrick S Tarpey; Paul Coupland; Sam Behjati; Aaron Pollett; Tatiana Lipman; Abolfazl Heidari; Shriya Deshmukh; Na'ama Avitzur; Bettina Meier; Moritz Gerstung; Ye Hong; Diana M Merino; Manasa Ramakrishna; Marc Remke; Roland Arnold; Gagan B Panigrahi; Neha P Thakkar; Karl P Hodel; Erin E Henninger; A Yasemin Göksenin; Doua Bakry; George S Charames; Harriet Druker; Jordan Lerner-Ellis; Matthew Mistry; Rina Dvir; Ronald Grant; Ronit Elhasid; Roula Farah; Glenn P Taylor; Paul C Nathan; Sarah Alexander; Shay Ben-Shachar; Simon C Ling; Steven Gallinger; Shlomi Constantini; Peter Dirks; Annie Huang; Stephen W Scherer; Richard G Grundy; Carol Durno; Melyssa Aronson; Anton Gartner; M Stephen Meyn; Michael D Taylor; Zachary F Pursell; Christopher E Pearson; David Malkin; P Andrew Futreal; Michael R Stratton; Eric Bouffet; Cynthia Hawkins; Peter J Campbell; Uri Tabori
Journal:  Nat Genet       Date:  2015-02-02       Impact factor: 38.330

Review 8.  Mismatch repair: mechanisms and relationship to cancer susceptibility.

Authors:  R D Kolodner
Journal:  Trends Biochem Sci       Date:  1995-10       Impact factor: 13.807

Review 9.  A panoply of errors: polymerase proofreading domain mutations in cancer.

Authors:  Emily Rayner; Inge C van Gool; Claire Palles; Stephen E Kearsey; Tjalling Bosse; Ian Tomlinson; David N Church
Journal:  Nat Rev Cancer       Date:  2016-02       Impact factor: 60.716

10.  Comprehensive molecular characterization of human colon and rectal cancer.

Authors: 
Journal:  Nature       Date:  2012-07-18       Impact factor: 49.962
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  32 in total

1.  DNA polymerase η mutational signatures are found in a variety of different types of cancer.

Authors:  Igor B Rogozin; Alexander Goncearenco; Artem G Lada; Subhajyoti De; Vyacheslav Yurchenko; German Nudelman; Anna R Panchenko; David N Cooper; Youri I Pavlov
Journal:  Cell Cycle       Date:  2018-02-15       Impact factor: 4.534

Review 2.  A population genetics perspective on the determinants of intra-tumor heterogeneity.

Authors:  Zheng Hu; Ruping Sun; Christina Curtis
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2017-03-06       Impact factor: 10.680

Review 3.  Evolutionary dynamics and significance of multiple subclonal mutations in cancer.

Authors:  Robert A Beckman; Lawrence A Loeb
Journal:  DNA Repair (Amst)       Date:  2017-06-09

Review 4.  Inferring evolutionary dynamics of mutation rates through the lens of mutation spectrum variation.

Authors:  Jedidiah Carlson; William S DeWitt; Kelley Harris
Journal:  Curr Opin Genet Dev       Date:  2020-06-30       Impact factor: 5.578

5.  Presence of allele frequency heterogeneity defined by ctDNA profiling predicts unfavorable overall survival of NSCLC.

Authors:  Zhichao Liu; Zhanhong Xie; Shen Zhao; Dawei Ye; Xiuyu Cai; Bo Cheng; Caichen Li; Shan Xiong; Jianfu Li; Hengrui Liang; Zisheng Chen; Peng Liang; Jun Liu; Jianxing He; Wenhua Liang
Journal:  Transl Lung Cancer Res       Date:  2019-12

Review 6.  Systemic and rapid restructuring of the genome: a new perspective on punctuated equilibrium.

Authors:  Lydia R Heasley; Nadia M V Sampaio; Juan Lucas Argueso
Journal:  Curr Genet       Date:  2020-11-07       Impact factor: 3.886

7.  Spontaneous cell fusions as a mechanism of parasexual recombination in tumour cell populations.

Authors:  Daria Miroshnychenko; Etienne Baratchart; David Basanta; Andriy Marusyk; Meghan C Ferrall-Fairbanks; Robert Vander Velde; Mark A Laurie; Marilyn M Bui; Aik Choon Tan; Philipp M Altrock
Journal:  Nat Ecol Evol       Date:  2021-01-18       Impact factor: 19.100

Review 8.  Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity.

Authors:  Tony M Mertz; Victoria Harcy; Steven A Roberts
Journal:  Genes (Basel)       Date:  2017-01-22       Impact factor: 4.096

Review 9.  Rising incidence of early-onset colorectal cancer - a call to action.

Authors:  Naohiko Akimoto; Tomotaka Ugai; Rong Zhong; Tsuyoshi Hamada; Kenji Fujiyoshi; Marios Giannakis; Kana Wu; Yin Cao; Kimmie Ng; Shuji Ogino
Journal:  Nat Rev Clin Oncol       Date:  2020-11-20       Impact factor: 66.675

10.  Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells.

Authors:  Maxwell A Tracy; Mitchell B Lee; Brady L Hearn; Ian T Dowsett; Luke C Thurber; Jason Loo; Anisha M Loeb; Kent Preston; Miles I Tuncel; Niloufar Ghodsian; Anna Bode; Thao T Tang; Andy R Chia; Alan J Herr
Journal:  Genetics       Date:  2020-06-08       Impact factor: 4.562
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