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Literature DB >> 271958

Regulation of proline oxidase activity by lactate.

E M Kowaloff, J M Phang, A S Granger, S J Downing.

Abstract

We found that proline oxidase, the first enzyme of the proline degradative pathway, is inhibited by lactate. The Km of the enzyme for proline increases with increasing concentrations of lactate. Since proline can be a source for gluconeogenesis, regulation of proline degradation by lactate may serve as a mechanism for allocation of metabolic fuel sources. The marked inhibition of proline oxidase at levels of lactate that commonly occur in both genetic and acquired lactic acidosis may cause the previously unexplained hyperprolinemia seen in these metabolic disorders.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1977 PMID： 271958 PMCID： PMC431723 DOI： 10.1073/pnas.74.12.5368

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

16 in total

1. Alanine and glutamine synthesis and release from skeletal muscle. IV. beta-Adrenergic inhibition of amino acid release.

Authors: A J Garber; I E Karl; D M Kipnis
Journal: J Biol Chem Date: 1976-02-10 Impact factor: 5.157

2. A radioisotopic assay for proline oxidase activity.

Authors: J M Phang; S J Downing; D L Valle; E M Kowaloff
Journal: J Lab Clin Med Date: 1975-02

3. Glucocorticoid control of hepatic proline oxidase.

Authors: E M Kowaloff; A S Granger; J M Phang
Journal: Metabolism Date: 1977-08 Impact factor: 8.694

Review 4. The glucose-alanine cycle.

Authors: P Felig
Journal: Metabolism Date: 1973-02 Impact factor: 8.694

Review 5. Gluconeogenesis.

Authors: J H Exton
Journal: Metabolism Date: 1972-10 Impact factor: 8.694

6. Studies on the proline oxidase complex.

Authors: R Kramar
Journal: Enzymologia Date: 1967-07-31

7. Metabolic fuels during and after severe exercise in athletes and non-athletes.

Authors: R H Johnson; J L Walton; H A Krebs; D H Williamson
Journal: Lancet Date: 1969-08-30 Impact factor: 79.321

8. Lactic acidosis in three sibs due to defects in both pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes.

Authors: J C Haworth; T L Perry; J P Blass; S Hansen; N Urquhart
Journal: Pediatrics Date: 1976-10 Impact factor: 7.124

9. Stimulation of hepatic glycogen synthesis by amino acids.

Authors: J Katz; S Golden; P A Wals
Journal: Proc Natl Acad Sci U S A Date: 1976-10 Impact factor: 11.205

10. Type 2 hyperprolinemia: absence of delta1-pyrroline-5-carboxylic acid dehydrogenase activity.

Authors: D L Valle; J M Phang; S I Goodman
Journal: Science Date: 1974-09-20 Impact factor: 47.728

24 in total

1. Kinetic and Cross-Sectional Studies on the Genesis of Hypoargininemia in Severe Pediatric Plasmodium falciparum Malaria.

Authors: Matthew P Rubach; Haoyue Zhang; Salvatore M Florence; Jackson P Mukemba; Ayam R Kalingonji; Nicholas M Anstey; Tsin W Yeo; Bert K Lopansri; J Will Thompson; Esther D Mwaikambo; Sarah Young; David S Millington; J Brice Weinberg; Donald L Granger
Journal: Infect Immun Date: 2019-03-25 Impact factor: 3.441

2. Hyperprolinemia in Type 2 Glutaric Aciduria and MADD-Like Profiles.

Authors: Clément Pontoizeau; Florence Habarou; Anaïs Brassier; Alice Veauville-Merllié; Coraline Grisel; Jean-Baptiste Arnoux; Christine Vianey-Saban; Robert Barouki; Bernadette Chadefaux-Vekemans; Cécile Acquaviva; Pascale de Lonlay; Chris Ottolenghi
Journal: JIMD Rep Date: 2015-09-27

3. Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH.

Authors: Maria Suntsova; Elena V Gogvadze; Sergey Salozhin; Nurshat Gaifullin; Fedor Eroshkin; Sergey E Dmitriev; Natalia Martynova; Kirill Kulikov; Galina Malakhova; Gulnur Tukhbatova; Alexey P Bolshakov; Dmitry Ghilarov; Andrew Garazha; Alexander Aliper; Charles R Cantor; Yuri Solokhin; Sergey Roumiantsev; Pavel Balaban; Alex Zhavoronkov; Anton Buzdin
Journal: Proc Natl Acad Sci U S A Date: 2013-11-11 Impact factor: 11.205

Regulation of proline oxidase activity by lactate.

1. Alanine and glutamine synthesis and release from skeletal muscle. IV. beta-Adrenergic inhibition of amino acid release.

2. A radioisotopic assay for proline oxidase activity.

3. Glucocorticoid control of hepatic proline oxidase.

Review 4. The glucose-alanine cycle.

Review 5. Gluconeogenesis.

6. Studies on the proline oxidase complex.

7. Metabolic fuels during and after severe exercise in athletes and non-athletes.

8. Lactic acidosis in three sibs due to defects in both pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes.

9. Stimulation of hepatic glycogen synthesis by amino acids.

10. Type 2 hyperprolinemia: absence of delta1-pyrroline-5-carboxylic acid dehydrogenase activity.

1. Kinetic and Cross-Sectional Studies on the Genesis of Hypoargininemia in Severe Pediatric Plasmodium falciparum Malaria.

2. Hyperprolinemia in Type 2 Glutaric Aciduria and MADD-Like Profiles.

3. Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH.

4. Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors.

5. Structural basis for the inactivation of Thermus thermophilus proline dehydrogenase by N-propargylglycine.

6. Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress.

7. Proline oxidase functions as a mitochondrial tumor suppressor in human cancers.

8. The Proline Cycle As a Potential Cancer Therapy Target.

Review 9. Unique structural features and sequence motifs of proline utilization A (PutA).

Review 10. Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy.