Literature DB >> 27191679

Anisotropically Stiff 3D Micropillar Niche Induces Extraordinary Cell Alignment and Elongation.

Yunus Alapan1, Mousa Younesi1, Ozan Akkus1,2,3, Umut A Gurkan1,2,3,4.   

Abstract

A microfabricated pillar substrate is developed to confine, align, and elongate cells, allowing decoupled analysis of stiffness and directionality in 3D. Mesenchymal stem cells and cardiomyocytes are successfully confined in a 3D environment with precisely tunable stiffness anisotropy. It is discovered that anisotropically stiff micropillar substrates provide cellular confinement in 3D, aligning cells in the stiffer direction with extraordinary elongation.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  3D microenvironment; cell shape; microfabrication; micropillar arrays; stiffness anisotropy

Mesh：

Year:  2016        PMID： 27191679      PMCID： PMC4982772          DOI： 10.1002/adhm.201600096

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  60 in total

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5.  Taking cell-matrix adhesions to the third dimension.

Authors:  E Cukierman; R Pankov; D R Stevens; K M Yamada
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6.  Alteration of human neuroblastoma cell morphology and neurite extension with micropatterns.

Authors:  In Hong Yang; Carlos C Co; Chia-Chi Ho
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7.  Microfabrication of poly (glycerol-sebacate) for contact guidance applications.

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Journal:  Biomaterials       Date:  2005-12-28       Impact factor: 12.479

8.  Rigidity-driven growth and migration of epithelial cells on microstructured anisotropic substrates.

Authors:  Alexandre Saez; Marion Ghibaudo; Axel Buguin; Pascal Silberzan; Benoît Ladoux
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-08       Impact factor: 11.205

Review 9.  Engineering structurally organized cartilage and bone tissues.

Authors:  Blanka Sharma; Jennifer H Elisseeff
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10.  Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage.

Authors:  Evelyn K F Yim; Stella W Pang; Kam W Leong
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  9 in total

1.  Integration of Mesenchymal Stem Cells into a Novel Micropillar Confinement Assay.

Authors:  Mary T Doolin; Kimberly M Stroka
Journal:  Tissue Eng Part C Methods       Date:  2019-09-11       Impact factor: 3.056

Review 2.  Regulation of the microenvironment for cardiac tissue engineering.

Authors:  Maureen Wanjare; Ngan F Huang
Journal:  Regen Med       Date:  2017-02-17       Impact factor: 3.806

Review 3.  Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.

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Journal:  Chem Rev       Date:  2017-10-09       Impact factor: 60.622

4.  Square prism micropillars on poly(methyl methacrylate) surfaces modulate the morphology and differentiation of human dental pulp mesenchymal stem cells.

Authors:  Onur Hasturk; Menekse Ermis; Utkan Demirci; Nesrin Hasirci; Vasif Hasirci
Journal:  Colloids Surf B Biointerfaces       Date:  2019-02-21       Impact factor: 5.268

5.  Control of Cell Alignment and Morphology by Redesigning ECM-Mimetic Nanotopography on Multilayer Membranes.

Authors:  Maria P Sousa; Sofia G Caridade; João F Mano
Journal:  Adv Healthc Mater       Date:  2017-03-29       Impact factor: 9.933

6.  Square prism micropillars improve osteogenicity of poly(methyl methacrylate) surfaces.

Authors:  O Hasturk; M Ermis; U Demirci; N Hasirci; V Hasirci
Journal:  J Mater Sci Mater Med       Date:  2018-05-02       Impact factor: 3.896

7.  Hydrogel Micropost Arrays with Single Post Tunability to Study Cell Volume and Mechanotransduction.

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8.  Nonlinear Cellular Mechanical Behavior Adaptation to Substrate Mechanics Identified by Atomic Force Microscope.

Authors:  Keyvan Mollaeian; Yi Liu; Siyu Bi; Yifei Wang; Juan Ren; Meng Lu
Journal:  Int J Mol Sci       Date:  2018-11-04       Impact factor: 5.923

9.  Biomimicking Fiber Scaffold as an Effective In Vitro and In Vivo MicroRNA Screening Platform for Directing Tissue Regeneration.

Authors:  Na Zhang; Ulla Milbreta; Jiah Shin Chin; Coline Pinese; Junquan Lin; Hitomi Shirahama; Wei Jiang; Hang Liu; Ruifa Mi; Ahmet Hoke; Wutian Wu; Sing Yian Chew
Journal:  Adv Sci (Weinh)       Date:  2019-02-27       Impact factor: 16.806
  9 in total

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