Literature DB >> 27190580

Direct acting antiviral therapy is curative for chronic hepatitis C/autoimmune hepatitis overlap syndrome.

Farhad Sahebjam1, Cristina H Hajdu1, Esther Nortey1, Samuel H Sigal1.   

Abstract

Autoimmune phenomena are common in patients with chronic hepatitis C. Management of chronic hepatitis C/autoimmune hepatitis syndrome has until recently been problematic due to the adverse effects of interferon on autoimmune processes and immunosuppression on viral replication. In this report we describe 3 patients with chronic hepatitis C/autoimmune hepatitis overlap syndrome who responded rapidly to direct acting anti-viral therapy. The resolution of the autoimmune process supports a direct viral role in its pathophysiology.

Entities:  

Keywords:  Autoimmune hepatitis; Direct acting antiviral therapy; Hepatitis C; Overlap syndrome

Year:  2016        PMID： 27190580      PMCID： PMC4867421          DOI： 10.4254/wjh.v8.i14.632

Source DB:  PubMed          Journal:  World J Hepatol


  15 in total

Review 1.  Hepatitis C virus infection.

Authors:  G M Lauer; B D Walker
Journal:  N Engl J Med       Date:  2001-07-05       Impact factor: 91.245

2.  A new approach for treatment of hepatitis C in hepatitis C-autoimmune hepatitis overlap syndrome.

Authors:  Ashaur Azhar; Mumtaz A Niazi; Kashif Tufail; Ashraf H Malek; Manjula Balasubramanian; Victor Araya
Journal:  Gastroenterol Hepatol (N Y)       Date:  2010-04

3.  Histological findings in chronic hepatitis C with autoimmune features.

Authors:  A J Czaja; H A Carpenter
Journal:  Hepatology       Date:  1997-08       Impact factor: 17.425

4.  Results of steroid-based therapy for the hepatitis C-autoimmune hepatitis overlap syndrome.

Authors:  T D Schiano; H S Te; R M Thomas; H Hussain; K Bond; M Black
Journal:  Am J Gastroenterol       Date:  2001-10       Impact factor: 10.864

5.  Diagnostic value and utility of the simplified International Autoimmune Hepatitis Group (IAIHG) criteria in acute and chronic liver disease.

Authors:  Andrew D Yeoman; Rachel H Westbrook; Thawab Al-Chalabi; Ivana Carey; Nigel D Heaton; Bernard C Portmann; Michael A Heneghan
Journal:  Hepatology       Date:  2009-08       Impact factor: 17.425

6.  Persistent measles virus genome in autoimmune chronic active hepatitis.

Authors:  D A Robertson; S L Zhang; E C Guy; R Wright
Journal:  Lancet       Date:  1987-07-04       Impact factor: 79.321

7.  Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment.

Authors:  Takayuki Kogure; Yoshiyuki Ueno; Koji Fukushima; Futoshi Nagasaki; Jun Inoue; Eiji Kakazu; Yasunori Matsuda; Osamu Kido; Yu Nakagome; Osamu Kimura; Noriyuki Obara; Yuta Wakui; Takao Iwasaki; Tooru Shimosegawa
Journal:  World J Gastroenterol       Date:  2007-08-28       Impact factor: 5.742

8.  Raised levels of antibodies to human viruses at the clinical onset of autoimmune chronic active hepatitis.

Authors:  M B Kalvenes; G Haukenes; G Nysaeter; K H Kalland; H Myrmel
Journal:  J Viral Hepat       Date:  1995       Impact factor: 3.728

9.  Breaking self-tolerance toward cytochrome P4502E1 (CYP2E1) in chronic hepatitis C: possible role for molecular mimicry.

Authors:  Salvatore Sutti; Matteo Vidali; Cristina Mombello; Massimo Sartori; Magnus Ingelman-Sundberg; Emanuele Albano
Journal:  J Hepatol       Date:  2010-05-31       Impact factor: 25.083

10.  Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis.

Authors:  Satoshi Oeda; Toshihiko Mizuta; Hiroshi Isoda; Takuya Kuwashiro; Noriko Oza; Shinji Iwane; Hirokazu Takahashi; Yasunori Kawaguchi; Yuichiro Eguchi; Shuji Toda; Iwata Ozaki; Keizo Anzai; Kazuma Fujimoto
Journal:  Clin J Gastroenterol       Date:  2012-03-28
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  1 in total

1.  Direct-Acting Antiviral Treatment of Patients with Hepatitis C Resolves Serologic and Histopathologic Features of Autoimmune Hepatitis.

Authors:  Camila C Simoes; Omar A Saldarriaga; Netanya S Utay; Ashley E Stueck; Sheharyar K Merwat; Shehzad N Merwat; Thomas D Schiano; Maria Isabel Fiel; Heather L Stevenson
Journal:  Hepatol Commun       Date:  2019-06-08
  1 in total

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