Literature DB >> 17708618

Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment.

Takayuki Kogure1, Yoshiyuki Ueno, Koji Fukushima, Futoshi Nagasaki, Jun Inoue, Eiji Kakazu, Yasunori Matsuda, Osamu Kido, Yu Nakagome, Osamu Kimura, Noriyuki Obara, Yuta Wakui, Takao Iwasaki, Tooru Shimosegawa.   

Abstract

A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin, and her HCV-RNA became negative at wk 12, but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH.

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Year:  2007        PMID： 17708618      PMCID： PMC4250871          DOI： 10.3748/wjg.v13.i32.4394

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


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