BACKGROUND: Pulmonary hypertension (PH) leads to reduced health-related quality of life (HRQoL). OBJECTIVE: To investigate the prevalence and course of anxiety and depression and their association with HRQoL, disease severity and survival in PH. METHODS: 131 PH patients (91 pulmonary arterial, 30 chronic thromboembolic, 10 due to lung disease; 84 female, 47 male) had repeated assessments with the Hospital Anxiety and Depression Scale (HADS), HRQoL, six-minute walk distance and WHO functional class during a mean course of 16 ± 12 months. RESULTS: Among the 49 incident and 82 prevalent PH patients, the HADS score was positive in 53%/21% (depression), 51%/24% (anxiety) and 63%/26% (total score) (all p < 0.05). The HADS score was improved at the second assessment in incident patients. The HADS score correlated with HRQoL at all consecutive assessments and with functional class until the third assessment, but not with baseline hemodynamics, age or gender. CONCLUSION: Mood disorders remain underdiagnosed in PH. The higher prevalence of anxiety/depression in incident versus prevalent patients and the improvement over time may indicate an amelioration of mood disorders after PH diagnosis and treatment.
BACKGROUND: Pulmonary hypertension (PH) leads to reduced health-related quality of life (HRQoL). OBJECTIVE: To investigate the prevalence and course of anxiety and depression and their association with HRQoL, disease severity and survival in PH. METHODS: 131 PH patients (91 pulmonary arterial, 30 chronic thromboembolic, 10 due to lung disease; 84 female, 47 male) had repeated assessments with the Hospital Anxiety and Depression Scale (HADS), HRQoL, six-minute walk distance and WHO functional class during a mean course of 16 ± 12 months. RESULTS: Among the 49 incident and 82 prevalent PH patients, the HADS score was positive in 53%/21% (depression), 51%/24% (anxiety) and 63%/26% (total score) (all p < 0.05). The HADS score was improved at the second assessment in incident patients. The HADS score correlated with HRQoL at all consecutive assessments and with functional class until the third assessment, but not with baseline hemodynamics, age or gender. CONCLUSION:Mood disorders remain underdiagnosed in PH. The higher prevalence of anxiety/depression in incident versus prevalent patients and the improvement over time may indicate an amelioration of mood disorders after PH diagnosis and treatment.
Authors: Gordon McGregor; Julie Bruce; Stuart Ennis; James Mason; Ranjit Lall; Chen Ji; Harbinder Sandhu; Kate Seers; Prithwish Banerjee; Alastair Canaway; Katie Booth; Stephanie J C Taylor; Elizabeth Robertson; Tamar Pincus; Sally Singh; David Fitzmaurice; Sarah Bowater; Paul Clift; Martin Underwood Journal: BMC Pulm Med Date: 2020-05-19 Impact factor: 3.317
Authors: Layse Nakazato; Felipe Mendes; Ilma A Paschoal; Daniela C Oliveira; Marcos M Moreira; Mônica C Pereira Journal: Pulm Circ Date: 2021-03-29 Impact factor: 3.017
Authors: Aaron Shengting Mai; Oliver Zi Hern Lim; Yeung Jek Ho; Gwyneth Kong; Grace En Hui Lim; Cheng Han Ng; Cyrus Ho; Roger Ho; Yinghao Lim; Ivandito Kuntjoro; Edgar Tay; James Yip; Nicholas W S Chew; Ting-Ting Low Journal: Front Med (Lausanne) Date: 2022-02-17
Authors: Flora Caldarone; Philippa Gebhardt; Marius M Hoeper; Karen M Olsson; Jan Fuge; Da-Hee Park; Tanja Meltendorf; Jan C Kamp; Britta Stapel; Manuel J Richter; Henning Gall; Hossein A Ghofrani; Kai G Kahl; Ivo Heitland Journal: Front Psychiatry Date: 2022-04-14 Impact factor: 4.157
Authors: Maria Wieteska-Miłek; Sebastian Szmit; Michał Florczyk; Anna Witowicz; Marcin Kurzyna Journal: Int J Environ Res Public Health Date: 2022-07-08 Impact factor: 4.614