Literature DB >> 27186426

Paradoxical role of SOX2 in gastric cancer.

Estefania Carrasco-Garcia1, Juliana C Santos2, Idoia Garcia3, Mitsue Brianti2, Mikel García-Puga1, José Pedrazzoli2, Ander Matheu3, Marcelo L Ribeiro2.   

Abstract

Sox2 is a critical regulator of embryogenesis and necessary for cellular reprogramming. It also plays an important role in tissue homeostasis and regeneration, maintaining the population of undifferentiated adult stem cells. Like various developmental and stem cell genes, SOX2 is aberrantly expressed and amplified in several human cancers. Moreover, functional studies have shown that it regulates many biological processes including cell proliferation, apoptosis, self-renewal and invasion. While it is oncogenic in most cancers, SOX2 activity is controversial in gastric cancer, where it might behave as a tumor suppressor in some situations. In this review, we discuss its role in cancer biology, with particular attention to what is known about the involvement of SOX2 in gastric cancer biology.

Entities:  

Keywords:  H. pylori; SOX2; gastric cancer; stem cells

Year:  2016        PMID： 27186426      PMCID： PMC4859879     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  86 in total

1.  SOX2 expression levels distinguish between neural progenitor populations of the developing dorsal telencephalon.

Authors:  Scott R Hutton; Larysa H Pevny
Journal:  Dev Biol       Date:  2011-01-21       Impact factor: 3.582

2.  SOX2 in squamous cell carcinoma: amplifying a pleiotropic oncogene along carcinogenesis.

Authors:  Thomas Hussenet; Stanislas du Manoir
Journal:  Cell Cycle       Date:  2010-04-15       Impact factor: 4.534

3.  Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells.

Authors:  Kuancan Liu; Ming Jiang; Yun Lu; Hao Chen; Jun Sun; Shaoping Wu; Wei-Yao Ku; Hiroshi Nakagawa; Yoshiaki Kita; Shoji Natsugoe; Jeffrey H Peters; Anil Rustgi; Mark W Onaitis; Amy Kiernan; Xiaoxin Chen; Jianwen Que
Journal:  Cell Stem Cell       Date:  2013-03-07       Impact factor: 24.633

4.  Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells.

Authors:  Marios Giannakis; Swaine L Chen; Sherif M Karam; Lars Engstrand; Jeffrey I Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-10       Impact factor: 11.205

5.  SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity.

Authors:  Rosaria Maria Rita Gangemi; Fabrizio Griffero; Daniela Marubbi; Marzia Perera; Maria Cristina Capra; Paolo Malatesta; Gian Luigi Ravetti; Gian Luigi Zona; Antonio Daga; Giorgio Corte
Journal:  Stem Cells       Date:  2009-01       Impact factor: 6.277

6.  Sox2 is required to maintain cancer stem cells in a mouse model of high-grade oligodendroglioma.

Authors:  Rebecca Favaro; Irene Appolloni; Serena Pellegatta; Alexandra Badiola Sanga; Pierfrancesco Pagella; Eleonora Gambini; Federica Pisati; Sergio Ottolenghi; Maria Foti; Gaetano Finocchiaro; Paolo Malatesta; Silvia K Nicolis
Journal:  Cancer Res       Date:  2014-03-05       Impact factor: 12.701

7.  Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential.

Authors:  Cynthia Lilian Andoniadou; Danielle Matsushima; Seyedeh Neda Mousavy Gharavy; Massimo Signore; Albert Ian Mackintosh; Marie Schaeffer; Carles Gaston-Massuet; Patrice Mollard; Thomas Stanley Jacques; Paul Le Tissier; Mehul Tulsidas Dattani; Larysa Halyna Pevny; Juan Pedro Martinez-Barbera
Journal:  Cell Stem Cell       Date:  2013-10-03       Impact factor: 24.633

8.  A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.

Authors:  J Gubbay; J Collignon; P Koopman; B Capel; A Economou; A Münsterberg; N Vivian; P Goodfellow; R Lovell-Badge
Journal:  Nature       Date:  1990-07-19       Impact factor: 49.962

9.  SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis.

Authors:  T Otsubo; Y Akiyama; K Yanagihara; Y Yuasa
Journal:  Br J Cancer       Date:  2008-02-12       Impact factor: 7.640

10.  Multipotent cell lineages in early mouse development depend on SOX2 function.

Authors:  Ariel A Avilion; Silvia K Nicolis; Larysa H Pevny; Lidia Perez; Nigel Vivian; Robin Lovell-Badge
Journal:  Genes Dev       Date:  2003-01-01       Impact factor: 11.361
View more
  15 in total

1.  SOX2 inhibits cell proliferation and metastasis, promotes apoptotic by downregulating CCND1 and PARP in gastric cancer.

Authors:  Jianfei Luo; Ruicheng Yan; Xiaobo He; Jie He
Journal:  Am J Transl Res       Date:  2018-02-15       Impact factor: 4.060

2.  Sox2 is dispensable for primary melanoma and metastasis formation.

Authors:  S M Schaefer; C Segalada; P F Cheng; M Bonalli; V Parfejevs; M P Levesque; R Dummer; S K Nicolis; L Sommer
Journal:  Oncogene       Date:  2017-04-03       Impact factor: 9.867

3.  Increased NG2 and SOX2 expression is associated with high-grade choroid plexus tumors.

Authors:  Peng Zhao; Zichao Feng; Qichao Qi; Bin Huang; Anjing Chen; Xingang Li; Xinyu Wang; Jian Wang
Journal:  Oncol Lett       Date:  2017-06-07       Impact factor: 2.967

Review 4.  The Clinical and Molecular Characteristics of Sex-Determining Region Y-Box 2 and its Prognostic Value in Breast Cancer: A Systematic Meta-Analysis.

Authors:  Gang Zhao; Xiaozhen Wang; Limei Qu; Zhu Zhu; Jinghui Hong; Haiqin Hou; Zuonong Li; Jun Wang; Zheng Lv
Journal:  Breast Care (Basel)       Date:  2020-03-26       Impact factor: 2.860

5.  Predictive Value of Stemness Factor Sox2 in Gastric Cancer Is Associated with Tumor Location and Stage.

Authors:  Lang Yang; Jun-Feng Xu; Qian Kang; Ai-Qin Li; Peng Jin; Xin Wang; Yu-Qi He; Na Li; Tao Cheng; Jian-Qiu Sheng
Journal:  PLoS One       Date:  2017-01-03       Impact factor: 3.240

6.  Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration.

Authors:  Asfar S Azmi; Yiwei Li; Irfana Muqbil; Amro Aboukameel; William Senapedis; Erkan Baloglu; Yosef Landesman; Sharon Shacham; Michael G Kauffman; Philip A Philip; Ramzi M Mohammad
Journal:  Oncotarget       Date:  2017-07-17

7.  Extra-capsular growth of lymph node metastasis correlates with poor prognosis and high SOX9 expression in gastric cancer.

Authors:  Helena Link; Martin Angele; Miriam Schüller; Petra Ganschow; Lena Machetanz; Markus Guba; Jens Werner; Thomas Kirchner; Jens Neumann
Journal:  BMC Cancer       Date:  2018-04-27       Impact factor: 4.430

Review 8.  Functional characterization of SOX2 as an anticancer target.

Authors:  Shizhen Zhang; Xiufang Xiong; Yi Sun
Journal:  Signal Transduct Target Ther       Date:  2020-07-29

Review 9.  Targeting SOX2 as a Therapeutic Strategy in Glioblastoma.

Authors:  Laura Garros-Regulez; Idoia Garcia; Estefania Carrasco-Garcia; Aquilino Lantero; Paula Aldaz; Leire Moreno-Cugnon; Olatz Arrizabalaga; Jose Undabeitia; Sergio Torres-Bayona; Jorge Villanua; Irune Ruiz; Larraitz Egaña; Nicolas Sampron; Ander Matheu
Journal:  Front Oncol       Date:  2016-10-24       Impact factor: 6.244

Review 10.  Cancer Stem Cells-Origins and Biomarkers: Perspectives for Targeted Personalized Therapies.

Authors:  Lia Walcher; Ann-Kathrin Kistenmacher; Huizhen Suo; Reni Kitte; Sarah Dluczek; Alexander Strauß; André-René Blaudszun; Tetyana Yevsa; Stephan Fricke; Uta Kossatz-Boehlert
Journal:  Front Immunol       Date:  2020-08-07       Impact factor: 7.561
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.