E Lopez-Garcia1, P Guallar-Castillón2, E Garcia-Esquinas2, F Rodríguez-Artalejo2. 1. Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de MadridL, IdiPAZ (Instituto de Investigación Sanitaria Hospital Universitario La Paz), CIBERESP (CIBER of Epidemiology and Public Health), Spain. Electronic address: esther.lopez@uam.es. 2. Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de MadridL, IdiPAZ (Instituto de Investigación Sanitaria Hospital Universitario La Paz), CIBERESP (CIBER of Epidemiology and Public Health), Spain.
Abstract
BACKGROUND: Metabolically healthy obesity (MHO) has been associated with lower risk of diabetes than obesity with cardiometabolic abnormalities (CA). However, the effect of MHO on other health outcomes is unknown. OBJECTIVE: To examine the association of metabolic status across categories of body mass index (BMI) with health-related quality of life (HRQL). METHODS: Prospective cohort with 4397 individuals aged ≥18 years, recruited in 2008-2010 and followed-up to 2012 in Spain. Normal weight was defined as BMI <25, overweight as BMI 25-29.9, and obesity as BMI ≥30 kg/m2. Two metabolic statuses were defined: healthy (0-1 CA) and unhealthy (≥2 CA). HRQL was measured with the physical component summary (PCS) and the mental component summary (MCS) of the SF-12 questionnaire. The association of joint categories of BMI and metabolic status at baseline with HRQL at 2012 was examined using linear regression, and adjusted for the main confounders. RESULTS: Compared to healthy normal-weight subjects, the unhealthy normal-weight and the healthy overweight individuals had a similar PCS score; however, the PCS was lower (worse) among those with unhealthy overweight (-1.79; 95% confidence interval [CI]: -2.66 to -0.94), with MHO (-1.45; 95% CI: -2.67 to -0.24) and unhealthy obesity (-1.97; 95% CI: -2.88 to -1.05). Being overweight or obese was not associated with the MCS score regardless of metabolic status. CONCLUSION: Metabolically unhealthy overweight, as well as obesity regardless of metabolic status, showed a worse physical HRQL. These results suggest that both obesity and CA should be addressed to improve HRQL.
BACKGROUND: Metabolically healthy obesity (MHO) has been associated with lower risk of diabetes than obesity with cardiometabolic abnormalities (CA). However, the effect of MHO on other health outcomes is unknown. OBJECTIVE: To examine the association of metabolic status across categories of body mass index (BMI) with health-related quality of life (HRQL). METHODS: Prospective cohort with 4397 individuals aged ≥18 years, recruited in 2008-2010 and followed-up to 2012 in Spain. Normal weight was defined as BMI <25, overweight as BMI 25-29.9, and obesity as BMI ≥30 kg/m2. Two metabolic statuses were defined: healthy (0-1 CA) and unhealthy (≥2 CA). HRQL was measured with the physical component summary (PCS) and the mental component summary (MCS) of the SF-12 questionnaire. The association of joint categories of BMI and metabolic status at baseline with HRQL at 2012 was examined using linear regression, and adjusted for the main confounders. RESULTS: Compared to healthy normal-weight subjects, the unhealthy normal-weight and the healthy overweight individuals had a similar PCS score; however, the PCS was lower (worse) among those with unhealthy overweight (-1.79; 95% confidence interval [CI]: -2.66 to -0.94), with MHO (-1.45; 95% CI: -2.67 to -0.24) and unhealthy obesity (-1.97; 95% CI: -2.88 to -1.05). Being overweight or obese was not associated with the MCS score regardless of metabolic status. CONCLUSION: Metabolically unhealthy overweight, as well as obesity regardless of metabolic status, showed a worse physical HRQL. These results suggest that both obesity and CA should be addressed to improve HRQL.
Authors: Sarah S Farabi; Gordon I Smith; George G Schweitzer; Richard I Stein; Samuel Klein Journal: Int J Obes (Lond) Date: 2022-07-11 Impact factor: 5.551
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Authors: Alba Marcos-Delgado; Tania Fernández-Villa; Miguel Ángel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; Olga Castañer; J Alfredo Martínez; Ángel M Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramon Estruch; Francisco J Tinahones; José Lapetra; J LLuís Serra-Majem; Laura García-Molina; Josep A Tur; José Antonio de Paz; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Lidia Daimiel; Emilio Ros; Nancy Babio; Ignacio M Gimenez-Alba; Estefanía Toledo; María Dolores Zomeño; M A Zulet; Jessica Vaquero-Luna; Jessica Pérez-López; Ana Pastor-Morel; Aina M Galmes-Panades; Antonio García-Rios; Rosa Casas; María Rosa Bernal-López; José Manuel Santos-Lozano; Nerea Becerra-Tomás; Carolina Ortega-Azorin; Zenaida Vázquez-Ruiz; Karla Alejandra Pérez-Vega; Itziar Abete; Carolina Sorto-Sánchez; Antoni Palau-Galindo; Iñigo Galilea-Zabalza; Júlia Muñoz-Martínez; Vicente Martín Journal: Int J Environ Res Public Health Date: 2020-05-25 Impact factor: 3.390