Literature DB >> 27182436

Optimising selective excitation pulses to maximise saturation transfer difference NMR spectroscopy.

Nathan B Ley1, Michelle L Rowe1, Richard A Williamson1, Mark J Howard1.   

Abstract

A simple method is presented that optimizes the STD NMR Gaussian pulse to deliver significant increases in STD amplification factors with minimal perturbation of the ligand. This approach is practically demonstrated using the wheat-germ agglutinin/N-acetyl-D-glucosamine protein-ligand system.

Entities:  

Year:  2014        PMID： 27182436      PMCID： PMC4864509          DOI： 10.1039/C3RA46246C

Source DB:  PubMed          Journal:  RSC Adv        ISSN： 2046-2069            Impact factor:   3.361


  21 in total

Review 1.  Saturation transfer difference NMR spectroscopy for identifying ligand epitopes and binding specificities.

Authors:  B Meyer; J Klein; M Mayer; R Meinecke; H Möller; A Neffe; O Schuster; J Wülfken; Y Ding; O Knaie; J Labbe; M M Palcic; O Hindsgaul; B Wagner; B Ernst
Journal:  Ernst Schering Res Found Workshop       Date:  2004

Review 2.  Theory and applications of NMR-based screening in pharmaceutical research.

Authors:  Christopher A Lepre; Jonathan M Moore; Jeffrey W Peng
Journal:  Chem Rev       Date:  2004-08       Impact factor: 60.622

3.  NMR analysis of carbohydrate-protein interactions.

Authors:  Jesus Angulo; Christoph Rademacher; Thorsten Biet; Andrew J Benie; Astrid Blume; Hannelore Peters; Monica Palcic; Francisco Parra; Thomas Peters
Journal:  Methods Enzymol       Date:  2006       Impact factor: 1.600

Review 4.  Recent developments and applications of saturation transfer difference nuclear magnetic resonance (STD NMR) spectroscopy.

Authors:  Jane L Wagstaff; Samantha L Taylor; Mark J Howard
Journal:  Mol Biosyst       Date:  2013-04-05

5.  Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor.

Authors:  M Mayer; B Meyer
Journal:  J Am Chem Soc       Date:  2001-06-27       Impact factor: 15.419

6.  Screening mixtures for biological activity by NMR.

Authors:  B Meyer; T Weimar; T Peters
Journal:  Eur J Biochem       Date:  1997-06-15

7.  Blood group B galactosyltransferase: insights into substrate binding from NMR experiments.

Authors:  Jesus Angulo; Brigitte Langpap; Astrid Blume; Thorsten Biet; Bernd Meyer; N Rama Krishna; Hannelore Peters; Monica M Palcic; Thomas Peters
Journal:  J Am Chem Soc       Date:  2006-10-18       Impact factor: 15.419

Review 8.  Perspectives on NMR in drug discovery: a technique comes of age.

Authors:  Maurizio Pellecchia; Ivano Bertini; David Cowburn; Claudio Dalvit; Ernest Giralt; Wolfgang Jahnke; Thomas L James; Steve W Homans; Horst Kessler; Claudio Luchinat; Bernd Meyer; Hartmut Oschkinat; Jeff Peng; Harald Schwalbe; Gregg Siegal
Journal:  Nat Rev Drug Discov       Date:  2008-09       Impact factor: 84.694

9.  NMR experiments reveal the molecular basis of receptor recognition by a calicivirus.

Authors:  Christoph Rademacher; N Rama Krishna; Monica Palcic; Francisco Parra; Thomas Peters
Journal:  J Am Chem Soc       Date:  2008-02-27       Impact factor: 15.419

10.  Ligand-receptor binding affinities from saturation transfer difference (STD) NMR spectroscopy: the binding isotherm of STD initial growth rates.

Authors:  Jesús Angulo; Pedro M Enríquez-Navas; Pedro M Nieto
Journal:  Chemistry       Date:  2010-07-12       Impact factor: 5.236
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  2 in total

1.  Q2DSTD NMR deciphers epitope-mapping variability for peptide recognition of integrin αvβ6.

Authors:  Jessica L Sorge; Jane L Wagstaff; Michelle L Rowe; Richard A Williamson; Mark J Howard
Journal:  Org Biomol Chem       Date:  2015-06-29       Impact factor: 3.876

2.  Spin Saturation Transfer Difference NMR (SSTD NMR): A New Tool to Obtain Kinetic Parameters of Chemical Exchange Processes.

Authors:  María Teresa Quirós; Colin Macdonald; Jesús Angulo; María Paz Muñoz
Journal:  J Vis Exp       Date:  2016-11-12       Impact factor: 1.355
  2 in total

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