Michelle Eckerle1,2, Patrick Lahni2,3, Hector Wong2,3. 1. a Division of Emergency Medicine , Cincinnati Children's Hospital Medical Center , Cincinnati , OH , USA . 2. b Department of Pediatrics , University of Cincinnati College of Medicine , Cincinnati , OH , USA , and. 3. c Division of Critical Care Medicine , Cincinnati Children's Hospital Medical Center and Cincinnati Children's Hospital Research Foundation , Cincinnati , OH , USA.
Abstract
CONTEXT: IL-27 is a novel biomarker to identify bacterial infection in children. OBJECTIVE: IL-27 was evaluated among pediatric emergency department (ED) patients and compared with procalcitonin (PCT). METHODS AND RESULTS: Children undergoing blood, urine, or cerebrospinal fluid cultures had IL-27 and PCT assays performed. Bacterial infection was defined as a positive culture or a clinical diagnosis based on chart review. IL-27 and PCT were increased among patients with bacterial infection and demonstrated comparable AUC's (0.62 versus 0.61). A decision tree incorporating IL-27, PCT, and white blood cell count improved the AUC (0.80). CONCLUSION: IL-27 is a viable candidate biomarker to identify bacterial infection among ED patients and is comparable with PCT.
CONTEXT: IL-27 is a novel biomarker to identify bacterial infection in children. OBJECTIVE:IL-27 was evaluated among pediatric emergency department (ED) patients and compared with procalcitonin (PCT). METHODS AND RESULTS:Children undergoing blood, urine, or cerebrospinal fluid cultures had IL-27 and PCT assays performed. Bacterial infection was defined as a positive culture or a clinical diagnosis based on chart review. IL-27 and PCT were increased among patients with bacterial infection and demonstrated comparable AUC's (0.62 versus 0.61). A decision tree incorporating IL-27, PCT, and white blood cell count improved the AUC (0.80). CONCLUSION:IL-27 is a viable candidate biomarker to identify bacterial infection among ED patients and is comparable with PCT.
Authors: Halden F Scott; Aaron J Donoghue; David F Gaieski; Ronald F Marchese; Rakesh D Mistry Journal: Acad Emerg Med Date: 2012-11 Impact factor: 3.451
Authors: Andrea T Cruz; Andrew M Perry; Eric A Williams; Jeanine M Graf; Elizabeth R Wuestner; Binita Patel Journal: Pediatrics Date: 2011-02-21 Impact factor: 7.124
Authors: Hector R Wong; Natalie Z Cvijanovich; Mark Hall; Geoffrey L Allen; Neal J Thomas; Robert J Freishtat; Nick Anas; Keith Meyer; Paul A Checchia; Richard Lin; Michael T Bigham; Anita Sen; Jeffrey Nowak; Michael Quasney; Jared W Henricksen; Arun Chopra; Sharon Banschbach; Eileen Beckman; Kelli Harmon; Patrick Lahni; Thomas P Shanley Journal: Crit Care Date: 2012-10-29 Impact factor: 9.097