Literature DB >> 27178360

Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.

Kiyofumi Ninomiya1,2, Chiaki Motai1,3, Eriko Nishida1, Niichiro Kitagawa1,3, Kazuya Yoshihara1, Takao Hayakawa1, Osamu Muraoka1,2, Xuezheng Li4, Seikou Nakamura4, Masayuki Yoshikawa4, Hisashi Matsuda5, Toshio Morikawa6,7.   

Abstract

Seven oleanane-type triterpene saponin bisdesmosides, perennisaponins N-T (1-7), were newly isolated from a methanol extract of daisy, the flowers of Bellis perennis L. (Asteraceae). The structures were determined based on chemical and physicochemical data and confirmed using previously isolated related compounds as references. The isolates, including 13 previously reported perennisaponins A-M (8-20), exhibited anti-proliferative activities against human digestive tract carcinoma HSC-2, HSC-4, and MKN-45 cells. Among them, perennisaponin O (2, IC50 = 11.2, 14.3, and 6.9 μM, respectively) showed relatively strong activities. The mechanism of action of 2 against HSC-2 was found to involve apoptotic cell death.

Entities:  

Keywords:  Acylated oleanane-type triterpene saponin; Anti-proliferative activity; Apoptosis; Asteraceae; Bellis perennis; Daisy; Perennisaponin

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Substances：

Year:  2016        PMID： 27178360     DOI： 10.1007/s11418-016-0998-9

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  22 in total

1.  Bioactive saponins and glycosides. XXVIII. New triterpene saponins, foliatheasaponins I, II, III, IV, and V, from Tencha (the leaves of Camellia sinensis).

Authors:  Toshio Morikawa; Seikou Nakamura; Yasuyo Kato; Osamu Muraoka; Hisashi Matsuda; Masayuki Yoshikawa
Journal:  Chem Pharm Bull (Tokyo)       Date:  2007-02       Impact factor: 1.645

2.  Medicinal flowers. XXX. Eight new glycosides, everlastosides F-M, from the flowers of Helichrysum arenarium.

Authors:  Toshio Morikawa; Li-Bo Wang; Kiyofumi Ninomiya; Seikou Nakamura; Hisashi Matsuda; Osamu Muraoka; Li-Jun Wu; Masayuki Yoshikawa
Journal:  Chem Pharm Bull (Tokyo)       Date:  2009-08       Impact factor: 1.645

3.  Steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity.

Authors:  Liying Tang; Zhuju Wang; Hongwei Wu; Akihito Yokosuka; Yoshihiro Mimaki
Journal:  Phytochemistry       Date:  2014-08-21       Impact factor: 4.072

4.  Isolation of an oleanane-type saponin active from Bellis perennis through antitumor bioassay-guided procedures.

Authors:  Fatma Pehlivan Karakas; Didem Şöhretoğlu; Tibor Liptaj; Michal Štujber; Arzu Ucar Turker; Jozef Marák; İhsan Çalış; Funda Nuray Yalçın
Journal:  Pharm Biol       Date:  2014-03-12       Impact factor: 3.503

5.  Triterpenoid saponins from Aster bellidiastrum.

Authors:  T Schöpke; C al-Tawaha; V Wray; M Nimtz; K Hiller
Journal:  Phytochemistry       Date:  1997-05       Impact factor: 4.072

6.  Perennisosides I-VII, acylated triterpene saponins with antihyperlipidemic activities from the flowers of Bellis perennis.

Authors:  Toshio Morikawa; Xuezheng Li; Eriko Nishida; Yuki Ito; Hisashi Matsuda; Seikou Nakamura; Osamu Muraoka; Masayuki Yoshikawa
Journal:  J Nat Prod       Date:  2008-03-26       Impact factor: 4.050

7.  Medicinal flowers. XXI. Structures of perennisaponins A, B, C, D, E, and F, acylated oleanane-type triterpene oligoglycosides, from the flowers of Bellis perennis.

Authors:  Masayuki Yoshikawa; Xuezheng Li; Eriko Nishida; Seikou Nakamura; Hisashi Matsuda; Osamu Muraoka; Toshio Morikawa
Journal:  Chem Pharm Bull (Tokyo)       Date:  2008-04       Impact factor: 1.645

8.  Triterpenoid saponins from Bellis sylvestris, I. Structures of the major deacylsaponins.

Authors:  T Schöpke; K Hiller; V Wray; K D Köppel; K Yamasaki; R Kasai
Journal:  J Nat Prod       Date:  1994-09       Impact factor: 4.050

9.  Increased risk of developing digestive tract cancer in subjects carrying the PLCE1 rs2274223 A>G polymorphism: evidence from a meta-analysis.

Authors:  Xunlei Zhang; Yangmei Zhang; Dongying Gu; Chunxiang Cao; Qi Zhang; Zhi Xu; Yongling Gong; Jinfei Chen; Cuiju Tang
Journal:  PLoS One       Date:  2013-10-07       Impact factor: 3.240

10.  Dipeptidyl peptidase-IV inhibitory activity of dimeric dihydrochalcone glycosides from flowers of Helichrysum arenarium.

Authors:  Toshio Morikawa; Kiyofumi Ninomiya; Junji Akaki; Namiko Kakihara; Hiroyuki Kuramoto; Yurie Matsumoto; Takao Hayakawa; Osamu Muraoka; Li-Bo Wang; Li-Jun Wu; Seikou Nakamura; Masayuki Yoshikawa; Hisashi Matsuda
Journal:  J Nat Med       Date:  2015-04-29       Impact factor: 2.343
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  1 in total

1.  The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines.

Authors:  Niichiro Kitagawa; Toshio Morikawa; Chiaki Motai; Kiyofumi Ninomiya; Shuhei Okugawa; Ayaka Nishida; Masayuki Yoshikawa; Osamu Muraoka
Journal:  Int J Mol Sci       Date:  2016-11-26       Impact factor: 5.923
  1 in total

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