Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity.

Literature DB >> 25152452

Steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity.

Liying Tang¹, Zhuju Wang², Hongwei Wu², Akihito Yokosuka³, Yoshihiro Mimaki⁴.

Abstract

Six spirostanol glycosides (1-6) and 12 known compounds (7-18) were isolated from the underground parts of Dracaena thalioides (Agavaceae). Their structures were determined by spectroscopic analysis, including 2D NMR spectroscopic data, and chemical transformations. The isolated compounds were evaluated for cytotoxic activity against HL-60 human leukemia cells. Compounds 1, 3-6, and 8-18 showed cytotoxicity against HL-60 cells, of which 10, a bisdesmosidic spirostanol derivative, showed potent cytotoxicity against HL-60 cells with an IC50 value of 0.38μM and induced apoptosis in HL-60 cells.

Entities: Chemical Disease Gene Species

Keywords: Agavaceae; Apoptosis; Cytotoxic activity; Dracaena thalioides; HL-60 cells; Spirostanol glycosides; Steroidal glycosides

Mesh：

Substances：

Year: 2014 PMID： 25152452 DOI： 10.1016/j.phytochem.2014.07.021

Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072

Keyword Cloud
Cited

5 in total

1. Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.

Authors: Kiyofumi Ninomiya; Chiaki Motai; Eriko Nishida; Niichiro Kitagawa; Kazuya Yoshihara; Takao Hayakawa; Osamu Muraoka; Xuezheng Li; Seikou Nakamura; Masayuki Yoshikawa; Hisashi Matsuda; Toshio Morikawa
Journal: J Nat Med Date: 2016-05-13 Impact factor: 2.343

2. Structural Characterization of Cholestane Rhamnosides from Ornithogalum saundersiae Bulbs and Their Cytotoxic Activity against Cultured Tumor Cells.

Authors: Tomoki Iguchi; Minpei Kuroda; Rei Naito; Tomoyuki Watanabe; Yukiko Matsuo; Akihito Yokosuka; Yoshihiro Mimaki
Journal: Molecules Date: 2017-07-25 Impact factor: 4.411

Steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity.

1. Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.

2. Structural Characterization of Cholestane Rhamnosides from Ornithogalum saundersiae Bulbs and Their Cytotoxic Activity against Cultured Tumor Cells.

3. New Steroidal Saponins from the Rhizomes of Paris vietnamensis and Their Cytotoxicity.

4. Novel steroidal saponins with cytotoxic activities from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl.

Review 5. Structures and Bioactivities of Steroidal Saponins Isolated from the Genera Dracaena and Sansevieria.