| Literature DB >> 27175824 |
Marcin K Wasko1,2,3, Stuart B Goodman4,5.
Abstract
Aseptic loosening remains the most significant long-term complication of total hip replacement. The current paradigm points to an inflammatory response to wear particles as its main trigger. Recently, there have been increasing numbers of positive bacterial isolates reported among patients with clinically absent infection. This paper reviews existing evidence on possible involvement of bacteria and microbial-associated molecular patterns in the pathology of so-called "aseptic loosening."Entities:
Keywords: aseptic loosening; infection; microbial-associated molecular patterns; osteolysis; total hip replacement
Mesh:
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Year: 2016 PMID: 27175824 PMCID: PMC5529039 DOI: 10.1002/jor.23292
Source DB: PubMed Journal: J Orthop Res ISSN: 0736-0266 Impact factor: 3.494