Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deconvoluting MLL1-dependent pathways in hematopoiesis and leukemogenesis.

Literature DB >> 27175274

Deconvoluting MLL1-dependent pathways in hematopoiesis and leukemogenesis.

Abstract

Entities: Disease Gene

Keywords: HSC quiescence; HSC self-renewal; Mecom; Mixed Lineage Leukemia gene; Myst1; Pbx1; Prdm16; SET domain; histone H4 lysine 16 acetylation

Year: 2014 PMID： 27175274 PMCID： PMC4851277 DOI： 10.1038/leusup.2014.5

Source DB: PubMed Journal: Leuk Suppl ISSN： 2044-5210

Keyword Cloud
References

× No keyword cloud information.

12 in total

1. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.

Authors: Tatsuya Nakamura; Toshiki Mori; Shinichiro Tada; Wladyslaw Krajewski; Tanya Rozovskaia; Richard Wassell; Garrett Dubois; Alexander Mazo; Carlo M Croce; Eli Canaani
Journal: Mol Cell Date: 2002-11 Impact factor: 17.970

Review 2. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.

Authors: Ali Shilatifard
Journal: Annu Rev Biochem Date: 2012 Impact factor: 23.643

Review 3. Trithorax group proteins: switching genes on and keeping them active.

Authors: Bernd Schuettengruber; Anne-Marie Martinez; Nicola Iovino; Giacomo Cavalli
Journal: Nat Rev Mol Cell Biol Date: 2011-11-23 Impact factor: 94.444

4. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

Authors: Yali Dou; Thomas A Milne; Alan J Tackett; Edwin R Smith; Aya Fukuda; Joanna Wysocka; C David Allis; Brian T Chait; Jay L Hess; Robert G Roeder
Journal: Cell Date: 2005-06-17 Impact factor: 41.582

5. MLL targets SET domain methyltransferase activity to Hox gene promoters.

Authors: Thomas A Milne; Scott D Briggs; Hugh W Brock; Mary Ellen Martin; Denise Gibbs; C David Allis; Jay L Hess
Journal: Mol Cell Date: 2002-11 Impact factor: 17.970

6. Truncation of the Mll gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos.

Authors: P Ayton; S F Sneddon; D B Palmer; I R Rosewell; M J Owen; B Young; R Presley; V Subramanian
Journal: Genesis Date: 2001-08 Impact factor: 2.487

Deconvoluting MLL1-dependent pathways in hematopoiesis and leukemogenesis.

1. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.

Review 2. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.

Review 3. Trithorax group proteins: switching genes on and keeping them active.

4. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

5. MLL targets SET domain methyltransferase activity to Hox gene promoters.

6. Truncation of the Mll gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos.

7. Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll.

8. Altered Hox expression and segmental identity in Mll-mutant mice.

9. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors.

10. The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis.