Shamima Akter1, Ikuko Kashino1, Tetsuya Mizoue2, Keitaro Matsuo3, Hidemi Ito4, Kenji Wakai5, Chisato Nagata6, Tomio Nakayama7, Atsuko Sadakane8, Keitaro Tanaka9, Akiko Tamakoshi10, Yumi Sugawara11, Norie Sawada12, Manami Inoue13, Shoichiro Tsugane12, Shizuka Sasazuki. 1. Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo. 2. Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo mizoue@ri.ncgm.go.jp. 3. Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya. 4. Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya. 5. Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya. 6. Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu. 7. Center for Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka. 8. Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima. 9. Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga. 10. Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo. 11. Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai. 12. Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo. 13. Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo AXA Department of Health and Human Security, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Abstract
OBJECTIVE: It remains unclear whether coffee drinking is associated with colorectal cancer risk. We performed a systematic review and meta-analysis of epidemiologic studies on this issue among the Japanese population. METHODS: Original data were obtained from MEDLINE searches using PubMed or from searches of the 'Ichushi' database, complemented with manual searches. Meta-analysis was performed by using the random effects model to estimate the summary relative risk with 95% confidence interval according to the study design. The final judgment was made based on a consensus of the research group members with consideration for both epidemiological evidence and biological plausibility. RESULTS: We identified five cohort studies and nine case-control studies. Of these, one cohort study reported a strong inverse association (in women only), whereas three case-control studies reported a strong inverse association with colon or rectal cancer. In meta-analysis, high consumption of coffee was not appreciably associated with colorectal cancer risk among cohort studies, whereas it was associated with significantly lower risk of colorectal or colon cancer among case-control studies. The summary relative risk/odds ratio (95% confidence interval) for the highest versus lowest categories of coffee consumption was 0.95 (0.77-1.17) and 0.78 (0.65-0.95) for cohort and case-control studies, respectively. CONCLUSIONS: The evidence is insufficient to support that coffee drinking increases or decreases the risk of colorectal cancer among the Japanese population.
OBJECTIVE: It remains unclear whether coffee drinking is associated with colorectal cancer risk. We performed a systematic review and meta-analysis of epidemiologic studies on this issue among the Japanese population. METHODS: Original data were obtained from MEDLINE searches using PubMed or from searches of the 'Ichushi' database, complemented with manual searches. Meta-analysis was performed by using the random effects model to estimate the summary relative risk with 95% confidence interval according to the study design. The final judgment was made based on a consensus of the research group members with consideration for both epidemiological evidence and biological plausibility. RESULTS: We identified five cohort studies and nine case-control studies. Of these, one cohort study reported a strong inverse association (in women only), whereas three case-control studies reported a strong inverse association with colon or rectal cancer. In meta-analysis, high consumption of coffee was not appreciably associated with colorectal cancer risk among cohort studies, whereas it was associated with significantly lower risk of colorectal or colon cancer among case-control studies. The summary relative risk/odds ratio (95% confidence interval) for the highest versus lowest categories of coffee consumption was 0.95 (0.77-1.17) and 0.78 (0.65-0.95) for cohort and case-control studies, respectively. CONCLUSIONS: The evidence is insufficient to support that coffee drinking increases or decreases the risk of colorectal cancer among the Japanese population.
Authors: Ariane Rocha Bartolomeu; Guilherme Ribeiro Romualdo; Carmen Griñán Lisón; Zein Mersini Besharat; Juan Antonio Marchal Corrales; Maria Ángel García Chaves; Luís Fernando Barbisan Journal: Int J Mol Sci Date: 2022-06-04 Impact factor: 6.208