Literature DB >> 27170508

Toll-like receptors and chronic inflammation in rheumatic diseases: new developments.

Leo A B Joosten1,2, Shahla Abdollahi-Roodsaz3,4, Charles A Dinarello1,5, Luke O'Neill6, Mihai G Netea1,2.   

Abstract

In the past few years, new developments have been reported on the role of Toll-like receptors (TLRs) in chronic inflammation in rheumatic diseases. The inhibitory function of TLR10 has been demonstrated. Receptors that enhance the function of TLRs, and several TLR inhibitors, have been identified. In addition, the role of the microbiome and TLRs in the onset of rheumatic diseases has been reported. We review novel insights on the role of TLRs in several inflammatory joint diseases, including rheumatoid arthritis, systemic lupus erythematosus, gout and Lyme arthritis, with a focus on the signalling mechanisms mediated by the Toll-IL-1 receptor (TIR) domain, the exogenous and endogenous ligands of TLRs, and the current and future therapeutic strategies to target TLR signalling in rheumatic diseases.

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Year:  2016        PMID： 27170508     DOI： 10.1038/nrrheum.2016.61

Source DB:  PubMed          Journal:  Nat Rev Rheumatol        ISSN： 1759-4790            Impact factor:   20.543


  180 in total

Review 1.  Interleukin-1 receptor associated kinase inhibitors: potential therapeutic agents for inflammatory- and immune-related disorders.

Authors:  Malkeet Singh Bahia; Maninder Kaur; Pragati Silakari; Om Silakari
Journal:  Cell Signal       Date:  2015-02-27       Impact factor: 4.315

2.  Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease.

Authors:  Kim Midwood; Sandra Sacre; Anna M Piccinini; Julia Inglis; Annette Trebaul; Emma Chan; Stefan Drexler; Nidhi Sofat; Masahide Kashiwagi; Gertraud Orend; Fionula Brennan; Brian Foxwell
Journal:  Nat Med       Date:  2009-06-28       Impact factor: 53.440

3.  cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.

Authors:  J E Sims; C J March; D Cosman; M B Widmer; H R MacDonald; C J McMahan; C E Grubin; J M Wignall; J L Jackson; S M Call
Journal:  Science       Date:  1988-07-29       Impact factor: 47.728

4.  Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.

Authors:  Terry K Means; Eicke Latz; Fumitaka Hayashi; Mandakolathur R Murali; Douglas T Golenbock; Andrew D Luster
Journal:  J Clin Invest       Date:  2005-02       Impact factor: 14.808

5.  Expression of myeloid related proteins (MRP) 8 and 14 and the MRP8/14 heterodimer in rheumatoid arthritis synovial membrane.

Authors:  P Youssef; J Roth; M Frosch; P Costello; O Fitzgerald; C Sorg; B Bresnihan
Journal:  J Rheumatol       Date:  1999-12       Impact factor: 4.666

6.  The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses.

Authors:  David L Boone; Emre E Turer; Eric G Lee; Regina-Celeste Ahmad; Matthew T Wheeler; Colleen Tsui; Paula Hurley; Marcia Chien; Sophia Chai; Osamu Hitotsumatsu; Elizabeth McNally; Cecile Pickart; Averil Ma
Journal:  Nat Immunol       Date:  2004-08-29       Impact factor: 25.606

7.  RDP58 inhibits T cell-mediated bladder inflammation in an autoimmune cystitis model.

Authors:  Wujiang Liu; Barry R Deyoung; Xiaohong Chen; David P Evanoff; Yi Luo
Journal:  J Autoimmun       Date:  2007-12-26       Impact factor: 7.094

Review 8.  TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization.

Authors:  Cecilia Garlanda; Hans-Joachim Anders; Alberto Mantovani
Journal:  Trends Immunol       Date:  2009-08-21       Impact factor: 16.687

9.  Fecal microbiota in early rheumatoid arthritis.

Authors:  Jussi Vaahtovuo; Eveliina Munukka; Mika Korkeamäki; Reijo Luukkainen; Paavo Toivanen
Journal:  J Rheumatol       Date:  2008-06-01       Impact factor: 4.666

10.  TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice.

Authors:  Benoit Desnues; Amanda Beatriz Macedo; Annie Roussel-Queval; Johnny Bonnardel; Sandrine Henri; Olivier Demaria; Lena Alexopoulou
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-13       Impact factor: 11.205
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  62 in total

1.  TCL1A Single-Nucleotide Polymorphisms and Estrogen-Mediated Toll-Like Receptor-MYD88-Dependent Nuclear Factor-κB Activation: Single-Nucleotide Polymorphism- and Selective Estrogen Receptor Modulator-Dependent Modification of Inflammation and Immune Response.

Authors:  Ming-Fen Ho; James N Ingle; Tim Bongartz; Krishna R Kalari; Paul E Goss; Lois E Shepherd; Taisei Mushiroda; Michiaki Kubo; Liewei Wang; Richard M Weinshilboum
Journal:  Mol Pharmacol       Date:  2017-06-14       Impact factor: 4.436

Review 2.  Targeting Innate Immunity for Type 1 Diabetes Prevention.

Authors:  James C Needell; Danny Zipris
Journal:  Curr Diab Rep       Date:  2017-09-27       Impact factor: 4.810

Review 3.  Persistent RNA virus infections: do PAMPS drive chronic disease?

Authors:  Mary K McCarthy; Thomas E Morrison
Journal:  Curr Opin Virol       Date:  2017-02-17       Impact factor: 7.090

Review 4.  The Microbiome: a Revolution in Treatment for Rheumatic Diseases?

Authors:  James T Rosenbaum; Mark J Asquith
Journal:  Curr Rheumatol Rep       Date:  2016-10       Impact factor: 4.592

5.  USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis.

Authors:  Pierre-Yves Jean-Charles; Jiao-Hui Wu; Lisheng Zhang; Suneet Kaur; Igor Nepliouev; Jonathan A Stiber; Leigh Brian; Rui Qi; Virginia Wertman; Sudha K Shenoy; Neil J Freedman
Journal:  Arterioscler Thromb Vasc Biol       Date:  2018-10       Impact factor: 8.311

Review 6.  Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases.

Authors:  Zejun Zhou; Miao Ding; Lei Huang; Gary Gilkeson; Ren Lang; Wei Jiang
Journal:  Clin Immunol       Date:  2016-09-09       Impact factor: 3.969

Review 7.  Calprotectin (S100A8/S100A9): a key protein between inflammation and cancer.

Authors:  Fatemeh Shabani; Alireza Farasat; Majid Mahdavi; Nematollah Gheibi
Journal:  Inflamm Res       Date:  2018-08-06       Impact factor: 4.575

8.  Polyene Phosphatidylcholine inhibited the inflammatory response in LPS-stimulated macrophages and ameliorated the adjuvant-induced rat arthritis.

Authors:  Wei Pan; Wen-Ting Hao; Hui-Wen Xu; Su-Ping Qin; Xiang-Yang Li; Xiao-Mei Liu; Fen-Fen Sun; Hui Li; Ren-Xian Tang; Kui-Yang Zheng
Journal:  Am J Transl Res       Date:  2017-09-15       Impact factor: 4.060

9.  Effects of Tim-3 silencing on the viability of fibroblast-like synoviocytes and lipopolysaccharide-induced inflammatory reactions.

Authors:  Rui Wu; Li Long; Qiqi Chen; Xiaodan Wu; Jing Zhu; Bin Zhou; Jia Cheng
Journal:  Exp Ther Med       Date:  2017-07-19       Impact factor: 2.447

10.  Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.

Authors:  Sirish K Ippagunta; Julie A Pollock; Naina Sharma; Wenwei Lin; Taosheng Chen; Kazuki Tawaratsumida; Anthony A High; Jaeki Min; Yizhe Chen; R Kiplin Guy; Vanessa Redecke; John A Katzenellenbogen; Hans Häcker
Journal:  Sci Signal       Date:  2018-08-14       Impact factor: 8.192
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