Barbara Poletti1, Laura Carelli1, Federica Solca1, Annalisa Lafronza1, Elisa Pedroli2, Andrea Faini3, Stefano Zago4, Nicola Ticozzi1,5, Paolo Meriggi6, Pietro Cipresso2, Dorothée Lulé7, Albert C Ludolph7, Giuseppe Riva2,8, Vincenzo Silani1,5. 1. a Department of Neurology and Laboratory of Neuroscience - IRCCS Istituto Auxologico Italiano , Milan , Italy. 2. b Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano , Milan , Italy. 3. c Department of Cardiovascular, Neural and Metabolic Sciences - IRCCS Istituto Auxologico Italiano , Milan , Italy. 4. d Department of Neuroscience and Mental Health , Università degli Studi di Milano, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico , Milan , Italy. 5. e Department of Pathophysiology and Transplantation , "Dino Ferrari" Center, Università degli Studi di Milano , Milan , Italy. 6. f ICT & Biomedical Technology Integration Unit , Centre for Innovation and Technology Transfer (CITT), Fondazione Don Carlo Gnocchi Onlus , Milan , Italy. 7. g Department of Neurology - University of Ulm , Ulm , Germany , and. 8. h Department of Psychology , Catholic University of Milan , Milan , Italy.
Abstract
OBJECTIVE: To investigate the use of P300-based Brain Computer Interface (BCI) technology for the administration of motor-verbal free cognitive tests in Amyotrophic Lateral Sclerosis (ALS). METHODS: We recruited 15 ALS patients and 15 age- and education-matched healthy subjects. All participants underwent a BCI-based neuropsychological assessment, together with two standard cognitive screening tools (FAB, MoCA), two psychological questionnaires (BDI, STAI-Y) and a usability questionnaire. For patients, clinical and respiratory examinations were also performed, together with a behavioural assessment (FBI). RESULTS: Correlations were observed between standard cognitive and BCI-based neuropsychological assessment, mainly concerning execution times in the ALS group. Moreover, patients provided positive rates concerning the BCI perceived usability and subjective experience. Finally, execution times at the BCI-based neuropsychological assessment were useful to discriminate patients from controls, with patients achieving lower processing speed than controls regarding executive functions. CONCLUSIONS: The developed motor-verbal free neuropsychological battery represents an innovative approach, that could provide relevant information for clinical practice and ethical issues. Its use for cognitive evaluation throughout the course of ALS, currently not available by means of standard assessment, must be addressed in further longitudinal validation studies. Further work will be aimed at refining the developed system and enlarging the cognitive spectrum investigated.
OBJECTIVE: To investigate the use of P300-based Brain Computer Interface (BCI) technology for the administration of motor-verbal free cognitive tests in Amyotrophic Lateral Sclerosis (ALS). METHODS: We recruited 15 ALSpatients and 15 age- and education-matched healthy subjects. All participants underwent a BCI-based neuropsychological assessment, together with two standard cognitive screening tools (FAB, MoCA), two psychological questionnaires (BDI, STAI-Y) and a usability questionnaire. For patients, clinical and respiratory examinations were also performed, together with a behavioural assessment (FBI). RESULTS: Correlations were observed between standard cognitive and BCI-based neuropsychological assessment, mainly concerning execution times in the ALS group. Moreover, patients provided positive rates concerning the BCI perceived usability and subjective experience. Finally, execution times at the BCI-based neuropsychological assessment were useful to discriminate patients from controls, with patients achieving lower processing speed than controls regarding executive functions. CONCLUSIONS: The developed motor-verbal free neuropsychological battery represents an innovative approach, that could provide relevant information for clinical practice and ethical issues. Its use for cognitive evaluation throughout the course of ALS, currently not available by means of standard assessment, must be addressed in further longitudinal validation studies. Further work will be aimed at refining the developed system and enlarging the cognitive spectrum investigated.
Authors: Barbara Poletti; Laura Carelli; Federica Solca; Annalisa Lafronza; Elisa Pedroli; Andrea Faini; Nicola Ticozzi; Andrea Ciammola; Paolo Meriggi; Pietro Cipresso; Dorothée Lulé; Albert C Ludolph; Giuseppe Riva; Vincenzo Silani Journal: J Neurol Date: 2017-05-13 Impact factor: 4.849
Authors: Barbara Poletti; Laura Carelli; Federica Solca; Annalisa Lafronza; Elisa Pedroli; Andrea Faini; Stefano Zago; Nicola Ticozzi; Andrea Ciammola; Claudia Morelli; Paolo Meriggi; Pietro Cipresso; Dorothée Lulé; Albert C Ludolph; Giuseppe Riva; Vincenzo Silani Journal: Neurol Sci Date: 2017-01-11 Impact factor: 3.307
Authors: Laura Carelli; Federica Solca; Andrea Faini; Paolo Meriggi; Davide Sangalli; Pietro Cipresso; Giuseppe Riva; Nicola Ticozzi; Andrea Ciammola; Vincenzo Silani; Barbara Poletti Journal: Biomed Res Int Date: 2017-08-23 Impact factor: 3.411
Authors: Laura Carelli; Federica Solca; Andrea Faini; Fabiana Madotto; Annalisa Lafronza; Alessia Monti; Stefano Zago; Alberto Doretti; Andrea Ciammola; Nicola Ticozzi; Vincenzo Silani; Barbara Poletti Journal: Front Psychol Date: 2018-04-05
Authors: Dorothée Lulé; Katharina Hörner; Cynthia Vazquez; Helena Aho-Özhan; Jürgen Keller; Martin Gorges; Ingo Uttner; Albert C Ludolph Journal: Front Neurosci Date: 2018-08-15 Impact factor: 4.677
Authors: Jonathan Delijorge; Omar Mendoza-Montoya; Jose L Gordillo; Ricardo Caraza; Hector R Martinez; Javier M Antelis Journal: Front Neurosci Date: 2020-11-27 Impact factor: 4.677