Ander Regueiro1, Omar Abdul-Jawad Altisent1, María Del Trigo1, Francisco Campelo-Parada1, Rishi Puri1, Marina Urena1, François Philippon1, Josep Rodés-Cabau2. 1. From the Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (A.R., O.A.-J.A., M.d.T., F.C.-P., R.P., F.P., J.R.-C.); and Cardiology Department, Bichat-Claude Bernard Hospital, Paris, France (M.U.). 2. From the Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (A.R., O.A.-J.A., M.d.T., F.C.-P., R.P., F.P., J.R.-C.); and Cardiology Department, Bichat-Claude Bernard Hospital, Paris, France (M.U.). josep.rodes@criucpq.ulaval.ca.
Abstract
BACKGROUND: Available data on the clinical impact of new-onset left bundle branch block (LBBB) and permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement (TAVR) remains controversial. We aimed to evaluate the impact of (1) periprocedural new-onset LBBB or PPI post-TAVR on cardiac mortality and all-cause 1-year mortality and (2) new-onset LBBB on the need for PPI at 1-year follow-up. METHODS AND RESULTS: We performed a systematic search from PubMed and EMBASE databases for studies reporting raw data on new-onset LBBB post-TAVR and the need for PPI or mortality at 1-year follow-up, or on 1-year mortality according to the need for periprocedural PPI post-TAVR. Data from 17 studies, including 4756 patients (8 studies) and 7032 patients (11 studies) for the evaluation of the impact of new-onset LBBB and periprocedural PPI post-TAVR were sourced, respectively (with 2 studies used for both outcomes). New-onset LBBB post-TAVR was associated with a higher risk of PPI (risk ratio [RR], 2.18; 95% confidence interval [CI], 1.28-3.70) and cardiac death (RR, 1.39; 95% CI, 1.04-1.86) during follow-up, as well with a tendency toward an increase in all-cause mortality (RR, 1.21; 95% CI, 0.98-1.50). Periprocedural PPI post-TAVR was not associated with any increased risk of all-cause mortality at 1 year (RR, 1.03; 95% CI, 0.9-1.18), yet a tendency toward a protective effect on cardiac death was observed (RR, 0.78; 95% CI, 0.60-1.03). CONCLUSIONS: New-onset LBBB post-TAVR is a marker of an increased risk of cardiac death and need for PPI at 1-year follow-up. The need for PPI early post-TAVR did not increase the risk of death.
BACKGROUND: Available data on the clinical impact of new-onset left bundle branch block (LBBB) and permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement (TAVR) remains controversial. We aimed to evaluate the impact of (1) periprocedural new-onset LBBB or PPI post-TAVR on cardiac mortality and all-cause 1-year mortality and (2) new-onset LBBB on the need for PPI at 1-year follow-up. METHODS AND RESULTS: We performed a systematic search from PubMed and EMBASE databases for studies reporting raw data on new-onset LBBB post-TAVR and the need for PPI or mortality at 1-year follow-up, or on 1-year mortality according to the need for periprocedural PPI post-TAVR. Data from 17 studies, including 4756 patients (8 studies) and 7032 patients (11 studies) for the evaluation of the impact of new-onset LBBB and periprocedural PPI post-TAVR were sourced, respectively (with 2 studies used for both outcomes). New-onset LBBB post-TAVR was associated with a higher risk of PPI (risk ratio [RR], 2.18; 95% confidence interval [CI], 1.28-3.70) and cardiac death (RR, 1.39; 95% CI, 1.04-1.86) during follow-up, as well with a tendency toward an increase in all-cause mortality (RR, 1.21; 95% CI, 0.98-1.50). Periprocedural PPI post-TAVR was not associated with any increased risk of all-cause mortality at 1 year (RR, 1.03; 95% CI, 0.9-1.18), yet a tendency toward a protective effect on cardiac death was observed (RR, 0.78; 95% CI, 0.60-1.03). CONCLUSIONS: New-onset LBBB post-TAVR is a marker of an increased risk of cardiac death and need for PPI at 1-year follow-up. The need for PPI early post-TAVR did not increase the risk of death.
Authors: Mohanad Hamandi; Deborah Tabachnick; Allison T Lanfear; Ronald Baxter; Kathryn Shin; Brittany Zingler; Michael J Mack; J Michael DiMaio; Steven Kindsvater Journal: Proc (Bayl Univ Med Cent) Date: 2020-01-30
Authors: Suzanne V Arnold; Yiran Zhang; Suzanne J Baron; Thomas C McAndrew; Maria C Alu; Susheel K Kodali; Samir Kapadia; Vinod H Thourani; D Craig Miller; Michael J Mack; Martin B Leon; David J Cohen Journal: JACC Cardiovasc Interv Date: 2019-02-25 Impact factor: 11.195