| Literature DB >> 27167569 |
Jingwei Ma1,2, Yi Zhang1, Ke Tang1,2, Huafeng Zhang1, Xiaonan Yin1, Yong Li2, Pingwei Xu3, Yanling Sun2, Ruihua Ma2, Tiantian Ji2, Junwei Chen3, Shuang Zhang3, Tianzhen Zhang1, Shunqun Luo2, Yang Jin4, Xiuli Luo5, Chengyin Li5, Hongwei Gong5, Zhixiong Long6, Jinzhi Lu1, Zhuowei Hu7, Xuetao Cao1, Ning Wang3,8, Xiangliang Yang9, Bo Huang1,2.
Abstract
Developing novel approaches to reverse the drug resistance of tumor-repopulating cells (TRCs) or stem cell-like cancer cells is an urgent clinical need to improve outcomes of cancer patients. Here we show an innovative approach that reverses drug resistance of TRCs using tumor cell-derived microparticles (T-MPs) containing anti-tumor drugs. TRCs, by virtue of being more deformable than differentiated cancer cells, preferentially take up T-MPs that release anti-tumor drugs after entering cells, which in turn lead to death of TRCs. The underlying mechanisms include interfering with drug efflux and promoting nuclear entry of the drugs. Our findings demonstrate the importance of tumor cell softness in uptake of T-MPs and effectiveness of a novel approach in reversing drug resistance of TRCs with promising clinical applications.Entities:
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Year: 2016 PMID： 27167569 PMCID： PMC4897183 DOI： 10.1038/cr.2016.53
Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617