| Literature DB >> 31110292 |
Qingle Liang1, Nana Bie1, Tuying Yong1, Ke Tang2, Xiaolong Shi3,4, Zhaohan Wei1, Haibo Jia5, Xiaoqiong Zhang1, Haiyan Zhao4, Wei Huang1, Lu Gan6,7, Bo Huang8,9, Xiangliang Yang10,11.
Abstract
Extracellular microparticles (MPs) can function as drug-delivery vehicles for anticancer drugs. Here, we show that the softness of MPs derived from tumour-repopulating cells (TRCs) isolated from three-dimensional fibrin gels enhances the MPs' drug-delivery efficiency. We found that, compared with MPs derived from tumour cells cultured in conventional tissue-culture plastic, TRC-derived MPs intravenously injected in tumour-xenograft-bearing mice showed enhanced accumulation in tumour tissues, enhanced blood-vessel crossing and penetration into tumour parenchyma, and preferential uptake by highly tumorigenic TRCs. We also show that the cytoskeleton-related protein cytospin-A plays a critical role in the regulation of TRC-derived MP softness. The modulation of the mechanical properties of TRC-derived MPs could aid the efficiency of delivery of anticancer drugs.Entities:
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Year: 2019 PMID： 31110292 DOI： 10.1038/s41551-019-0405-4
Source DB: PubMed Journal: Nat Biomed Eng ISSN： 2157-846X Impact factor: 25.671