Literature DB >> 27166860

Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi.

Ying Ye1, Atsushi Minami1, Yuya Igarashi1, Miho Izumikawa2, Myco Umemura3, Nozomi Nagano4, Masayuki Machida3, Teppei Kawahara2, Kazuo Shin-Ya4, Katsuya Gomi5, Hideaki Oikawa6.   

Abstract

The biosynthetic machinery of the first fungal ribosomally synthesized and post-translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene inactivation and heterologous expression studies. The results confirmed an essential requirement for novel oxidases possessing the DUF3328 motif for macrocyclization, and highly unique side-chain modifications by three oxidases (UstCF1F2) and a pyridoxal 5'-phosphate (PLP)-dependent enzyme (UstD). These findings provide new insight into the expression of the RiPP gene clusters found in various fungi.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  RiPPs; biosynthesis; heterologous expression; natural products; ustiloxins

Mesh：

Substances：

Year:  2016        PMID： 27166860     DOI： 10.1002/anie.201602611

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  25 in total

Review 1.  Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era.

Authors:  Kenton J Hetrick; Wilfred A van der Donk
Journal:  Curr Opin Chem Biol       Date:  2017-03-02       Impact factor: 8.822

2.  Ascomycete Aspergillus oryzae Is an Efficient Expression Host for Production of Basidiomycete Terpenes by Using Genomic DNA Sequences.

Authors:  Shota Nagamine; Chengwei Liu; Jumpei Nishishita; Takuto Kozaki; Kaho Sogahata; Yoshiro Sato; Atsushi Minami; Taro Ozaki; Claudia Schmidt-Dannert; Jun-Ichi Maruyama; Hideaki Oikawa
Journal:  Appl Environ Microbiol       Date:  2019-07-18       Impact factor: 4.792

Review 3.  Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.

Authors:  Abraham J Waldman; Tai L Ng; Peng Wang; Emily P Balskus
Journal:  Chem Rev       Date:  2017-04-04       Impact factor: 60.622

Review 4.  Dehydroamino acids: chemical multi-tools for late-stage diversification.

Authors:  Jonathan W Bogart; Albert A Bowers
Journal:  Org Biomol Chem       Date:  2019-04-10       Impact factor: 3.876

5.  Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus.

Authors:  Thomas Schafhauser; Linda Jahn; Norbert Kirchner; Andreas Kulik; Liane Flor; Alexander Lang; Thibault Caradec; David P Fewer; Kaarina Sivonen; Willem J H van Berkel; Philippe Jacques; Tilmann Weber; Harald Gross; Karl-Heinz van Pée; Wolfgang Wohlleben; Jutta Ludwig-Müller
Journal:  Proc Natl Acad Sci U S A       Date:  2019-12-06       Impact factor: 11.205

6.  Discovery and Biocatalytic Application of a PLP-Dependent Amino Acid γ-Substitution Enzyme That Catalyzes C-C Bond Formation.

Authors:  Mengbin Chen; Chun-Ting Liu; Yi Tang
Journal:  J Am Chem Soc       Date:  2020-06-01       Impact factor: 15.419

Review 7.  Recent advances in the biosynthesis of RiPPs from multicore-containing precursor peptides.

Authors:  Garret M Rubin; Yousong Ding
Journal:  J Ind Microbiol Biotechnol       Date:  2020-07-02       Impact factor: 3.346

8.  Victorin, the host-selective cyclic peptide toxin from the oat pathogen Cochliobolus victoriae, is ribosomally encoded.

Authors:  Simon C Kessler; Xianghui Zhang; Megan C McDonald; Cameron L M Gilchrist; Zeran Lin; Adriana Rightmyer; Peter S Solomon; B Gillian Turgeon; Yit-Heng Chooi
Journal:  Proc Natl Acad Sci U S A       Date:  2020-09-14       Impact factor: 11.205

9.  Three Principles of Diversity-Generating Biosynthesis.

Authors:  Wenjia Gu; Eric W Schmidt
Journal:  Acc Chem Res       Date:  2017-09-11       Impact factor: 22.384

10.  Roads to Rome: Role of Multiple Cassettes in Cyanobactin RiPP Biosynthesis.

Authors:  Wenjia Gu; Debosmita Sardar; Elizabeth Pierce; Eric W Schmidt
Journal:  J Am Chem Soc       Date:  2018-11-14       Impact factor: 15.419
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