| Literature DB >> 27165743 |
Yuan Yuan1, Lingxiang Liu2, Hu Chen3, Yumeng Wang3, Yanxun Xu4, Huzhang Mao5, Jun Li1, Gordon B Mills6, Yongqian Shu7, Liang Li8, Han Liang9.
Abstract
An individual's sex has been long recognized as a key factor affecting cancer incidence, prognosis, and treatment responses. However, the molecular basis for sex disparities in cancer remains poorly understood. We performed a comprehensive analysis of molecular differences between male and female patients in 13 cancer types of The Cancer Genome Atlas and revealed two sex-effect groups associated with distinct incidence and mortality profiles. One group contains a small number of sex-affected genes, whereas the other shows much more extensive sex-biased molecular signatures. Importantly, 53% of clinically actionable genes (60/114) show sex-biased signatures. Our study provides a systematic molecular-level understanding of sex effects in diverse cancers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer types.Entities:
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Year: 2016 PMID： 27165743 PMCID： PMC4864951 DOI： 10.1016/j.ccell.2016.04.001
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743