Ondine van de Rest1, Yamin Wang2, Lisa L Barnes2, Christine Tangney2, David A Bennett2, Martha Clare Morris2. 1. From the Division of Human Nutrition (O.v.d.R.), Wageningen University, the Netherlands; and Department of Internal Medicine, Section on Nutrition and Nutritional Epidemiology (Y.W., M.C.M.), Rush Alzheimer's Disease Center (L.L.B., D.A.B.), Department of Behavioral Sciences (L.L.B.), Department of Clinical Nutrition (C.T.), and Department of Neurology (D.A.B.), Rush University Medical Center, Chicago, IL. Ondine.vandeRest@wur.nl. 2. From the Division of Human Nutrition (O.v.d.R.), Wageningen University, the Netherlands; and Department of Internal Medicine, Section on Nutrition and Nutritional Epidemiology (Y.W., M.C.M.), Rush Alzheimer's Disease Center (L.L.B., D.A.B.), Department of Behavioral Sciences (L.L.B.), Department of Clinical Nutrition (C.T.), and Department of Neurology (D.A.B.), Rush University Medical Center, Chicago, IL.
Abstract
OBJECTIVE: To examine the association between consumption of seafood and long-chain n-3 fatty acids with change in 5 cognitive domains over an average of 4.9 years. METHODS: From an ongoing longitudinal, community-based epidemiologic study of aging and dementia (the Rush Memory and Aging Project), we included 915 participants (age 81.4 ± 7.2 years, 25% men) who had completed at least one follow-up cognitive assessment and dietary data. Diet was assessed by semiquantitative food frequency questionnaire. Scores for global cognitive function and 5 cognitive domains (episodic, semantic, and working memory, perceptual speed, and visuospatial ability) were assessed using 19 cognitive tests. Mixed models adjusted for multiple risk factors of cognitive change were used to assess the associations. RESULTS: Consumption of seafood was associated with slower decline in semantic memory (β = 0.024; p = 0.03) and perceptual speed (β = 0.020; p = 0.05) in separate models adjusted for age, sex, education, participation in cognitive activities, physical activity, alcohol consumption, smoking, and total energy intake. In secondary analyses, APOE ε4 carriers demonstrated slower rates of decline in global cognition and in multiple cognitive domains with weekly seafood consumption and with moderate to high long-chain n-3 fatty acid intake from food. These associations were not present in APOE ε4 noncarriers. Higher intake levels of α-linolenic acid were associated with slower global cognitive decline, but also only in APOE ε4 carriers. CONCLUSIONS: These results suggest protective relations of one meal per week of seafood and long-chain n-3 fatty acids against decline in multiple cognitive domains. The role of APOE ε4 in this association needs further study.
OBJECTIVE: To examine the association between consumption of seafood and long-chain n-3 fatty acids with change in 5 cognitive domains over an average of 4.9 years. METHODS: From an ongoing longitudinal, community-based epidemiologic study of aging and dementia (the Rush Memory and Aging Project), we included 915 participants (age 81.4 ± 7.2 years, 25% men) who had completed at least one follow-up cognitive assessment and dietary data. Diet was assessed by semiquantitative food frequency questionnaire. Scores for global cognitive function and 5 cognitive domains (episodic, semantic, and working memory, perceptual speed, and visuospatial ability) were assessed using 19 cognitive tests. Mixed models adjusted for multiple risk factors of cognitive change were used to assess the associations. RESULTS: Consumption of seafood was associated with slower decline in semantic memory (β = 0.024; p = 0.03) and perceptual speed (β = 0.020; p = 0.05) in separate models adjusted for age, sex, education, participation in cognitive activities, physical activity, alcohol consumption, smoking, and total energy intake. In secondary analyses, APOE ε4 carriers demonstrated slower rates of decline in global cognition and in multiple cognitive domains with weekly seafood consumption and with moderate to high long-chain n-3 fatty acid intake from food. These associations were not present in APOE ε4 noncarriers. Higher intake levels of α-linolenic acid were associated with slower global cognitive decline, but also only in APOE ε4 carriers. CONCLUSIONS: These results suggest protective relations of one meal per week of seafood and long-chain n-3 fatty acids against decline in multiple cognitive domains. The role of APOE ε4 in this association needs further study.
Authors: Aron S Buchman; Patricia A Boyle; Robert S Wilson; Todd L Beck; Jeremiah F Kelly; David A Bennett Journal: Alzheimer Dis Assoc Disord Date: 2009 Jan-Mar Impact factor: 2.703
Authors: P Barberger-Gateau; C Raffaitin; L Letenneur; C Berr; C Tzourio; J F Dartigues; A Alpérovitch Journal: Neurology Date: 2007-11-13 Impact factor: 9.910
Authors: May A Beydoun; Jay S Kaufman; Philip D Sloane; Gerardo Heiss; Joseph Ibrahim Journal: Public Health Nutr Date: 2007-07-12 Impact factor: 4.022
Authors: Martha Clare Morris; John Brockman; Julie A Schneider; Yamin Wang; David A Bennett; Christy C Tangney; Ondine van de Rest Journal: JAMA Date: 2016-02-02 Impact factor: 56.272
Authors: Regina L Leckie; David E Lehman; Peter J Gianaros; Kirk I Erickson; Susan M Sereika; Dora C H Kuan; Stephen B Manuck; Christopher M Ryan; Jeffrey K Yao; Matthew F Muldoon Journal: Psychol Med Date: 2019-10-04 Impact factor: 7.723
Authors: Cécilia Samieri; Martha-Clare Morris; David A Bennett; Claudine Berr; Philippe Amouyel; Jean-François Dartigues; Christophe Tzourio; Daniel I Chasman; Francine Grodstein Journal: Am J Epidemiol Date: 2018-05-01 Impact factor: 4.897
Authors: David A Bennett; Aron S Buchman; Patricia A Boyle; Lisa L Barnes; Robert S Wilson; Julie A Schneider Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Grace Y Sun; Agnes Simonyi; Kevin L Fritsche; Dennis Y Chuang; Mark Hannink; Zezong Gu; C Michael Greenlief; Jeffrey K Yao; James C Lee; David Q Beversdorf Journal: Prostaglandins Leukot Essent Fatty Acids Date: 2017-03-10 Impact factor: 3.015