INTRODUCTION: Due to the importance that Howler monkeys have on the yellow fever (YF) epidemiological sylvatic cycle in Brazil, more accurate morphological diagnostic criteria needs to be established, especially considering the differences that may exist between the genera of Brazilian non-human primates (NHPs) involved in yellow fever virus (YFV) epizootics. METHODS: Records of YF epizootics in NHPs in Brazil between 2007 and 2009 were obtained from the Brazilian Ministry of Health database to select YF positive (n=98) Howler monkeys (Alouatta sp.) for this study. The changes described in the histopathological reports were categorized by organ and their frequencies calculated. RESULTS: The most frequent lesions observed in the animals with YF were hepatocyte apoptosis (Councilman body formation), midzonal hepatocyte necrosis, steatosis, liver hemorrhage, inflammatory mononuclear cell infiltration of the liver, renal acute tubular necrosis and interstitial nephritis. Midzonal hepatocyte necrosis, steatosis and hemorrhage presented positive correlations with apoptosis of hepatocytes, suggesting strong YFV pathogenic effect association; they were also the main histopathological changes in the Alouatta sp. A pronounced negative correlation between apoptosis of hepatocytes and hepatic mononuclear cell infiltration pointed to significant histopathological differences between YFV infection in Howler monkeys and humans. CONCLUSIONS: The results warn that NHPs may exhibit different response patterns following YFV infection and require a more careful diagnosis. Presumptive diagnosis based on primate histopathological lesions may contribute to public health service control.
INTRODUCTION: Due to the importance that Howler monkeys have on the yellow fever (YF) epidemiological sylvatic cycle in Brazil, more accurate morphological diagnostic criteria needs to be established, especially considering the differences that may exist between the genera of Brazilian non-human primates (NHPs) involved in yellow fever virus (YFV) epizootics. METHODS: Records of YF epizootics in NHPs in Brazil between 2007 and 2009 were obtained from the Brazilian Ministry of Health database to select YF positive (n=98) Howler monkeys (Alouatta sp.) for this study. The changes described in the histopathological reports were categorized by organ and their frequencies calculated. RESULTS: The most frequent lesions observed in the animals with YF were hepatocyte apoptosis (Councilman body formation), midzonal hepatocyte necrosis, steatosis, liver hemorrhage, inflammatory mononuclear cell infiltration of the liver, renal acute tubular necrosis and interstitial nephritis. Midzonal hepatocyte necrosis, steatosis and hemorrhage presented positive correlations with apoptosis of hepatocytes, suggesting strong YFV pathogenic effect association; they were also the main histopathological changes in the Alouatta sp. A pronounced negative correlation between apoptosis of hepatocytes and hepatic mononuclear cell infiltration pointed to significant histopathological differences between YFV infection in Howler monkeys and humans. CONCLUSIONS: The results warn that NHPs may exhibit different response patterns following YFV infection and require a more careful diagnosis. Presumptive diagnosis based on primate histopathological lesions may contribute to public health service control.
Authors: P O Figueiredo; A T S Silva; J S Oliveira; P E Marinho; F T Rocha; G P Domingos; P C P Poblete; L B S Oliveira; D C Duarte; C A Bonjardim; J S Abrahão; E G Kroon; B P Drumond; D B Oliveira; G S Trindade Journal: Ecohealth Date: 2018-08-16 Impact factor: 3.184
Authors: Natália C C de Azevedo Fernandes; Juliana M Guerra; Josué Díaz-Delgado; Mariana S Cunha; Leila delC Saad; Silvia D Iglezias; Rodrigo A Ressio; Cinthya Dos Santos Cirqueira; Cristina T Kanamura; Isis P Jesus; Adriana Y Maeda; Fernanda G S Vasami; Júlia de Carvalho; Leonardo J T de Araújo; Renato Pereira de Souza; Juliana S Nogueira; Roberta M F Spinola; José L Catão-Dias Journal: Emerg Infect Dis Date: 2021-01 Impact factor: 6.883
Authors: Ayisa Rodrigues Oliveira; Jana M Ritter; Daniel Oliveira Dos Santos; Fabiana Pizzolato de Lucena; Sara Aquino de Mattos; Thaynara Parente de Carvalho; Hannah Bullock; Larissa Giannini Alves Moreira; Izabela Magalhães Arthuso Vasconcelos; Fabíola Barroso Costa; Tatiane Alves da Paixão; Renato Lima Santos Journal: PLoS Negl Trop Dis Date: 2022-09-15