| Literature DB >> 27160109 |
Chengjin Zhao1, Yifen Shen2, Xuelei Tao1, Jian Xu1, Junjie Lu1, Chao Liu3, Zhiwei Xu2, Qing Tang2, Tao Tao4, Xiubing Zhang5.
Abstract
Carboxyl-terminal binding protein 1 (CtBP1), up-regulated in various types of human cancers, has been functionally associated with proliferation, anti-apoptosis, and EMT in vitro studies. However, the functional significance of CtBP1 in the pathophysiology of glioma remains unknown. In the present study, we showed the expression of CtBP1 was markedly higher in glioma tissues compared with normal brain tissues by Western blot analysis. Immunohistochemical analysis revealed that CtBP1 mainly localized in the nucleus of glioma cells. Statistical analysis suggested the upregulation of CtBP1 was considerably correlated with the WHO grade (P < 0.05) and those patients with high CtBP1 levels exhibited shorter survival time (P < 0.01). Silencing CtBP1 by short hairpin RNAi caused an inhibition of cell migration. Moreover, knockdown of CtBP1 increases E-cadherin expression and decreases vimentin expression. These data uncovered that CtBP1 protein is a valuable marker of glioma pathogenic process and that CtBP1 can serve as a novel prognostic marker for glioma therapy.Entities:
Keywords: CtBP1; E-cadherin; Glioma; Migration
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Year: 2016 PMID： 27160109 DOI： 10.1007/s10735-016-9678-z
Source DB: PubMed Journal: J Mol Histol ISSN： 1567-2379 Impact factor: 2.611